Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.117 0.23 -9999.0 0.0 -0.569 25.0 25.0 IHH -0.042 0.107 -9999.0 0.0 -0.247 23.0 23.0 SHH Np/Cholesterol/GAS1 -0.031 0.113 -9999.0 0.0 -0.336 14.0 14.0 LRPAP1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.031 0.112 0.334 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.101 0.189 -9999.0 0.0 -0.429 22.0 22.0 SMO -0.106 0.186 -9999.0 0.0 -0.449 21.0 21.0 AKT1 -0.054 0.139 -9999.0 0.0 -0.582 6.0 6.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.008 0.108 -9999.0 0.0 -0.327 12.0 12.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.102 0.185 -9999.0 0.0 -0.442 21.0 21.0 STIL -0.07 0.148 -9999.0 0.0 -0.388 15.0 15.0 DHH N/PTCH2 0.014 0.094 -9999.0 0.0 -0.396 6.0 6.0 DHH N/PTCH1 -0.065 0.144 -9999.0 0.0 -0.337 24.0 24.0 PIK3CA 0.017 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.011 0.074 -9999.0 0.0 -0.38 4.0 4.0 PTHLH -0.186 0.365 -9999.0 0.0 -0.913 26.0 26.0 determination of left/right symmetry -0.102 0.185 -9999.0 0.0 -0.442 21.0 21.0 PIK3R1 0.007 0.091 -9999.0 0.0 -0.357 7.0 7.0 skeletal system development -0.183 0.36 -9999.0 0.0 -0.9 26.0 26.0 IHH N/Hhip -0.03 0.094 -9999.0 0.0 -0.211 22.0 22.0 DHH N/Hhip 0.004 0.087 -9999.0 0.0 -0.328 5.0 5.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.102 0.185 -9999.0 0.0 -0.442 21.0 21.0 pancreas development -0.02 0.081 -9999.0 0.0 -0.223 18.0 18.0 HHAT 0.014 0.082 -9999.0 0.0 -0.539 3.0 3.0 PI3K 0.014 0.059 -9999.0 0.0 -0.396 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.019 0.135 -9999.0 0.0 -0.352 17.0 17.0 somite specification -0.102 0.185 -9999.0 0.0 -0.442 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.079 0.147 -9999.0 0.0 -0.382 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.018 0.094 -9999.0 0.0 -0.292 12.0 12.0 SHH Np/Cholesterol/Megalin -0.021 0.09 -9999.0 0.0 -0.273 11.0 11.0 SHH -0.032 0.097 0.225 1.0 -0.398 7.0 8.0 catabolic process -0.073 0.148 -9999.0 0.0 -0.361 24.0 24.0 SMO/Vitamin D3 -0.088 0.171 -9999.0 0.0 -0.444 17.0 17.0 SHH Np/Cholesterol/Hhip -0.029 0.089 -9999.0 0.0 -0.268 12.0 12.0 LRP2 -0.011 0.08 -9999.0 0.0 -0.221 17.0 17.0 receptor-mediated endocytosis -0.094 0.165 -9999.0 0.0 -0.471 14.0 14.0 SHH Np/Cholesterol/BOC -0.027 0.098 -9999.0 0.0 -0.341 9.0 9.0 SHH Np/Cholesterol/CDO -0.016 0.089 -9999.0 0.0 -0.321 9.0 9.0 mesenchymal cell differentiation 0.028 0.089 0.266 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 -0.069 0.156 -9999.0 0.0 -0.398 16.0 16.0 IHH N/PTCH2 -0.022 0.106 -9999.0 0.0 -0.291 13.0 13.0 CDON 0.013 0.07 -9999.0 0.0 -0.433 3.0 3.0 IHH N/PTCH1 -0.056 0.157 -9999.0 0.0 -0.363 24.0 24.0 Megalin/LRPAP1 0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.005 0.1 -9999.0 0.0 -0.403 7.0 7.0 SHH Np/Cholesterol -0.014 0.077 -9999.0 0.0 -0.308 7.0 7.0 PTCH1 -0.073 0.148 -9999.0 0.0 -0.362 24.0 24.0 HHIP -0.02 0.081 -9999.0 0.0 -0.224 18.0 18.0