E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 KLHL20 -0.02 0.051 -9999.0 0.0 -0.234 11.0 11.0 CYFIP2 0.002 0.082 -9999.0 0.0 -0.649 5.0 5.0 Rac1/GDP 0.053 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.03 0.05 -9999.0 0.0 -9999.0 0.0 0.0 AP1M1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.002 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.014 0.037 -9999.0 0.0 -0.195 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.012 0.082 -9999.0 0.0 -0.369 11.0 11.0 RAPGEF1 0.046 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.031 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.042 0.02 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin 0.024 0.024 -9999.0 0.0 -0.405 1.0 1.0 alphaE/beta7 Integrin -0.007 0.103 -9999.0 0.0 -0.404 19.0 19.0 IQGAP1 0.011 0.025 -9999.0 0.0 -0.428 1.0 1.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.021 0.031 -9999.0 0.0 -0.37 2.0 2.0 DLG1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.002 0.021 -9999.0 0.0 -0.342 1.0 1.0 MLLT4 0.008 0.052 -9999.0 0.0 -0.648 2.0 2.0 ARF6/GTP/NME1/Tiam1 -0.025 0.121 -9999.0 0.0 -0.37 28.0 28.0 PI3K -0.003 0.029 -9999.0 0.0 -0.471 1.0 1.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 -0.071 0.207 -9999.0 0.0 -0.562 46.0 46.0 E-cadherin(dimer)/Ca2+ 0.028 0.021 -9999.0 0.0 -0.343 1.0 1.0 AKT1 -0.001 0.015 -9999.0 0.0 -0.241 1.0 1.0 PIK3R1 0.01 0.037 -9999.0 0.0 -0.649 1.0 1.0 CDH1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.053 0.029 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.02 0.052 -9999.0 0.0 -0.17 11.0 11.0 CDC42/GDP 0.053 0.029 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.022 0.017 -9999.0 0.0 -0.285 1.0 1.0 ITGB7 -0.021 0.135 -9999.0 0.0 -0.544 19.0 19.0 RAC1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.022 -9999.0 0.0 -0.363 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.021 0.021 -9999.0 0.0 -0.35 1.0 1.0 mol:GDP 0.05 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 0.016 0.015 -9999.0 0.0 -0.246 1.0 1.0 JUP 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.016 0.015 -9999.0 0.0 -0.246 1.0 1.0 PIP5K1C/AP1M1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.01 0.037 -9999.0 0.0 -0.648 1.0 1.0 positive regulation of S phase of mitotic cell cycle 0.018 0.034 -9999.0 0.0 -9999.0 0.0 0.0 NME1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.007 0.019 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.002 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.016 0.079 -9999.0 0.0 -0.342 12.0 12.0 CCND1 0.021 0.041 -9999.0 0.0 -9999.0 0.0 0.0 VAV2 0.023 0.132 -9999.0 0.0 -0.701 10.0 10.0 RAP1/GDP 0.04 0.027 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.023 0.076 -9999.0 0.0 -0.378 1.0 1.0 E-cadherin/beta catenin 0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.01 0.037 -9999.0 0.0 -0.649 1.0 1.0 Rac1/GTP -0.03 0.079 -9999.0 0.0 -0.373 10.0 10.0 E-cadherin/beta catenin/alpha catenin 0.024 0.024 -9999.0 0.0 -0.405 1.0 1.0 ITGAE 0.011 0.025 -9999.0 0.0 -0.428 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0