Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	160 (72%)	63	0.0075952	1	0.026727	1	0.071971	1	NA	NA	0.46688	1	0.45244	1	0.34002	1	0.8373	1
FBXW7	38 (17%)	185	0.059212	1	0.043687	1	0.0004943	0.0766	NA	NA	0.01122	1	0.03617	1	0.41557	1	0.15614	1
NRAS	20 (9%)	203	0.046463	1	0.12488	1	0.095738	1	NA	NA	0.90948	1	0.47408	1	0.26773	1	1	1
BRAF	22 (10%)	201	9.1287e-07	0.000147	2.3101e-08	3.74e-06	9.5618e-05	0.015	NA	NA	0.48227	1	0.30406	1	1	1	0.68359	1
KRAS	96 (43%)	127	7.4452e-05	0.0118	4.0502e-05	0.00644	0.43027	1	0.10714	1	0.57241	1	1	1	0.021757	1	0.043066	1
TP53	119 (53%)	104	0.0020178	0.311	0.00048185	0.0752	2.0097e-12	3.28e-10	NA	NA	0.5679	1	0.78239	1	0.030673	1	0.56715	1
SMAD4	26 (12%)	197	0.030844	1	0.28789	1	0.12785	1	NA	NA	0.85909	1	0.33919	1	1	1	1	1
FAM123B	25 (11%)	198	0.072343	1	0.091812	1	0.0055829	0.843	NA	NA	0.34449	1	0.5876	1	1	1	1	1
PIK3CA	33 (15%)	190	0.20484	1	0.56994	1	2.1339e-05	0.00341	NA	NA	0.062025	1	0.12884	1	0.16455	1	1	1
SMAD2	15 (7%)	208	0.13307	1	0.51785	1	0.35304	1	NA	NA	0.59205	1	0.13321	1	1	1	1	1
TCF7L2	18 (8%)	205	1	1	0.41298	1	0.0072292	1	NA	NA	0.8363	1	0.89617	1	1	1	1	1
ACVR2A	9 (4%)	214	0.0071729	1	0.18431	1	0.02072	1	NA	NA	0.095237	1	0.46856	1	0.17286	1	1	1
SOX9	10 (4%)	213	0.12913	1	0.12286	1	0.0050171	0.763	NA	NA	0.18915	1	0.694	1	1	1	1	1
ELF3	6 (3%)	217	0.36312	1	0.81051	1	0.52138	1	NA	NA	0.54372	1	0.43551	1	1	1	1	1
CRTC1	6 (3%)	217	0.12306	1	0.16488	1	0.89821	1	NA	NA	0.17545	1	0.48214	1	1	1	1	1
TNFRSF10C	6 (3%)	217	0.31707	1	0.28709	1	0.16464	1	NA	NA	0.27762	1	0.378	1	1	1	1	1
KIAA1804	15 (7%)	208	0.26731	1	0.39731	1	0.078927	1	NA	NA	0.50609	1	0.47408	1	1	1	1	1
KRTAP5-5	4 (2%)	219	0.3272	1	0.48238	1	0.84921	1	NA	NA	0.38532	1	1	1	1	1	1	1
PTEN	7 (3%)	216	0.027588	1	0.33674	1	0.051728	1	NA	NA	0.54372	1	0.43551	1	0.34726	1	0.29788	1
ACOT4	3 (1%)	220	0.25523	1	0.48995	1	0.51487	1	NA	NA	NA	NA	NA	NA	1	1	1	1
MYO1B	13 (6%)	210	0.0086213	1	0.0087863	1	0.0046347	0.709	NA	NA	0.021464	1	0.46856	1	1	1	1	1
PCBP1	6 (3%)	217	0.23388	1	0.81051	1	0.70696	1	NA	NA	0.64843	1	0.48214	1	1	1	1	1
GGT1	3 (1%)	220	NA	NA	NA	NA	0.17515	1	NA	NA	NA	NA	NA	NA	1	1	1	1
ACVR1B	14 (6%)	209	0.37438	1	0.31631	1	0.092415	1	NA	NA	0.7346	1	0.37567	1	0.58058	1	1	1