E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.019 0.029 -9999.0 0.0 -0.281 2.0 2.0 KLHL20 0.03 0.053 0.15 2.0 -0.208 2.0 4.0 CYFIP2 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.058 0.071 0.205 10.0 -9999.0 0.0 10.0 ENAH 0.018 0.029 -9999.0 0.0 -0.281 2.0 2.0 AP1M1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.017 0.018 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.02 -9999.0 0.0 -0.162 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.037 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.047 0.076 0.275 3.0 -0.283 1.0 4.0 CTNND1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.026 0.03 -9999.0 0.0 -0.287 2.0 2.0 CRK 0.047 0.073 0.176 51.0 -0.3 1.0 52.0 E-cadherin/gamma catenin/alpha catenin 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.024 0.039 -9999.0 0.0 -0.182 7.0 7.0 IQGAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.019 0.029 -9999.0 0.0 -0.281 2.0 2.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.004 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.023 0.065 -9999.0 0.0 -0.178 19.0 19.0 PI3K 0.008 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 -0.001 0.083 -9999.0 0.0 -0.288 18.0 18.0 E-cadherin(dimer)/Ca2+ 0.055 0.012 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.02 0.043 0.099 14.0 -9999.0 0.0 14.0 PIK3R1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.073 0.074 0.217 9.0 -9999.0 0.0 9.0 actin cytoskeleton organization 0.039 0.055 0.165 18.0 -0.172 1.0 19.0 CDC42/GDP 0.068 0.073 0.225 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.014 0.053 -9999.0 0.0 -0.288 7.0 7.0 RAC1 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.059 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.042 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.065 0.081 0.221 9.0 -9999.0 0.0 9.0 CDC42/GTP/IQGAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.08 0.073 0.22 8.0 -9999.0 0.0 8.0 RAC1/GTP/IQGAP1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.036 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.031 0.046 0.125 19.0 -0.144 5.0 24.0 NME1 0.015 0.068 0.314 1.0 -0.383 6.0 7.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.018 0.029 -9999.0 0.0 -0.281 2.0 2.0 regulation of cell-cell adhesion 0.011 0.014 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.014 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.068 0.066 0.164 71.0 -9999.0 0.0 71.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.054 0.041 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.035 0.053 0.143 18.0 -0.176 5.0 23.0 VAV2 0.074 0.095 -9999.0 0.0 -0.507 2.0 2.0 RAP1/GDP 0.078 0.073 0.195 27.0 -9999.0 0.0 27.0 adherens junction assembly 0.018 0.028 -9999.0 0.0 -0.274 2.0 2.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.037 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.012 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.013 0.024 -9999.0 0.0 -0.314 1.0 1.0 PIK3CA 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.001 0.048 -9999.0 0.0 -0.33 2.0 2.0 E-cadherin/beta catenin/alpha catenin 0.048 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.031 -9999.0 0.0 -0.292 2.0 2.0