E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.007 0.143 -9999.0 0.0 -0.492 16.0 16.0 KLHL20 0.031 0.119 0.224 14.0 -0.245 19.0 33.0 CYFIP2 0.012 0.108 -9999.0 0.0 -0.444 11.0 11.0 Rac1/GDP 0.047 0.14 0.289 6.0 -0.36 11.0 17.0 ENAH -0.016 0.15 -9999.0 0.0 -0.504 16.0 16.0 AP1M1 0.035 0.035 -9999.0 0.0 -0.47 1.0 1.0 RAP1B 0.035 0.035 -9999.0 0.0 -0.469 1.0 1.0 RAP1A 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.018 0.081 -9999.0 0.0 -0.274 13.0 13.0 CDC42/GTP 0.047 0.104 -9999.0 0.0 -0.362 6.0 6.0 ABI1/Sra1/Nap1 -0.028 0.058 -9999.0 0.0 -0.176 23.0 23.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.123 -9999.0 0.0 -0.264 28.0 28.0 RAPGEF1 0.036 0.155 0.303 5.0 -0.491 11.0 16.0 CTNND1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.002 0.149 -9999.0 0.0 -0.503 16.0 16.0 CRK 0.032 0.159 -9999.0 0.0 -0.534 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.053 0.079 -9999.0 0.0 -0.288 10.0 10.0 alphaE/beta7 Integrin 0.017 0.097 -9999.0 0.0 -0.334 14.0 14.0 IQGAP1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.064 -9999.0 0.0 -0.244 10.0 10.0 Rap1/GTP/I-afadin 0.056 0.059 -9999.0 0.0 -0.261 6.0 6.0 DLG1 -0.008 0.143 -9999.0 0.0 -0.492 16.0 16.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.055 -9999.0 0.0 -0.268 6.0 6.0 MLLT4 0.024 0.077 -9999.0 0.0 -0.47 5.0 5.0 ARF6/GTP/NME1/Tiam1 0.05 0.059 -9999.0 0.0 -0.272 5.0 5.0 PI3K -0.01 0.074 -9999.0 0.0 -0.357 6.0 6.0 ARF6 0.029 0.05 -9999.0 0.0 -0.469 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.034 0.084 -9999.0 0.0 -0.339 10.0 10.0 TIAM1 0.03 0.051 -9999.0 0.0 -0.375 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.055 0.091 -9999.0 0.0 -0.252 14.0 14.0 AKT1 0.028 0.068 0.183 5.0 -0.203 5.0 10.0 PIK3R1 0.03 0.06 -9999.0 0.0 -0.47 3.0 3.0 CDH1 0.013 0.107 -9999.0 0.0 -0.47 10.0 10.0 RhoA/GDP 0.064 0.146 0.32 7.0 -0.359 11.0 18.0 actin cytoskeleton organization 0.033 0.097 0.206 17.0 -0.179 18.0 35.0 CDC42/GDP 0.06 0.146 0.318 8.0 -0.359 11.0 19.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.055 -9999.0 0.0 -0.228 10.0 10.0 ITGB7 0.004 0.125 -9999.0 0.0 -0.47 14.0 14.0 RAC1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.06 0.097 -9999.0 0.0 -0.268 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.037 0.083 -9999.0 0.0 -0.251 14.0 14.0 mol:GDP 0.049 0.159 0.321 8.0 -0.423 11.0 19.0 CDC42/GTP/IQGAP1 0.043 0.02 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.017 -9999.0 0.0 -0.187 1.0 1.0 p120 catenin/RhoA/GDP 0.072 0.152 0.337 6.0 -0.369 11.0 17.0 RAC1/GTP/IQGAP1 0.042 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.052 0.028 -9999.0 0.0 -0.339 1.0 1.0 RHOA 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.034 0.018 -9999.0 0.0 -0.187 1.0 1.0 CTNNA1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.03 0.077 0.169 20.0 -0.168 5.0 25.0 NME1 0.033 0.036 -9999.0 0.0 -0.469 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.143 -9999.0 0.0 -0.492 16.0 16.0 regulation of cell-cell adhesion -0.002 0.068 -9999.0 0.0 -0.314 6.0 6.0 WASF2 0.012 0.053 0.111 13.0 -0.129 5.0 18.0 Rap1/GTP 0.071 0.127 0.306 4.0 -0.414 6.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.114 -9999.0 0.0 -0.247 23.0 23.0 CCND1 0.033 0.09 0.192 20.0 -0.209 5.0 25.0 VAV2 0.006 0.287 0.416 1.0 -0.72 23.0 24.0 RAP1/GDP 0.073 0.138 0.33 5.0 -0.426 6.0 11.0 adherens junction assembly -0.009 0.138 -9999.0 0.0 -0.475 16.0 16.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.019 0.111 -9999.0 0.0 -0.243 26.0 26.0 E-cadherin/beta catenin -0.002 0.079 -9999.0 0.0 -0.331 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.018 0.138 -9999.0 0.0 -0.57 11.0 11.0 PIK3CA 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.042 0.133 -9999.0 0.0 -0.392 23.0 23.0 E-cadherin/beta catenin/alpha catenin 0.041 0.097 -9999.0 0.0 -0.294 14.0 14.0 ITGAE 0.028 0.026 -9999.0 0.0 -0.187 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.152 -9999.0 0.0 -0.516 16.0 16.0