Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.027 0.017 -9999.0 0.0 -0.278 1.0 1.0 epithelial cell differentiation -0.001 0.019 -9999.0 0.0 -0.34 1.0 1.0 CYFIP2 0.002 0.082 -9999.0 0.0 -0.649 5.0 5.0 ENAH 0.047 0.053 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.005 0.063 -9999.0 0.0 -0.538 4.0 4.0 EPHA2 0.004 0.069 -9999.0 0.0 -0.593 4.0 4.0 MYO6 0.033 0.02 -9999.0 0.0 -0.32 1.0 1.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.018 0.054 -9999.0 0.0 -0.405 5.0 5.0 AQP5 -0.053 0.128 -9999.0 0.0 -0.499 22.0 22.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.033 0.02 -9999.0 0.0 -0.315 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.007 0.111 -9999.0 0.0 -0.331 28.0 28.0 EGF -0.191 0.265 -9999.0 0.0 -0.517 121.0 121.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.023 0.071 -9999.0 0.0 -0.499 5.0 5.0 cortical microtubule organization -0.001 0.019 -9999.0 0.0 -0.34 1.0 1.0 GO:0000145 0.031 0.019 -9999.0 0.0 -0.301 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.028 0.021 -9999.0 0.0 -0.343 1.0 1.0 MLLT4 0.008 0.052 -9999.0 0.0 -0.649 2.0 2.0 ARF6/GDP -0.004 0.031 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.026 0.043 -9999.0 0.0 -0.363 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.042 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.033 0.02 -9999.0 0.0 -0.32 1.0 1.0 ARF6/GTP -0.004 0.035 -9999.0 0.0 -0.332 3.0 3.0 CDH1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.09 0.121 -9999.0 0.0 -0.436 2.0 2.0 RhoA/GDP -0.001 0.018 -9999.0 0.0 -0.317 1.0 1.0 actin cytoskeleton organization 0.038 0.019 -9999.0 0.0 -0.304 1.0 1.0 IGF-1R heterotetramer 0.01 0.037 -9999.0 0.0 -0.647 1.0 1.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.037 -9999.0 0.0 -0.649 1.0 1.0 IGF1 -0.102 0.226 -9999.0 0.0 -0.527 67.0 67.0 DIAPH1 -0.01 0.076 -9999.0 0.0 -0.609 5.0 5.0 Wnt receptor signaling pathway 0.001 0.019 0.34 1.0 -9999.0 0.0 1.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.004 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.01 0.037 -9999.0 0.0 -0.649 1.0 1.0 VCL 0.038 0.02 -9999.0 0.0 -0.311 1.0 1.0 EFNA1 0.011 0.025 -9999.0 0.0 -0.428 1.0 1.0 LPP 0.038 0.022 -9999.0 0.0 -0.3 1.0 1.0 Ephrin A1/EPHA2 -0.005 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.003 0.027 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.008 0.112 -9999.0 0.0 -0.337 28.0 28.0 HGF/MET -0.036 0.093 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.067 0.204 -9999.0 0.0 -0.572 43.0 43.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.027 0.017 -9999.0 0.0 -0.28 1.0 1.0 actin cable formation 0.063 0.04 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.037 0.027 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.027 0.048 -9999.0 0.0 -0.324 5.0 5.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.033 0.02 -9999.0 0.0 -0.32 1.0 1.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.019 -9999.0 0.0 -0.34 1.0 1.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.033 0.02 -9999.0 0.0 -0.32 1.0 1.0 PIP5K1C 0.033 0.02 -9999.0 0.0 -0.32 1.0 1.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.05 0.039 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.045 0.055 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.051 0.105 -9999.0 0.0 -0.637 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.015 0.039 -9999.0 0.0 -0.478 2.0 2.0 MET 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.032 0.028 -9999.0 0.0 -0.322 2.0 2.0 mol:GTP 0.025 0.042 -9999.0 0.0 -0.361 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.052 0.031 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.027 0.017 -9999.0 0.0 -0.278 1.0 1.0 regulation of cell-cell adhesion 0.038 0.019 -9999.0 0.0 -0.304 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.027 0.017 -9999.0 0.0 -0.28 1.0 1.0