Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.008 0.156 -9999.0 0.0 -0.661 9.0 9.0 IHH 0.024 0.102 -9999.0 0.0 -0.559 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.072 0.136 -9999.0 0.0 -0.288 50.0 50.0 LRPAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.071 0.135 0.287 50.0 -9999.0 0.0 50.0 SMO/beta Arrestin2 0.001 0.157 -9999.0 0.0 -0.598 8.0 8.0 SMO -0.012 0.156 -9999.0 0.0 -0.6 9.0 9.0 AKT1 -0.016 0.164 -9999.0 0.0 -0.59 9.0 9.0 ARRB2 0.028 0.037 -9999.0 0.0 -0.47 1.0 1.0 BOC 0.029 0.05 -9999.0 0.0 -0.228 7.0 7.0 ADRBK1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.153 -9999.0 0.0 -0.588 9.0 9.0 STIL -0.007 0.129 0.365 1.0 -0.383 11.0 12.0 DHH N/PTCH2 0.054 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.033 0.12 -9999.0 0.0 -0.451 9.0 9.0 PIK3CA 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.006 0.205 -9999.0 0.0 -0.914 9.0 9.0 determination of left/right symmetry -0.011 0.153 -9999.0 0.0 -0.588 9.0 9.0 PIK3R1 0.03 0.06 -9999.0 0.0 -0.47 3.0 3.0 skeletal system development -0.005 0.203 -9999.0 0.0 -0.901 9.0 9.0 IHH N/Hhip -0.014 0.161 -9999.0 0.0 -0.397 29.0 29.0 DHH N/Hhip -0.003 0.131 -9999.0 0.0 -0.339 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.153 -9999.0 0.0 -0.588 9.0 9.0 pancreas development -0.036 0.168 -9999.0 0.0 -0.385 37.0 37.0 HHAT -0.0 0.125 -9999.0 0.0 -0.38 19.0 19.0 PI3K 0.048 0.047 -9999.0 0.0 -0.339 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.114 0.197 -9999.0 0.0 -0.316 92.0 92.0 somite specification -0.011 0.153 -9999.0 0.0 -0.588 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.002 0.122 -9999.0 0.0 -0.419 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.011 0.078 -9999.0 0.0 -0.266 14.0 14.0 SHH Np/Cholesterol/Megalin 0.01 0.079 -9999.0 0.0 -0.266 14.0 14.0 SHH -0.01 0.092 -9999.0 0.0 -0.345 14.0 14.0 catabolic process 0.015 0.125 -9999.0 0.0 -0.441 12.0 12.0 SMO/Vitamin D3 -0.012 0.145 -9999.0 0.0 -0.524 9.0 9.0 SHH Np/Cholesterol/Hhip -0.03 0.127 -9999.0 0.0 -0.296 35.0 35.0 LRP2 0.035 0.022 -9999.0 0.0 -0.187 2.0 2.0 receptor-mediated endocytosis -0.017 0.143 -9999.0 0.0 -0.52 9.0 9.0 SHH Np/Cholesterol/BOC 0.007 0.08 -9999.0 0.0 -0.266 14.0 14.0 SHH Np/Cholesterol/CDO 0.009 0.079 -9999.0 0.0 -0.266 14.0 14.0 mesenchymal cell differentiation 0.03 0.126 0.294 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 0.006 0.132 0.387 1.0 -0.421 9.0 10.0 IHH N/PTCH2 0.045 0.068 -9999.0 0.0 -0.343 5.0 5.0 CDON 0.035 0.022 -9999.0 0.0 -0.187 2.0 2.0 IHH N/PTCH1 0.026 0.129 -9999.0 0.0 -0.445 12.0 12.0 Megalin/LRPAP1 0.052 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.002 0.073 -9999.0 0.0 -0.264 14.0 14.0 PTCH1 0.015 0.126 -9999.0 0.0 -0.443 12.0 12.0 HHIP -0.036 0.168 -9999.0 0.0 -0.386 37.0 37.0