Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.021 0.137 -9999.0 0.0 -0.623 9.0 9.0 IHH 0.015 0.046 -9999.0 0.0 -0.425 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.17 0.218 -9999.0 0.0 -0.426 95.0 95.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.169 0.216 0.423 95.0 -9999.0 0.0 95.0 SMO/beta Arrestin2 -0.004 0.086 -9999.0 0.0 -0.472 2.0 2.0 SMO -0.01 0.09 -9999.0 0.0 -0.501 2.0 2.0 AKT1 0.014 0.045 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.028 0.105 -9999.0 0.0 -0.301 30.0 30.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.01 0.089 -9999.0 0.0 -0.493 2.0 2.0 STIL -0.117 0.192 -9999.0 0.0 -0.344 93.0 93.0 DHH N/PTCH2 0.004 0.06 -9999.0 0.0 -0.522 1.0 1.0 DHH N/PTCH1 0.018 0.077 -9999.0 0.0 -0.422 2.0 2.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.006 0.072 -9999.0 0.0 -0.301 13.0 13.0 PTHLH 0.022 0.141 -9999.0 0.0 -0.583 9.0 9.0 determination of left/right symmetry -0.01 0.089 -9999.0 0.0 -0.493 2.0 2.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.022 0.139 -9999.0 0.0 -0.576 9.0 9.0 IHH N/Hhip -0.028 0.103 -9999.0 0.0 -0.335 5.0 5.0 DHH N/Hhip -0.033 0.098 -9999.0 0.0 -0.379 4.0 4.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.01 0.089 -9999.0 0.0 -0.493 2.0 2.0 pancreas development -0.046 0.121 -9999.0 0.0 -0.3 43.0 43.0 HHAT 0.011 0.021 -9999.0 0.0 -0.301 1.0 1.0 PI3K 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.031 0.129 -9999.0 0.0 -0.359 27.0 27.0 somite specification -0.01 0.089 -9999.0 0.0 -0.493 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.126 0.201 -9999.0 0.0 -0.366 92.0 92.0 SHH Np/Cholesterol/PTCH2 -0.15 0.21 -9999.0 0.0 -0.409 92.0 92.0 SHH Np/Cholesterol/Megalin -0.18 0.232 -9999.0 0.0 -0.434 101.0 101.0 SHH -0.195 0.264 -9999.0 0.0 -0.523 91.0 91.0 catabolic process 0.024 0.078 -9999.0 0.0 -0.475 2.0 2.0 SMO/Vitamin D3 -0.11 0.19 -9999.0 0.0 -0.333 93.0 93.0 SHH Np/Cholesterol/Hhip -0.176 0.215 -9999.0 0.0 -0.433 91.0 91.0 LRP2 -0.041 0.179 -9999.0 0.0 -0.697 16.0 16.0 receptor-mediated endocytosis -0.113 0.187 -9999.0 0.0 -0.534 10.0 10.0 SHH Np/Cholesterol/BOC -0.168 0.209 -9999.0 0.0 -0.418 92.0 92.0 SHH Np/Cholesterol/CDO -0.148 0.21 -9999.0 0.0 -0.409 91.0 91.0 mesenchymal cell differentiation 0.175 0.213 0.43 91.0 -9999.0 0.0 91.0 mol:Vitamin D3 -0.124 0.202 -9999.0 0.0 -0.364 92.0 92.0 IHH N/PTCH2 0.014 0.055 -9999.0 0.0 -0.429 2.0 2.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.026 0.079 -9999.0 0.0 -0.48 2.0 2.0 Megalin/LRPAP1 -0.022 0.136 -9999.0 0.0 -0.522 16.0 16.0 PTCH2 0.009 0.046 -9999.0 0.0 -0.697 1.0 1.0 SHH Np/Cholesterol -0.155 0.209 -9999.0 0.0 -0.415 91.0 91.0 PTCH1 0.024 0.078 -9999.0 0.0 -0.477 2.0 2.0 HHIP -0.046 0.122 -9999.0 0.0 -0.301 43.0 43.0