Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.01 0.075 -9999.0 0.0 -0.229 17.0 17.0 epithelial cell differentiation 0.048 0.087 -9999.0 0.0 -0.25 14.0 14.0 CYFIP2 0.012 0.108 -9999.0 0.0 -0.444 11.0 11.0 ENAH -0.039 0.083 0.277 1.0 -0.347 5.0 6.0 EGFR 0.018 0.086 -9999.0 0.0 -0.399 8.0 8.0 EPHA2 0.014 0.083 -9999.0 0.0 -0.263 15.0 15.0 MYO6 -0.007 0.075 -9999.0 0.0 -0.242 17.0 17.0 CTNNB1 0.018 0.081 -9999.0 0.0 -0.274 13.0 13.0 ABI1/Sra1/Nap1 0.048 0.089 -9999.0 0.0 -0.296 11.0 11.0 AQP5 -0.005 0.094 -9999.0 0.0 -0.489 4.0 4.0 CTNND1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.07 -9999.0 0.0 -0.238 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.096 -9999.0 0.0 -0.24 32.0 32.0 EGF -0.087 0.183 -9999.0 0.0 -0.303 78.0 78.0 NCKAP1 0.025 0.064 -9999.0 0.0 -0.244 10.0 10.0 AQP3 -0.019 0.111 -9999.0 0.0 -0.454 8.0 8.0 cortical microtubule organization 0.048 0.087 -9999.0 0.0 -0.25 14.0 14.0 GO:0000145 -0.024 0.061 0.165 4.0 -0.228 14.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.055 0.091 -9999.0 0.0 -0.252 14.0 14.0 MLLT4 0.024 0.077 -9999.0 0.0 -0.47 5.0 5.0 ARF6/GDP -0.051 0.085 -9999.0 0.0 -0.356 8.0 8.0 ARF6 0.029 0.05 -9999.0 0.0 -0.47 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.049 0.098 -9999.0 0.0 -0.277 12.0 12.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.072 -9999.0 0.0 -0.277 6.0 6.0 PVRL2 0.032 0.041 -9999.0 0.0 -0.281 3.0 3.0 ZYX -0.006 0.071 -9999.0 0.0 -0.241 16.0 16.0 ARF6/GTP 0.047 0.103 -9999.0 0.0 -0.266 14.0 14.0 CDH1 0.013 0.107 -9999.0 0.0 -0.47 10.0 10.0 EGFR/EGFR/EGF/EGF -0.035 0.134 -9999.0 0.0 -0.262 44.0 44.0 RhoA/GDP 0.051 0.086 -9999.0 0.0 -0.24 14.0 14.0 actin cytoskeleton organization -0.03 0.064 -9999.0 0.0 -0.24 13.0 13.0 IGF-1R heterotetramer 0.032 0.039 -9999.0 0.0 -0.328 2.0 2.0 GIT1 0.035 0.017 -9999.0 0.0 -0.187 1.0 1.0 IGF1R 0.032 0.039 -9999.0 0.0 -0.328 2.0 2.0 IGF1 0.018 0.078 -9999.0 0.0 -0.244 15.0 15.0 DIAPH1 0.029 0.18 -9999.0 0.0 -0.628 13.0 13.0 Wnt receptor signaling pathway -0.048 0.087 0.25 14.0 -9999.0 0.0 14.0 RHOA 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.082 -9999.0 0.0 -0.387 6.0 6.0 CTNNA1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.031 0.066 -9999.0 0.0 -0.245 13.0 13.0 EFNA1 0.023 0.075 -9999.0 0.0 -0.328 8.0 8.0 LPP -0.025 0.062 0.172 4.0 -0.235 13.0 17.0 Ephrin A1/EPHA2 0.02 0.113 -9999.0 0.0 -0.29 19.0 19.0 SEC6/SEC8 -0.008 0.085 -9999.0 0.0 -0.285 16.0 16.0 MGAT3 -0.035 0.097 -9999.0 0.0 -0.243 32.0 32.0 HGF/MET 0.036 0.092 -9999.0 0.0 -0.255 15.0 15.0 HGF 0.034 0.023 -9999.0 0.0 -0.187 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.075 -9999.0 0.0 -0.231 17.0 17.0 actin cable formation -0.018 0.102 0.356 4.0 -0.289 9.0 13.0 KIAA1543 -0.025 0.061 -9999.0 0.0 -0.232 13.0 13.0 KIFC3 -0.006 0.071 -9999.0 0.0 -0.242 15.0 15.0 NCK1 0.028 0.069 -9999.0 0.0 -0.47 4.0 4.0 EXOC3 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.002 0.07 -9999.0 0.0 -0.242 14.0 14.0 NCK1/GIT1 0.044 0.056 -9999.0 0.0 -0.339 4.0 4.0 mol:GDP 0.048 0.087 -9999.0 0.0 -0.25 14.0 14.0 EXOC4 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.004 0.069 -9999.0 0.0 -0.242 15.0 15.0 PIP5K1C -0.001 0.071 -9999.0 0.0 -0.242 14.0 14.0 LIMA1 0.026 0.072 -9999.0 0.0 -0.375 6.0 6.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.031 0.091 0.299 3.0 -0.387 4.0 7.0 adherens junction assembly -0.007 0.073 0.27 3.0 -0.315 1.0 4.0 IGF-1R heterotetramer/IGF1 0.026 0.095 -9999.0 0.0 -0.243 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.068 -9999.0 0.0 -0.339 6.0 6.0 MET 0.029 0.054 -9999.0 0.0 -0.328 4.0 4.0 PLEKHA7 -0.0 0.071 -9999.0 0.0 -0.241 14.0 14.0 mol:GTP 0.046 0.096 -9999.0 0.0 -0.275 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.025 0.095 0.328 1.0 -0.368 6.0 7.0 cortical actin cytoskeleton stabilization 0.01 0.075 -9999.0 0.0 -0.229 17.0 17.0 regulation of cell-cell adhesion -0.03 0.064 -9999.0 0.0 -0.24 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.075 -9999.0 0.0 -0.231 17.0 17.0