Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.043 -9999.0 0.0 -0.322 2.0 2.0 epithelial cell differentiation 0.047 0.036 -9999.0 0.0 -0.29 1.0 1.0 CYFIP2 0.014 0.073 -9999.0 0.0 -0.38 4.0 4.0 ENAH 0.018 0.084 0.275 3.0 -0.355 1.0 4.0 EGFR -0.01 0.139 -9999.0 0.0 -0.539 9.0 9.0 EPHA2 0.011 0.094 -9999.0 0.0 -0.539 4.0 4.0 MYO6 0.011 0.029 -9999.0 0.0 -0.28 1.0 1.0 CTNNB1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.04 0.055 -9999.0 0.0 -0.339 2.0 2.0 AQP5 -0.134 0.217 -9999.0 0.0 -0.471 40.0 40.0 CTNND1 0.023 0.048 -9999.0 0.0 -0.539 1.0 1.0 mol:PI-4-5-P2 0.011 0.028 -9999.0 0.0 -0.276 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.067 -9999.0 0.0 -0.274 6.0 6.0 EGF -0.051 0.168 -9999.0 0.0 -0.362 27.0 27.0 NCKAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.041 0.155 -9999.0 0.0 -0.481 15.0 15.0 cortical microtubule organization 0.047 0.036 -9999.0 0.0 -0.29 1.0 1.0 GO:0000145 -0.007 0.027 -9999.0 0.0 -0.264 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.038 -9999.0 0.0 -0.293 1.0 1.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.017 0.05 -9999.0 0.0 -0.48 1.0 1.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.063 -9999.0 0.0 -0.311 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.001 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.01 0.029 -9999.0 0.0 -0.28 1.0 1.0 ARF6/GTP 0.044 0.063 -9999.0 0.0 -0.291 3.0 3.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.019 0.127 -9999.0 0.0 -0.302 20.0 20.0 RhoA/GDP 0.048 0.036 -9999.0 0.0 -0.277 1.0 1.0 actin cytoskeleton organization -0.009 0.027 -9999.0 0.0 -0.274 1.0 1.0 IGF-1R heterotetramer 0.022 0.048 -9999.0 0.0 -0.538 1.0 1.0 GIT1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.022 0.048 -9999.0 0.0 -0.539 1.0 1.0 IGF1 -0.076 0.208 -9999.0 0.0 -0.454 30.0 30.0 DIAPH1 -0.028 0.181 -9999.0 0.0 -0.556 8.0 8.0 Wnt receptor signaling pathway -0.047 0.036 0.29 1.0 -9999.0 0.0 1.0 RHOA 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.017 0.05 -9999.0 0.0 -0.481 1.0 1.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.009 0.028 -9999.0 0.0 -0.28 1.0 1.0 EFNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.008 0.033 -9999.0 0.0 -0.273 2.0 2.0 Ephrin A1/EPHA2 0.031 0.07 -9999.0 0.0 -0.339 4.0 4.0 SEC6/SEC8 0.007 0.024 -9999.0 0.0 -0.263 1.0 1.0 MGAT3 -0.012 0.068 -9999.0 0.0 -0.278 6.0 6.0 HGF/MET 0.015 0.094 -9999.0 0.0 -0.297 10.0 10.0 HGF 0.001 0.108 -9999.0 0.0 -0.448 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.043 -9999.0 0.0 -0.325 2.0 2.0 actin cable formation 0.059 0.134 0.251 33.0 -0.277 1.0 34.0 KIAA1543 -0.014 0.047 -9999.0 0.0 -0.27 4.0 4.0 KIFC3 0.003 0.049 -9999.0 0.0 -0.283 4.0 4.0 NCK1 0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.011 0.028 -9999.0 0.0 -0.28 1.0 1.0 NCK1/GIT1 0.03 0.018 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.047 0.036 -9999.0 0.0 -0.29 1.0 1.0 EXOC4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.01 0.025 -9999.0 0.0 -0.28 1.0 1.0 PIP5K1C 0.011 0.029 -9999.0 0.0 -0.28 1.0 1.0 LIMA1 0.023 0.048 -9999.0 0.0 -0.539 1.0 1.0 ABI1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.035 0.105 0.317 7.0 -0.42 1.0 8.0 adherens junction assembly -0.025 0.118 0.287 1.0 -0.494 6.0 7.0 IGF-1R heterotetramer/IGF1 -0.016 0.122 -9999.0 0.0 -0.285 21.0 21.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.005 0.105 -9999.0 0.0 -0.539 5.0 5.0 PLEKHA7 0.003 0.052 -9999.0 0.0 -0.283 4.0 4.0 mol:GTP 0.038 0.062 -9999.0 0.0 -0.309 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.033 0.089 0.323 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization 0.017 0.043 -9999.0 0.0 -0.322 2.0 2.0 regulation of cell-cell adhesion -0.009 0.027 -9999.0 0.0 -0.274 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.043 -9999.0 0.0 -0.325 2.0 2.0