Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Reelin signaling pathway	63.0	3539.0	56.0	-0.32	0.066	1000.0	-1000.0	-0.04	-1000.0
Ephrin A  reverse signaling	39.0	276.0	7.0	-0.043	-0.0	1000.0	-1000.0	-0.016	-1000.0
TCGA08_retinoblastoma	39.0	319.0	8.0	-0.096	0.054	1000.0	-1000.0	-0.001	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	38.0	2067.0	54.0	-0.32	0.033	1000.0	-1000.0	-0.045	-1000.0
Glypican 1 network	34.0	1671.0	48.0	-0.191	0.046	1000.0	-1000.0	-0.027	-1000.0
Osteopontin-mediated events	32.0	1238.0	38.0	-0.182	0.035	1000.0	-1000.0	-0.047	-1000.0
IL4-mediated signaling events	32.0	2990.0	91.0	-0.752	0.571	1000.0	-1000.0	-0.156	-1000.0
Syndecan-1-mediated signaling events	27.0	949.0	34.0	-0.373	0.024	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by the Hedgehog family	25.0	1338.0	52.0	-0.085	0.083	1000.0	-1000.0	-0.031	-1000.0
Signaling events regulated by Ret tyrosine kinase	25.0	2051.0	82.0	-0.099	0.024	1000.0	-1000.0	-0.048	-1000.0
BCR signaling pathway	25.0	2530.0	99.0	-0.151	0.03	1000.0	-1000.0	-0.051	-1000.0
HIF-1-alpha transcription factor network	24.0	1893.0	76.0	-0.481	0.034	1000.0	-1000.0	-0.109	-1000.0
FOXA2 and FOXA3 transcription factor networks	23.0	1092.0	46.0	-0.467	0.028	1000.0	-1000.0	-0.112	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	23.0	1817.0	78.0	-0.145	0.05	1000.0	-1000.0	-0.054	-1000.0
Fc-epsilon receptor I signaling in mast cells	22.0	2217.0	97.0	-0.128	0.044	1000.0	-1000.0	-0.06	-1000.0
p75(NTR)-mediated signaling	21.0	2677.0	125.0	-0.373	0.063	1000.0	-1000.0	-0.07	-1000.0
BMP receptor signaling	20.0	1700.0	81.0	-0.135	0.045	1000.0	-1000.0	-0.047	-1000.0
IL1-mediated signaling events	20.0	1277.0	62.0	-0.147	0.094	1000.0	-1000.0	-0.044	-1000.0
Endothelins	19.0	1857.0	96.0	-0.263	0.031	1000.0	-1000.0	-0.068	-1000.0
Visual signal transduction: Cones	18.0	713.0	38.0	-0.114	0.041	1000.0	-1000.0	-0.016	-1000.0
Syndecan-2-mediated signaling events	18.0	1259.0	69.0	-0.216	0.041	1000.0	-1000.0	-0.032	-1000.0
Wnt signaling	18.0	128.0	7.0	-0.058	0.021	1000.0	-1000.0	-0.014	-1000.0
Visual signal transduction: Rods	17.0	892.0	52.0	-0.162	0.025	1000.0	-1000.0	-0.034	-1000.0
amb2 Integrin signaling	16.0	1381.0	82.0	-0.073	0.041	1000.0	-1000.0	-0.028	-1000.0
TCGA08_p53	16.0	112.0	7.0	-0.072	0.031	1000.0	-1000.0	-0.007	-1000.0
LPA receptor mediated events	16.0	1698.0	102.0	-0.156	0.032	1000.0	-1000.0	-0.06	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	15.0	514.0	34.0	-0.023	0.036	1000.0	-1000.0	-0.028	-1000.0
Effects of Botulinum toxin	15.0	392.0	26.0	-0.075	0.037	1000.0	-1000.0	-0.008	-1000.0
Glypican 2 network	15.0	60.0	4.0	0.001	0.012	1000.0	-1000.0	0.003	-1000.0
Calcium signaling in the CD4+ TCR pathway	15.0	487.0	31.0	-0.221	0.024	1000.0	-1000.0	-0.041	-1000.0
Nongenotropic Androgen signaling	15.0	807.0	52.0	-0.121	0.045	1000.0	-1000.0	-0.039	-1000.0
Plasma membrane estrogen receptor signaling	15.0	1307.0	86.0	-0.263	0.078	1000.0	-1000.0	-0.051	-1000.0
Ras signaling in the CD4+ TCR pathway	15.0	255.0	17.0	-0.056	0.045	1000.0	-1000.0	-0.026	-1000.0
LPA4-mediated signaling events	14.0	173.0	12.0	-0.075	0.006	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	250.0	17.0	-0.125	0.039	1000.0	-1000.0	-0.026	-1000.0
Ephrin B reverse signaling	14.0	711.0	48.0	-0.071	0.026	1000.0	-1000.0	-0.021	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1361.0	93.0	-0.028	0.035	1000.0	-1000.0	-0.047	-1000.0
Syndecan-4-mediated signaling events	14.0	943.0	67.0	-0.275	0.053	1000.0	-1000.0	-0.031	-1000.0
Canonical Wnt signaling pathway	13.0	677.0	51.0	-0.194	0.107	1000.0	-1000.0	-0.049	-1000.0
EGFR-dependent Endothelin signaling events	13.0	275.0	21.0	-0.061	0.035	1000.0	-1000.0	-0.04	-1000.0
PDGFR-beta signaling pathway	13.0	1335.0	97.0	-0.144	0.08	1000.0	-1000.0	-0.053	-1000.0
Noncanonical Wnt signaling pathway	12.0	318.0	26.0	-0.058	0.023	1000.0	-1000.0	-0.04	-1000.0
