E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.022 0.029 -9999.0 0.0 -0.319 1.0 1.0 KLHL20 0.026 0.071 -9999.0 0.0 -0.233 11.0 11.0 CYFIP2 0.016 0.069 -9999.0 0.0 -0.53 5.0 5.0 Rac1/GDP 0.066 0.078 0.318 1.0 -9999.0 0.0 1.0 ENAH 0.017 0.045 -9999.0 0.0 -0.319 1.0 1.0 AP1M1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.001 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.016 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.012 0.035 -9999.0 0.0 -0.162 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.064 -9999.0 0.0 -0.29 9.0 9.0 RAPGEF1 0.057 0.079 0.336 1.0 -9999.0 0.0 1.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.028 0.031 -9999.0 0.0 -0.327 1.0 1.0 CRK 0.009 0.026 -9999.0 0.0 -0.303 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.047 0.024 -9999.0 0.0 -0.33 1.0 1.0 alphaE/beta7 Integrin 0.014 0.077 -9999.0 0.0 -0.362 11.0 11.0 IQGAP1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.045 0.023 -9999.0 0.0 -0.3 1.0 1.0 DLG1 0.022 0.029 -9999.0 0.0 -0.319 1.0 1.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.003 0.021 -9999.0 0.0 -0.28 1.0 1.0 MLLT4 0.023 0.031 -9999.0 0.0 -0.529 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.008 0.097 -9999.0 0.0 -0.298 25.0 25.0 PI3K 0.006 0.028 -9999.0 0.0 -0.374 1.0 1.0 ARF6 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 -0.035 0.159 -9999.0 0.0 -0.389 45.0 45.0 E-cadherin(dimer)/Ca2+ 0.056 0.023 -9999.0 0.0 -0.284 1.0 1.0 AKT1 0.033 0.044 -9999.0 0.0 -0.206 1.0 1.0 PIK3R1 0.022 0.032 -9999.0 0.0 -0.53 1.0 1.0 CDH1 0.025 0.001 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.078 0.081 0.285 2.0 -9999.0 0.0 2.0 actin cytoskeleton organization 0.034 0.065 0.171 19.0 -0.17 11.0 30.0 CDC42/GDP 0.074 0.08 0.285 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.019 0.016 -9999.0 0.0 -0.251 1.0 1.0 ITGB7 0.001 0.102 -9999.0 0.0 -0.363 19.0 19.0 RAC1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.06 0.025 -9999.0 0.0 -0.301 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.042 0.02 -9999.0 0.0 -0.282 1.0 1.0 mol:GDP 0.07 0.087 0.294 2.0 -9999.0 0.0 2.0 CDC42/GTP/IQGAP1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.086 0.08 0.287 2.0 -9999.0 0.0 2.0 RAC1/GTP/IQGAP1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.031 -9999.0 0.0 -0.529 1.0 1.0 positive regulation of S phase of mitotic cell cycle 0.03 0.047 0.133 20.0 -0.121 2.0 22.0 NME1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.022 0.03 -9999.0 0.0 -0.319 1.0 1.0 regulation of cell-cell adhesion 0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.012 0.031 -9999.0 0.0 -0.123 1.0 1.0 Rap1/GTP 0.075 0.071 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.067 -9999.0 0.0 -0.275 10.0 10.0 CCND1 0.033 0.054 0.151 18.0 -0.147 2.0 20.0 VAV2 0.06 0.161 -9999.0 0.0 -0.675 11.0 11.0 RAP1/GDP 0.085 0.078 0.295 2.0 -9999.0 0.0 2.0 adherens junction assembly 0.021 0.029 -9999.0 0.0 -0.31 1.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.036 0.065 -9999.0 0.0 -0.263 10.0 10.0 E-cadherin/beta catenin 0.013 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.014 0.027 -9999.0 0.0 -0.319 1.0 1.0 PIK3CA 0.023 0.031 -9999.0 0.0 -0.53 1.0 1.0 Rac1/GTP -0.02 0.074 -9999.0 0.0 -0.374 11.0 11.0 E-cadherin/beta catenin/alpha catenin 0.048 0.023 -9999.0 0.0 -0.33 1.0 1.0 ITGAE 0.021 0.014 -9999.0 0.0 -0.178 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.029 0.031 -9999.0 0.0 -0.333 1.0 1.0