E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.039 0.15 -9999.0 0.0 -0.421 48.0 48.0 KLHL20 0.042 0.116 0.307 41.0 -0.259 14.0 55.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.001 0.118 0.319 6.0 -0.301 26.0 32.0 ENAH -0.033 0.144 -9999.0 0.0 -0.399 49.0 49.0 AP1M1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.052 -9999.0 0.0 -0.545 4.0 4.0 CDC42/GTP 0.009 0.076 -9999.0 0.0 -0.277 3.0 3.0 ABI1/Sra1/Nap1 -0.016 0.04 -9999.0 0.0 -0.178 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.096 -9999.0 0.0 -0.312 26.0 26.0 RAPGEF1 -0.032 0.143 0.3 3.0 -0.389 44.0 47.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.165 -9999.0 0.0 -0.439 51.0 51.0 CRK -0.028 0.146 0.31 2.0 -0.409 48.0 50.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.09 -9999.0 0.0 -0.344 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.311 3.0 3.0 DLG1 -0.042 0.16 -9999.0 0.0 -0.42 55.0 55.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.183 34.0 34.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.544 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.081 -9999.0 0.0 -0.235 34.0 34.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.096 -9999.0 0.0 -0.328 31.0 31.0 TIAM1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.046 0.09 -9999.0 0.0 -0.294 26.0 26.0 AKT1 -0.007 0.057 -9999.0 0.0 -0.185 2.0 2.0 PIK3R1 -0.02 0.167 -9999.0 0.0 -0.545 47.0 47.0 CDH1 0.007 0.118 -9999.0 0.0 -0.544 22.0 22.0 RhoA/GDP -0.001 0.117 0.306 7.0 -0.293 34.0 41.0 actin cytoskeleton organization 0.037 0.094 0.254 45.0 -0.186 14.0 59.0 CDC42/GDP -0.001 0.117 0.306 7.0 -0.296 30.0 37.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.067 -9999.0 0.0 -0.252 24.0 24.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.096 -9999.0 0.0 -0.312 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.291 26.0 26.0 mol:GDP -0.02 0.124 0.31 7.0 -0.336 35.0 42.0 CDC42/GTP/IQGAP1 0.043 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.121 0.314 6.0 -0.302 32.0 38.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.05 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.068 0.202 27.0 -0.227 11.0 38.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.038 0.159 -9999.0 0.0 -0.43 51.0 51.0 regulation of cell-cell adhesion -0.001 0.062 -9999.0 0.0 -0.207 24.0 24.0 WASF2 0.019 0.044 0.119 31.0 -0.119 2.0 33.0 Rap1/GTP 0.012 0.087 0.267 2.0 -0.26 24.0 26.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.093 -9999.0 0.0 -0.301 21.0 21.0 CCND1 0.017 0.08 0.231 26.0 -0.284 11.0 37.0 VAV2 -0.021 0.193 0.391 3.0 -0.515 40.0 43.0 RAP1/GDP 0.009 0.101 0.312 3.0 -0.335 5.0 8.0 adherens junction assembly -0.036 0.155 -9999.0 0.0 -0.414 52.0 52.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.089 -9999.0 0.0 -0.29 24.0 24.0 E-cadherin/beta catenin -0.006 0.089 -9999.0 0.0 -0.336 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.04 0.158 -9999.0 0.0 -0.42 54.0 54.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.013 0.146 0.283 60.0 -0.409 19.0 79.0 E-cadherin/beta catenin/alpha catenin 0.036 0.096 -9999.0 0.0 -0.34 26.0 26.0 ITGAE 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.034 0.168 -9999.0 0.0 -0.449 51.0 51.0