Clinical Features MRNA_CNMF MRNA_CHIERARCHICAL MIR_CNMF MIR_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q EGFR 74 (26%) 209 0.0070287 0.815 0.030918 1 0.36931 1 0.18378 1 8.2271e-07 0.000114 0.005644 0.672 6.3736e-05 0.0086 1.463e-06 2e-04 0.041343 1 0.35695 1 PIK3R1 32 (11%) 251 0.75107 1 0.68132 1 0.44535 1 0.31357 1 0.11484 1 0.40691 1 0.98818 1 0.27286 1 0.40561 1 0.64893 1 BRAF 6 (2%) 277 0.76786 1 0.35249 1 0.61931 1 0.091901 1 0.58533 1 NA NA 1 1 0.078076 1 0.79121 1 1 1 IDH1 14 (5%) 269 9.1274e-05 0.0121 8.1979e-07 0.000114 0.00023712 0.0311 3.9046e-05 0.00531 7.6126e-05 0.0102 0.001511 0.189 0.0035226 0.423 0.020325 1 0.00071234 0.0912 0.0026329 0.319 TP53 79 (28%) 204 0.00066112 0.0853 0.000459 0.0597 0.0013944 0.176 0.024959 1 0.00012164 0.0161 0.0083687 0.962 0.038377 1 0.0096772 1 0.0018446 0.227 0.037471 1 PTEN 87 (31%) 196 0.11598 1 0.42583 1 0.046075 1 0.85855 1 0.59921 1 0.91703 1 0.37848 1 0.38945 1 0.27044 1 0.19564 1 PIK3CA 30 (11%) 253 0.72519 1 0.63051 1 0.53689 1 0.64916 1 0.49989 1 0.91635 1 0.7545 1 0.28115 1 0.26203 1 0.83762 1 RB1 25 (9%) 258 0.014957 1 0.0064802 0.765 0.055799 1 0.34304 1 0.06501 1 0.070948 1 0.4926 1 0.69117 1 0.043424 1 0.040654 1 PRB2 6 (2%) 277 0.64162 1 0.37267 1 0.47781 1 0.6241 1 0.77118 1 NA NA NA NA NA NA NA NA NA NA NF1 29 (10%) 254 0.081103 1 0.053291 1 0.086605 1 0.42291 1 0.0012254 0.156 0.0016722 0.207 0.22964 1 0.11973 1 0.56596 1 0.91494 1 STAG2 12 (4%) 271 0.39164 1 0.13238 1 0.30589 1 0.019445 1 0.75649 1 0.75207 1 0.0069359 0.812 0.18373 1 0.47875 1 0.77076 1 CDC27 6 (2%) 277 0.35053 1 0.37267 1 0.75706 1 0.37282 1 0.44819 1 0.22659 1 0.27836 1 0.32478 1 NA NA NA NA WNT2 5 (2%) 278 0.15125 1 0.0023459 0.286 1 1 0.7843 1 1 1 NA NA 0.041607 1 0.42317 1 NA NA NA NA TPTE2 8 (3%) 275 0.46042 1 1 1 0.35978 1 0.24368 1 0.30554 1 0.43781 1 0.62449 1 0.4088 1 0.37597 1 0.74053 1 GABRA6 11 (4%) 272 0.11096 1 0.56039 1 0.51033 1 0.55452 1 0.36527 1 0.66978 1 0.31791 1 0.47355 1 0.12381 1 1 1