Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.045 0.236 0.594 2.0 -0.557 73.0 75.0 IHH 0.021 0.075 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.068 0.148 -9999.0 0.0 -0.315 126.0 126.0 LRPAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.068 0.147 0.313 126.0 -9999.0 0.0 126.0 SMO/beta Arrestin2 -0.002 0.186 0.413 2.0 -0.479 30.0 32.0 SMO -0.016 0.185 0.446 2.0 -0.5 30.0 32.0 AKT1 -0.02 0.191 -9999.0 0.0 -0.6 36.0 36.0 ARRB2 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.091 0.238 -9999.0 0.0 -0.545 111.0 111.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.183 0.444 2.0 -0.493 30.0 32.0 STIL 0.042 0.15 0.343 31.0 -0.342 7.0 38.0 DHH N/PTCH2 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.163 0.38 2.0 -0.425 26.0 28.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.111 0.392 0.671 2.0 -0.9 94.0 96.0 determination of left/right symmetry -0.015 0.183 0.444 2.0 -0.493 30.0 32.0 PIK3R1 -0.02 0.167 -9999.0 0.0 -0.545 47.0 47.0 skeletal system development -0.109 0.387 0.67 2.0 -0.888 94.0 96.0 IHH N/Hhip 0.038 0.053 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.05 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.183 0.444 2.0 -0.493 30.0 32.0 pancreas development 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.024 0.06 -9999.0 0.0 -0.545 5.0 5.0 PI3K 0.005 0.128 -9999.0 0.0 -0.369 51.0 51.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.144 0.267 -9999.0 0.0 -0.545 158.0 158.0 somite specification -0.015 0.183 0.444 2.0 -0.493 30.0 32.0 SHH Np/Cholesterol/PTCH1 -0.01 0.122 -9999.0 0.0 -0.368 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.024 0.037 -9999.0 0.0 -0.313 5.0 5.0 SHH Np/Cholesterol/Megalin -0.056 0.145 -9999.0 0.0 -0.321 110.0 110.0 SHH 0.011 0.043 -9999.0 0.0 -0.401 5.0 5.0 catabolic process -0.009 0.175 0.468 2.0 -0.362 82.0 84.0 SMO/Vitamin D3 0.01 0.172 0.409 16.0 -0.453 13.0 29.0 SHH Np/Cholesterol/Hhip 0.024 0.038 -9999.0 0.0 -0.313 5.0 5.0 LRP2 -0.119 0.255 -9999.0 0.0 -0.545 136.0 136.0 receptor-mediated endocytosis -0.061 0.196 0.35 9.0 -0.51 38.0 47.0 SHH Np/Cholesterol/BOC -0.038 0.13 -9999.0 0.0 -0.314 86.0 86.0 SHH Np/Cholesterol/CDO 0.019 0.049 -9999.0 0.0 -0.352 7.0 7.0 mesenchymal cell differentiation -0.024 0.038 0.311 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.027 0.159 0.414 17.0 -0.381 8.0 25.0 IHH N/PTCH2 0.038 0.052 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.027 0.045 -9999.0 0.0 -0.545 3.0 3.0 IHH N/PTCH1 -0.001 0.18 0.47 2.0 -0.364 82.0 84.0 Megalin/LRPAP1 -0.071 0.199 -9999.0 0.0 -0.395 139.0 139.0 PTCH2 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.034 -9999.0 0.0 -0.311 5.0 5.0 PTCH1 -0.009 0.176 0.469 2.0 -0.363 82.0 84.0 HHIP 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0