Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.055 0.231 -9999.0 0.0 -0.661 28.0 28.0 IHH -0.046 0.191 -9999.0 0.0 -0.694 24.0 24.0 SHH Np/Cholesterol/GAS1 -0.089 0.179 -9999.0 0.0 -0.399 67.0 67.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.088 0.178 0.396 67.0 -9999.0 0.0 67.0 SMO/beta Arrestin2 -0.047 0.222 -9999.0 0.0 -0.695 23.0 23.0 SMO -0.056 0.235 -9999.0 0.0 -0.714 25.0 25.0 AKT1 -0.005 0.12 -9999.0 0.0 -0.487 6.0 6.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.068 0.194 -9999.0 0.0 -0.515 48.0 48.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.054 0.23 -9999.0 0.0 -0.622 33.0 33.0 STIL -0.026 0.176 -9999.0 0.0 -0.637 16.0 16.0 DHH N/PTCH2 -0.065 0.194 -9999.0 0.0 -0.475 53.0 53.0 DHH N/PTCH1 -0.063 0.2 -9999.0 0.0 -0.508 31.0 31.0 PIK3CA 0.01 0.037 -9999.0 0.0 -0.649 1.0 1.0 DHH -0.046 0.181 -9999.0 0.0 -0.597 30.0 30.0 PTHLH -0.084 0.311 -9999.0 0.0 -0.959 28.0 28.0 determination of left/right symmetry -0.054 0.23 -9999.0 0.0 -0.622 33.0 33.0 PIK3R1 0.01 0.037 -9999.0 0.0 -0.649 1.0 1.0 skeletal system development -0.083 0.306 -9999.0 0.0 -0.943 28.0 28.0 IHH N/Hhip -0.115 0.236 -9999.0 0.0 -0.486 83.0 83.0 DHH N/Hhip -0.115 0.221 -9999.0 0.0 -0.443 91.0 91.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.054 0.23 -9999.0 0.0 -0.622 33.0 33.0 pancreas development -0.112 0.242 -9999.0 0.0 -0.563 68.0 68.0 HHAT 0.006 0.064 -9999.0 0.0 -0.649 3.0 3.0 PI3K 0.015 0.05 -9999.0 0.0 -0.873 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.149 0.265 -9999.0 0.0 -0.566 88.0 88.0 somite specification -0.054 0.23 -9999.0 0.0 -0.622 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.034 0.185 -9999.0 0.0 -0.658 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.029 0.129 -9999.0 0.0 -0.376 34.0 34.0 SHH Np/Cholesterol/Megalin -0.023 0.105 -9999.0 0.0 -0.401 15.0 15.0 SHH -0.003 0.106 -9999.0 0.0 -0.479 15.0 15.0 catabolic process -0.039 0.182 -9999.0 0.0 -0.47 31.0 31.0 SMO/Vitamin D3 -0.045 0.216 -9999.0 0.0 -0.689 23.0 23.0 SHH Np/Cholesterol/Hhip -0.068 0.165 -9999.0 0.0 -0.394 54.0 54.0 LRP2 -0.027 0.118 -9999.0 0.0 -0.428 25.0 25.0 receptor-mediated endocytosis -0.046 0.207 -9999.0 0.0 -0.678 21.0 21.0 SHH Np/Cholesterol/BOC -0.041 0.138 -9999.0 0.0 -0.387 33.0 33.0 SHH Np/Cholesterol/CDO -0.005 0.099 -9999.0 0.0 -0.381 19.0 19.0 mesenchymal cell differentiation 0.068 0.164 0.392 54.0 -9999.0 0.0 54.0 mol:Vitamin D3 -0.032 0.187 -9999.0 0.0 -0.662 17.0 17.0 IHH N/PTCH2 -0.061 0.192 -9999.0 0.0 -0.48 50.0 50.0 CDON -0.003 0.091 -9999.0 0.0 -0.526 9.0 9.0 IHH N/PTCH1 -0.038 0.184 -9999.0 0.0 -0.476 31.0 31.0 Megalin/LRPAP1 -0.01 0.083 -9999.0 0.0 -0.294 25.0 25.0 PTCH2 -0.044 0.174 -9999.0 0.0 -0.563 31.0 31.0 SHH Np/Cholesterol -0.018 0.08 -9999.0 0.0 -0.377 15.0 15.0 PTCH1 -0.039 0.182 -9999.0 0.0 -0.472 31.0 31.0 HHIP -0.112 0.242 -9999.0 0.0 -0.564 68.0 68.0