S1P5 pathway	12.0	211.0	17.0	-0.115	0.06	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-alpha and p38-beta	12.0	567.0	44.0	-0.041	0.024	1000.0	-1000.0	-0.024	-1000.0
EPHB forward signaling	12.0	1052.0	85.0	-0.073	0.08	1000.0	-1000.0	-0.061	-1000.0
Angiopoietin receptor Tie2-mediated signaling	12.0	1073.0	88.0	-0.125	0.057	1000.0	-1000.0	-0.068	-1000.0
Coregulation of Androgen receptor activity	11.0	843.0	76.0	-0.235	0.063	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	11.0	493.0	43.0	-0.267	0.156	1000.0	-1000.0	-0.063	-1000.0
IGF1 pathway	11.0	652.0	57.0	-0.042	0.046	1000.0	-1000.0	-0.033	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	11.0	1407.0	120.0	-0.095	0.088	1000.0	-1000.0	-0.045	-1000.0
S1P4 pathway	11.0	278.0	25.0	-0.115	0.037	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	10.0	677.0	62.0	-0.127	0.05	1000.0	-1000.0	-0.032	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	666.0	61.0	-0.194	0.101	1000.0	-1000.0	-0.046	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	10.0	567.0	52.0	-0.135	0.054	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	10.0	360.0	36.0	-0.116	0.024	1000.0	-1000.0	-0.044	-1000.0
Syndecan-3-mediated signaling events	10.0	363.0	35.0	-0.216	0.063	1000.0	-1000.0	-0.021	-1000.0
Integrins in angiogenesis	10.0	844.0	84.0	-0.182	0.058	1000.0	-1000.0	-0.042	-1000.0
IL23-mediated signaling events	10.0	648.0	60.0	-0.3	0.032	1000.0	-1000.0	-0.119	-1000.0
Caspase cascade in apoptosis	9.0	688.0	74.0	-0.097	0.058	1000.0	-1000.0	-0.041	-1000.0
PLK1 signaling events	9.0	838.0	85.0	-0.008	0.053	1000.0	-1000.0	-0.024	-1000.0
Ceramide signaling pathway	9.0	703.0	76.0	-0.061	0.062	1000.0	-1000.0	-0.033	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	239.0	28.0	-0.115	0.031	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	8.0	864.0	105.0	-0.117	0.06	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PTP1B	8.0	636.0	76.0	-0.199	0.041	1000.0	-1000.0	-0.035	-1000.0
Nectin adhesion pathway	8.0	566.0	63.0	-0.353	0.066	1000.0	-1000.0	-0.041	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	545.0	68.0	-0.238	0.035	1000.0	-1000.0	-0.085	-1000.0
VEGFR1 specific signals	8.0	464.0	56.0	-0.014	0.083	1000.0	-1000.0	-0.044	-1000.0
S1P3 pathway	8.0	365.0	42.0	-0.115	0.04	1000.0	-1000.0	-0.04	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	285.0	33.0	-0.092	0.059	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PRL	8.0	294.0	34.0	-0.062	0.073	1000.0	-1000.0	-0.038	-1000.0
Glucocorticoid receptor regulatory network	7.0	908.0	114.0	-0.265	0.179	1000.0	-1000.0	-0.055	-1000.0
Regulation of p38-alpha and p38-beta	7.0	385.0	54.0	-0.078	0.046	1000.0	-1000.0	-0.043	-1000.0
Regulation of Androgen receptor activity	7.0	550.0	70.0	-0.254	0.044	1000.0	-1000.0	-0.048	-1000.0
Aurora B signaling	7.0	495.0	67.0	-0.419	0.091	1000.0	-1000.0	-0.034	-1000.0
IL12-mediated signaling events	6.0	548.0	87.0	-0.077	0.048	1000.0	-1000.0	-0.092	-1000.0
ErbB4 signaling events	6.0	426.0	69.0	-0.185	0.074	1000.0	-1000.0	-0.046	-1000.0
PLK2 and PLK4 events	6.0	18.0	3.0	-0.0	0.023	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	6.0	332.0	55.0	0.004	0.066	1000.0	-1000.0	-0.043	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	735.0	136.0	-0.208	0.054	1000.0	-1000.0	-0.044	-1000.0
Cellular roles of Anthrax toxin	5.0	224.0	39.0	-0.037	0.026	1000.0	-1000.0	-0.018	-1000.0
PDGFR-alpha signaling pathway	5.0	258.0	44.0	-0.011	0.054	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	192.0	37.0	-0.145	0.059	1000.0	-1000.0	-0.029	-1000.0
FAS signaling pathway (CD95)	5.0	251.0	47.0	-0.015	0.036	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	75.0	15.0	-0.05	0.024	1000.0	-1000.0	-0.035	-1000.0
Retinoic acid receptors-mediated signaling	5.0	319.0	58.0	-0.154	0.046	1000.0	-1000.0	-0.035	-1000.0
Class I PI3K signaling events	5.0	384.0	73.0	-0.078	0.041	1000.0	-1000.0	-0.041	-1000.0
