Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.191 0.304 -9999.0 0.0 -0.68 30.0 30.0 IHH -0.105 0.2 -9999.0 0.0 -0.545 23.0 23.0 SHH Np/Cholesterol/GAS1 -0.07 0.164 -9999.0 0.0 -0.34 36.0 36.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.07 0.163 0.338 36.0 -9999.0 0.0 36.0 SMO/beta Arrestin2 -0.128 0.209 -9999.0 0.0 -0.567 16.0 16.0 SMO -0.141 0.22 -9999.0 0.0 -0.553 21.0 21.0 AKT1 -0.06 0.122 -9999.0 0.0 -0.656 2.0 2.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.042 0.167 -9999.0 0.0 -0.55 14.0 14.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.139 0.217 -9999.0 0.0 -0.543 21.0 21.0 STIL -0.117 0.216 -9999.0 0.0 -0.59 17.0 17.0 DHH N/PTCH2 -0.016 0.117 -9999.0 0.0 -0.42 11.0 11.0 DHH N/PTCH1 -0.112 0.198 -9999.0 0.0 -0.564 15.0 15.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.005 0.096 -9999.0 0.0 -0.574 4.0 4.0 PTHLH -0.267 0.424 -9999.0 0.0 -1.019 29.0 29.0 determination of left/right symmetry -0.139 0.217 -9999.0 0.0 -0.543 21.0 21.0 PIK3R1 -0.019 0.131 -9999.0 0.0 -0.56 8.0 8.0 skeletal system development -0.263 0.417 -9999.0 0.0 -1.002 29.0 29.0 IHH N/Hhip -0.1 0.192 -9999.0 0.0 -0.428 34.0 34.0 DHH N/Hhip -0.044 0.155 -9999.0 0.0 -0.426 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.139 0.217 -9999.0 0.0 -0.543 21.0 21.0 pancreas development -0.057 0.173 -9999.0 0.0 -0.516 18.0 18.0 HHAT -0.001 0.092 -9999.0 0.0 -0.631 3.0 3.0 PI3K -0.005 0.097 -9999.0 0.0 -0.402 8.0 8.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.059 0.19 -9999.0 0.0 -0.561 18.0 18.0 somite specification -0.139 0.217 -9999.0 0.0 -0.543 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.13 0.227 -9999.0 0.0 -0.572 22.0 22.0 SHH Np/Cholesterol/PTCH2 -0.047 0.14 -9999.0 0.0 -0.333 27.0 27.0 SHH Np/Cholesterol/Megalin -0.07 0.157 -9999.0 0.0 -0.333 35.0 35.0 SHH -0.048 0.151 -9999.0 0.0 -0.403 22.0 22.0 catabolic process -0.123 0.21 -9999.0 0.0 -0.604 14.0 14.0 SMO/Vitamin D3 -0.143 0.229 -9999.0 0.0 -0.616 19.0 19.0 SHH Np/Cholesterol/Hhip -0.072 0.159 -9999.0 0.0 -0.344 34.0 34.0 LRP2 -0.056 0.174 -9999.0 0.0 -0.517 18.0 18.0 receptor-mediated endocytosis -0.156 0.219 -9999.0 0.0 -0.59 21.0 21.0 SHH Np/Cholesterol/BOC -0.061 0.146 -9999.0 0.0 -0.311 35.0 35.0 SHH Np/Cholesterol/CDO -0.037 0.13 -9999.0 0.0 -0.321 24.0 24.0 mesenchymal cell differentiation 0.071 0.158 0.342 34.0 -9999.0 0.0 34.0 mol:Vitamin D3 -0.129 0.229 -9999.0 0.0 -0.574 22.0 22.0 IHH N/PTCH2 -0.07 0.166 -9999.0 0.0 -0.387 27.0 27.0 CDON -0.001 0.086 -9999.0 0.0 -0.593 3.0 3.0 IHH N/PTCH1 -0.124 0.212 -9999.0 0.0 -0.611 14.0 14.0 Megalin/LRPAP1 -0.031 0.126 -9999.0 0.0 -0.366 18.0 18.0 PTCH2 -0.017 0.128 -9999.0 0.0 -0.582 7.0 7.0 SHH Np/Cholesterol -0.044 0.115 -9999.0 0.0 -0.312 22.0 22.0 PTCH1 -0.124 0.211 -9999.0 0.0 -0.607 14.0 14.0 HHIP -0.057 0.173 -9999.0 0.0 -0.517 18.0 18.0