Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.004 0.128 -9999.0 0.0 -0.488 9.0 9.0 IHH 0.021 0.051 -9999.0 0.0 -0.168 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.012 0.075 -9999.0 0.0 -0.238 13.0 13.0 LRPAP1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.012 0.075 0.236 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.045 0.117 -9999.0 0.0 -0.524 3.0 3.0 SMO -0.004 0.093 -9999.0 0.0 -0.483 4.0 4.0 AKT1 -0.004 0.102 -9999.0 0.0 -0.41 5.0 5.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.028 0.038 -9999.0 0.0 -0.402 1.0 1.0 ADRBK1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 STIL 0.014 0.121 0.18 29.0 -0.316 7.0 36.0 DHH N/PTCH2 0.022 0.079 -9999.0 0.0 -0.29 8.0 8.0 DHH N/PTCH1 0.009 0.107 -9999.0 0.0 -0.322 12.0 12.0 PIK3CA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.014 0.073 -9999.0 0.0 -0.402 4.0 4.0 PTHLH -0.014 0.155 -9999.0 0.0 -0.611 8.0 8.0 determination of left/right symmetry -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 PIK3R1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.014 0.153 -9999.0 0.0 -0.606 8.0 8.0 IHH N/Hhip -0.015 0.125 -9999.0 0.0 -0.328 18.0 18.0 DHH N/Hhip -0.014 0.12 -9999.0 0.0 -0.3 20.0 20.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 pancreas development -0.032 0.141 -9999.0 0.0 -0.402 18.0 18.0 HHAT 0.026 0.051 -9999.0 0.0 -0.402 2.0 2.0 PI3K 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.012 0.074 -9999.0 0.0 -0.402 4.0 4.0 somite specification -0.004 0.091 -9999.0 0.0 -0.476 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.018 0.091 -9999.0 0.0 -0.254 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.007 0.071 -9999.0 0.0 -0.239 11.0 11.0 SHH Np/Cholesterol/Megalin -0.038 0.103 -9999.0 0.0 -0.248 26.0 26.0 SHH -0.032 0.07 -9999.0 0.0 -0.288 10.0 10.0 catabolic process 0.001 0.1 -9999.0 0.0 -0.369 9.0 9.0 SMO/Vitamin D3 -0.014 0.105 -9999.0 0.0 -0.472 4.0 4.0 SHH Np/Cholesterol/Hhip -0.025 0.083 -9999.0 0.0 -0.226 20.0 20.0 LRP2 -0.073 0.176 -9999.0 0.0 -0.402 32.0 32.0 receptor-mediated endocytosis -0.04 0.128 -9999.0 0.0 -0.457 8.0 8.0 SHH Np/Cholesterol/BOC -0.004 0.062 -9999.0 0.0 -0.221 10.0 10.0 SHH Np/Cholesterol/CDO -0.006 0.065 -9999.0 0.0 -0.221 11.0 11.0 mesenchymal cell differentiation 0.025 0.082 0.225 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.028 0.131 0.196 31.0 -0.328 7.0 38.0 IHH N/PTCH2 0.029 0.07 -9999.0 0.0 -0.332 4.0 4.0 CDON 0.023 0.062 -9999.0 0.0 -0.402 3.0 3.0 IHH N/PTCH1 0.01 0.104 -9999.0 0.0 -0.371 9.0 9.0 Megalin/LRPAP1 -0.035 0.136 -9999.0 0.0 -0.287 32.0 32.0 PTCH2 0.02 0.071 -9999.0 0.0 -0.402 4.0 4.0 SHH Np/Cholesterol -0.009 0.058 -9999.0 0.0 -0.217 10.0 10.0 PTCH1 0.001 0.101 -9999.0 0.0 -0.37 9.0 9.0 HHIP -0.032 0.142 -9999.0 0.0 -0.402 18.0 18.0