ErbB2/ErbB3 signaling events	4.0	294.0	65.0	-0.056	0.035	1000.0	-1000.0	-0.053	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	22.0	5.0	0.014	0.033	1000.0	-1000.0	-0.002	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	421.0	85.0	-0.026	0.052	1000.0	-1000.0	-0.042	-1000.0
Insulin-mediated glucose transport	4.0	131.0	32.0	-0.135	0.04	1000.0	-1000.0	-0.033	-1000.0
IFN-gamma pathway	4.0	309.0	68.0	-0.04	0.035	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	283.0	68.0	-0.049	0.058	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class III	4.0	165.0	40.0	-0.058	0.046	1000.0	-1000.0	-0.016	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	382.0	83.0	-0.158	0.059	1000.0	-1000.0	-0.04	-1000.0
FoxO family signaling	4.0	303.0	64.0	-0.085	0.058	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	519.0	125.0	-0.014	0.084	1000.0	-1000.0	-0.04	-1000.0
IL6-mediated signaling events	4.0	345.0	75.0	-0.027	0.078	1000.0	-1000.0	-0.067	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	359.0	76.0	-0.005	0.08	1000.0	-1000.0	-0.051	-1000.0
Arf6 trafficking events	4.0	297.0	71.0	-0.042	0.043	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	238.0	65.0	-0.115	0.047	1000.0	-1000.0	-0.047	-1000.0
Aurora A signaling	3.0	233.0	60.0	-0.111	0.067	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	3.0	155.0	43.0	-0.024	0.038	1000.0	-1000.0	-0.028	-1000.0
ceramide signaling pathway	3.0	151.0	49.0	0.0	0.04	1000.0	-1000.0	-0.038	-1000.0
Atypical NF-kappaB pathway	3.0	94.0	31.0	0.0	0.049	1000.0	-1000.0	-0.018	-1000.0
IL27-mediated signaling events	3.0	200.0	51.0	-0.047	0.038	1000.0	-1000.0	-0.05	-1000.0
TCGA08_rtk_signaling	3.0	87.0	26.0	-0.023	0.054	1000.0	-1000.0	-0.017	-1000.0
Regulation of Telomerase	3.0	396.0	102.0	-0.149	0.057	1000.0	-1000.0	-0.052	-1000.0
FOXM1 transcription factor network	3.0	202.0	51.0	-0.097	0.059	1000.0	-1000.0	-0.172	-1000.0
Canonical NF-kappaB pathway	2.0	91.0	39.0	-0.019	0.052	1000.0	-1000.0	-0.03	-1000.0
mTOR signaling pathway	2.0	120.0	53.0	-0.05	0.035	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by PI3K	2.0	124.0	58.0	-0.024	0.041	1000.0	-1000.0	-0.048	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	126.0	45.0	-0.003	0.067	1000.0	-1000.0	-0.043	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	209.0	74.0	-0.061	0.055	1000.0	-1000.0	-0.06	-1000.0
Rapid glucocorticoid signaling	2.0	49.0	20.0	-0.016	0.027	1000.0	-1000.0	-0.005	-1000.0
p38 MAPK signaling pathway	2.0	127.0	44.0	-0.035	0.054	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	1.0	122.0	75.0	-0.018	0.065	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	1.0	70.0	57.0	-0.047	0.064	1000.0	-1000.0	-0.038	-1000.0
TRAIL signaling pathway	1.0	77.0	48.0	-0.022	0.054	1000.0	-1000.0	-0.033	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	40.0	36.0	-0.049	0.051	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by STAT5	1.0	38.0	22.0	-0.005	0.037	1000.0	-1000.0	-0.045	-1000.0
Insulin Pathway	1.0	144.0	74.0	-0.019	0.074	1000.0	-1000.0	-0.049	-1000.0
Arf1 pathway	1.0	98.0	54.0	-0.001	0.045	1000.0	-1000.0	-0.017	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	0.011	0.039	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.007	0.055	1000.0	-1000.0	-0.039	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.037	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class I	0.0	65.0	104.0	-0.047	0.058	1000.0	-1000.0	-0.028	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.049	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in keratinocytes	0.0	28.0	43.0	-0.041	0.077	1000.0	-1000.0	-0.035	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.024	0.024	1000.0	-1000.0	-0.006	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.024	0.047	1000.0	-1000.0	-0.003	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.066	1000.0	-1000.0	-0.0	-1000.0
Total	1360	79962	7203	-14.9207983496	7.15776585205	131000	-131000	-5.24756751246	-131000