Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.014 0.08 -9999.0 0.0 -0.34 9.0 9.0 IHH 0.026 0.035 -9999.0 0.0 -0.412 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.075 0.123 0.179 3.0 -0.212 98.0 101.0 LRPAP1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.075 0.122 0.211 98.0 -0.178 3.0 101.0 SMO/beta Arrestin2 0.004 0.073 -9999.0 0.0 -0.403 2.0 2.0 SMO -0.006 0.067 -9999.0 0.0 -0.42 2.0 2.0 AKT1 -0.005 0.096 -9999.0 0.0 -0.349 12.0 12.0 ARRB2 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.017 0.105 -9999.0 0.0 -0.288 30.0 30.0 ADRBK1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.006 0.067 -9999.0 0.0 -0.414 2.0 2.0 STIL -0.049 0.11 0.185 9.0 -0.29 6.0 15.0 DHH N/PTCH2 0.02 0.057 -9999.0 0.0 -0.202 14.0 14.0 DHH N/PTCH1 0.021 0.068 -9999.0 0.0 -0.338 2.0 2.0 PIK3CA 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.005 0.072 -9999.0 0.0 -0.288 13.0 13.0 PTHLH 0.011 0.09 -9999.0 0.0 -0.694 2.0 2.0 determination of left/right symmetry -0.006 0.067 -9999.0 0.0 -0.414 2.0 2.0 PIK3R1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.011 0.09 -9999.0 0.0 -0.687 2.0 2.0 IHH N/Hhip -0.016 0.107 -9999.0 0.0 -0.226 46.0 46.0 DHH N/Hhip -0.02 0.103 -9999.0 0.0 -0.21 51.0 51.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.006 0.067 -9999.0 0.0 -0.414 2.0 2.0 pancreas development -0.034 0.12 -9999.0 0.0 -0.287 42.0 42.0 HHAT 0.022 0.021 -9999.0 0.0 -0.288 1.0 1.0 PI3K 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.104 -9999.0 0.0 -0.302 26.0 26.0 somite specification -0.006 0.067 -9999.0 0.0 -0.414 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.05 0.11 0.186 5.0 -0.302 6.0 11.0 SHH Np/Cholesterol/PTCH2 -0.059 0.113 0.179 4.0 -0.204 85.0 89.0 SHH Np/Cholesterol/Megalin -0.073 0.125 0.174 5.0 -0.218 94.0 99.0 SHH -0.085 0.144 0.264 5.0 -0.27 84.0 89.0 catabolic process 0.02 0.059 -9999.0 0.0 -0.377 2.0 2.0 SMO/Vitamin D3 -0.045 0.104 -9999.0 0.0 -0.299 6.0 6.0 SHH Np/Cholesterol/Hhip -0.083 0.125 0.179 4.0 -0.226 83.0 87.0 LRP2 -0.02 0.101 -9999.0 0.0 -0.383 16.0 16.0 receptor-mediated endocytosis -0.05 0.099 -9999.0 0.0 -0.327 5.0 5.0 SHH Np/Cholesterol/BOC -0.076 0.121 0.179 5.0 -0.203 104.0 109.0 SHH Np/Cholesterol/CDO -0.058 0.113 0.179 4.0 -0.204 84.0 88.0 mesenchymal cell differentiation 0.083 0.124 0.224 83.0 -0.178 4.0 87.0 mol:Vitamin D3 -0.044 0.118 0.198 9.0 -0.302 6.0 15.0 IHH N/PTCH2 0.028 0.047 -9999.0 0.0 -0.205 8.0 8.0 CDON 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.027 0.062 -9999.0 0.0 -0.38 2.0 2.0 Megalin/LRPAP1 0.011 0.077 -9999.0 0.0 -0.27 16.0 16.0 PTCH2 0.022 0.027 -9999.0 0.0 -0.383 1.0 1.0 SHH Np/Cholesterol -0.066 0.103 -9999.0 0.0 -0.202 84.0 84.0 PTCH1 0.02 0.059 -9999.0 0.0 -0.378 2.0 2.0 HHIP -0.034 0.12 -9999.0 0.0 -0.288 42.0 42.0