Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	103 (67%)	51	0.17058	1	0.018696	1	0.025025	1	0.21572	1	0.38769	1	0.60069	1	0.25766	1
PIK3CA	26 (17%)	128	0.33079	1	0.33586	1	0.0061664	0.592	0.11871	1	0.33202	1	0.51361	1	0.41633	1
BRAF	20 (13%)	134	3.2907e-07	3.36e-05	4.3712e-08	4.5e-06	9.3334e-05	0.00943	0.72185	1	0.92618	1	0.46154	1	1	1
KRAS	58 (38%)	96	0.024121	1	0.0006382	0.0638	0.055242	1	0.71991	1	0.75196	1	0.6257	1	0.28277	1
TP53	74 (48%)	80	0.0022626	0.222	0.012952	1	9.1923e-10	9.56e-08	0.27065	1	0.37976	1	0.61993	1	1	1
FBXW7	29 (19%)	125	0.22671	1	0.089159	1	0.0022274	0.221	0.0034288	0.333	0.23259	1	1	1	0.47418	1
NRAS	15 (10%)	139	0.077327	1	0.40857	1	0.92681	1	0.46546	1	0.33213	1	1	1	1	1
SMAD4	18 (12%)	136	0.30352	1	0.57961	1	0.05581	1	0.85217	1	0.49482	1	1	1	1	1
FAM123B	19 (12%)	135	0.20808	1	0.0062163	0.592	0.022835	1	0.28621	1	0.42194	1	0.42457	1	0.33826	1
SOX9	9 (6%)	145	0.23526	1	0.21364	1	0.22254	1	0.23084	1	0.46084	1	1	1	1	1
ACVR2A	8 (5%)	146	0.044979	1	0.2961	1	0.038168	1	0.19948	1	0.66829	1	1	1	0.16182	1
TNFRSF10C	6 (4%)	148	0.38104	1	0.67607	1	0.29912	1	0.67994	1	0.16933	1	1	1	1	1
ACOT4	3 (2%)	151	0.66496	1	0.39097	1	0.46194	1	NA	NA	NA	NA	1	1	1	1
SMAD2	10 (6%)	144	0.099491	1	0.19002	1	0.027665	1	1	1	0.37729	1	1	1	1	1
PCBP1	4 (3%)	150	0.32974	1	0.55218	1	0.43999	1	NA	NA	NA	NA	1	1	1	1
GGT1	3 (2%)	151	NA	NA	NA	NA	0.22952	1	NA	NA	NA	NA	1	1	1	1