Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.002 0.099 0.263 28.0 -0.205 1.0 29.0 KIRREL 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.001 0.099 0.206 1.0 -0.263 28.0 29.0 PLCG1 0.015 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.024 0.086 0.201 1.0 -0.2 26.0 27.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.009 0.041 0.148 1.0 -0.182 4.0 5.0 FYN -0.012 0.076 0.211 11.0 -0.166 29.0 40.0 mol:Ca2+ 0.011 0.073 -9999.0 0.0 -0.2 19.0 19.0 mol:DAG 0.012 0.073 -9999.0 0.0 -0.201 19.0 19.0 NPHS2 -0.009 0.05 -9999.0 0.0 -0.379 3.0 3.0 mol:IP3 0.012 0.073 -9999.0 0.0 -0.201 19.0 19.0 regulation of endocytosis 0.014 0.069 0.183 1.0 -0.16 24.0 25.0 Nephrin/NEPH1/podocin/Cholesterol 0.011 0.08 0.185 1.0 -0.192 29.0 30.0 establishment of cell polarity -0.002 0.099 0.205 1.0 -0.263 28.0 29.0 Nephrin/NEPH1/podocin/NCK1-2 0.036 0.084 -9999.0 0.0 -0.191 13.0 13.0 Nephrin/NEPH1/beta Arrestin2 0.015 0.07 0.19 1.0 -0.162 24.0 25.0 NPHS1 -0.023 0.129 0.279 1.0 -0.38 26.0 27.0 Nephrin/NEPH1/podocin 0.015 0.071 0.187 1.0 -0.167 29.0 30.0 TJP1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.012 0.074 -9999.0 0.0 -0.202 19.0 19.0 CD2AP 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.023 0.086 0.201 1.0 -0.196 28.0 29.0 GRB2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.016 0.079 0.211 10.0 -0.182 27.0 37.0 cytoskeleton organization -0.004 0.049 0.177 2.0 -0.246 1.0 3.0 Nephrin/NEPH1 0.004 0.069 0.169 1.0 -0.177 28.0 29.0 Nephrin/NEPH1/ZO-1 0.014 0.084 0.196 1.0 -0.208 27.0 28.0