Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.187 -9999.0 0.0 -0.59 26.0 26.0 IHH -0.029 0.164 -9999.0 0.0 -0.562 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.054 0.137 0.161 1.0 -0.318 61.0 62.0 LRPAP1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.054 0.136 0.316 61.0 -0.159 1.0 62.0 SMO/beta Arrestin2 -0.043 0.194 -9999.0 0.0 -0.521 34.0 34.0 SMO -0.053 0.2 -9999.0 0.0 -0.549 34.0 34.0 AKT1 -0.023 0.139 -9999.0 0.0 -0.421 18.0 18.0 ARRB2 0.021 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.028 0.14 -9999.0 0.0 -0.53 19.0 19.0 ADRBK1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.052 0.197 -9999.0 0.0 -0.539 34.0 34.0 STIL -0.023 0.15 -9999.0 0.0 -0.475 19.0 19.0 DHH N/PTCH2 -0.025 0.151 -9999.0 0.0 -0.409 38.0 38.0 DHH N/PTCH1 -0.038 0.168 -9999.0 0.0 -0.345 62.0 62.0 PIK3CA 0.023 0.031 -9999.0 0.0 -0.53 1.0 1.0 DHH -0.022 0.146 -9999.0 0.0 -0.448 30.0 30.0 PTHLH -0.069 0.266 -9999.0 0.0 -0.869 26.0 26.0 determination of left/right symmetry -0.052 0.197 -9999.0 0.0 -0.539 34.0 34.0 PIK3R1 0.022 0.032 -9999.0 0.0 -0.53 1.0 1.0 skeletal system development -0.068 0.263 -9999.0 0.0 -0.857 26.0 26.0 IHH N/Hhip -0.068 0.19 -9999.0 0.0 -0.439 58.0 58.0 DHH N/Hhip -0.064 0.178 -9999.0 0.0 -0.403 61.0 61.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.052 0.197 -9999.0 0.0 -0.539 34.0 34.0 pancreas development -0.063 0.186 -9999.0 0.0 -0.394 65.0 65.0 HHAT 0.019 0.054 -9999.0 0.0 -0.53 3.0 3.0 PI3K 0.033 0.042 -9999.0 0.0 -0.697 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.091 0.209 -9999.0 0.0 -0.399 86.0 86.0 somite specification -0.052 0.197 -9999.0 0.0 -0.539 34.0 34.0 SHH Np/Cholesterol/PTCH1 -0.029 0.15 -9999.0 0.0 -0.346 47.0 47.0 SHH Np/Cholesterol/PTCH2 -0.012 0.096 -9999.0 0.0 -0.302 29.0 29.0 SHH Np/Cholesterol/Megalin 0.001 0.076 0.161 3.0 -0.31 15.0 18.0 SHH -0.005 0.083 -9999.0 0.0 -0.387 14.0 14.0 catabolic process -0.028 0.149 -9999.0 0.0 -0.364 45.0 45.0 SMO/Vitamin D3 -0.04 0.182 -9999.0 0.0 -0.498 32.0 32.0 SHH Np/Cholesterol/Hhip -0.038 0.127 0.161 2.0 -0.319 48.0 50.0 LRP2 -0.006 0.054 -9999.0 0.0 -0.178 25.0 25.0 receptor-mediated endocytosis -0.044 0.173 -9999.0 0.0 -0.539 24.0 24.0 SHH Np/Cholesterol/BOC -0.019 0.105 -9999.0 0.0 -0.31 32.0 32.0 SHH Np/Cholesterol/CDO 0.004 0.079 0.161 1.0 -0.303 19.0 20.0 mesenchymal cell differentiation 0.038 0.126 0.317 48.0 -0.159 2.0 50.0 mol:Vitamin D3 -0.02 0.159 -9999.0 0.0 -0.392 33.0 33.0 IHH N/PTCH2 -0.027 0.153 -9999.0 0.0 -0.416 37.0 37.0 CDON 0.014 0.067 -9999.0 0.0 -0.334 9.0 9.0 IHH N/PTCH1 -0.023 0.153 -9999.0 0.0 -0.367 45.0 45.0 Megalin/LRPAP1 0.021 0.041 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 -0.012 0.126 -9999.0 0.0 -0.379 28.0 28.0 SHH Np/Cholesterol -0.001 0.067 -9999.0 0.0 -0.297 15.0 15.0 PTCH1 -0.029 0.15 -9999.0 0.0 -0.365 45.0 45.0 HHIP -0.064 0.186 -9999.0 0.0 -0.394 65.0 65.0