E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.162 -9999.0 0.0 -0.397 25.0 25.0 KLHL20 0.021 0.099 0.179 12.0 -0.223 4.0 16.0 CYFIP2 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.019 0.103 -9999.0 0.0 -0.261 19.0 19.0 ENAH -0.045 0.159 -9999.0 0.0 -0.39 25.0 25.0 AP1M1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.006 0.084 -9999.0 0.0 -0.192 20.0 20.0 ABI1/Sra1/Nap1 -0.02 0.044 -9999.0 0.0 -0.153 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.026 0.114 -9999.0 0.0 -0.227 24.0 24.0 RAPGEF1 -0.041 0.15 -9999.0 0.0 -0.378 21.0 21.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.169 -9999.0 0.0 -0.404 25.0 25.0 CRK -0.044 0.155 -9999.0 0.0 -0.377 24.0 24.0 E-cadherin/gamma catenin/alpha catenin 0.008 0.116 -9999.0 0.0 -0.246 24.0 24.0 alphaE/beta7 Integrin 0.041 0.041 -9999.0 0.0 -0.277 2.0 2.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.052 0.025 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.048 0.162 -9999.0 0.0 -0.397 25.0 25.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.047 -9999.0 0.0 -0.147 20.0 20.0 MLLT4 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.057 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.043 0.061 -9999.0 0.0 -0.187 20.0 20.0 ARF6 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.013 0.124 -9999.0 0.0 -0.289 24.0 24.0 TIAM1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.028 0.105 -9999.0 0.0 -0.211 23.0 23.0 AKT1 -0.017 0.053 0.15 1.0 -0.169 1.0 2.0 PIK3R1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.041 0.157 -9999.0 0.0 -0.402 23.0 23.0 RhoA/GDP -0.014 0.117 -9999.0 0.0 -0.26 21.0 21.0 actin cytoskeleton organization 0.019 0.077 0.148 12.0 -0.162 4.0 16.0 CDC42/GDP -0.014 0.117 -9999.0 0.0 -0.26 21.0 21.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.02 0.088 -9999.0 0.0 -0.212 25.0 25.0 ITGB7 0.026 0.051 -9999.0 0.0 -0.402 2.0 2.0 RAC1 0.022 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.03 0.112 -9999.0 0.0 -0.225 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.009 0.096 -9999.0 0.0 -0.207 23.0 23.0 mol:GDP -0.031 0.124 -9999.0 0.0 -0.295 21.0 21.0 CDC42/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.029 0.037 -9999.0 0.0 -0.402 1.0 1.0 p120 catenin/RhoA/GDP -0.003 0.124 -9999.0 0.0 -0.267 21.0 21.0 RAC1/GTP/IQGAP1 0.03 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.03 -9999.0 0.0 -0.287 1.0 1.0 RHOA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.054 0.112 11.0 -0.12 2.0 13.0 NME1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.046 0.161 -9999.0 0.0 -0.402 24.0 24.0 regulation of cell-cell adhesion -0.015 0.067 -9999.0 0.0 -0.171 20.0 20.0 WASF2 0.008 0.042 0.094 5.0 -0.097 2.0 7.0 Rap1/GTP -0.006 0.094 0.169 7.0 -0.21 20.0 27.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.037 0.118 -9999.0 0.0 -0.217 25.0 25.0 CCND1 0.017 0.063 0.128 11.0 -0.145 2.0 13.0 VAV2 -0.051 0.214 -9999.0 0.0 -0.462 27.0 27.0 RAP1/GDP -0.003 0.103 -9999.0 0.0 -0.221 21.0 21.0 adherens junction assembly -0.044 0.156 -9999.0 0.0 -0.39 24.0 24.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.036 -9999.0 0.0 -0.402 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.012 0.106 -9999.0 0.0 -0.212 25.0 25.0 E-cadherin/beta catenin -0.044 0.114 -9999.0 0.0 -0.304 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.047 0.158 -9999.0 0.0 -0.395 24.0 24.0 PIK3CA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.034 0.1 -9999.0 0.0 -0.296 8.0 8.0 E-cadherin/beta catenin/alpha catenin 0.009 0.113 -9999.0 0.0 -0.245 23.0 23.0 ITGAE 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.172 -9999.0 0.0 -0.412 25.0 25.0