E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.007 0.053 -9999.0 0.0 -0.295 14.0 14.0 KLHL20 0.028 0.068 0.172 34.0 -0.178 15.0 49.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.006 0.039 0.168 9.0 -0.163 9.0 18.0 ENAH 0.005 0.055 -9999.0 0.0 -0.295 15.0 15.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.033 0.111 20.0 -0.117 9.0 29.0 ABI1/Sra1/Nap1 -0.01 0.022 -9999.0 0.0 -0.117 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.072 0.035 -9999.0 0.0 -0.053 10.0 10.0 RAPGEF1 -0.002 0.06 0.163 31.0 -0.275 11.0 42.0 CTNND1 0.03 0.014 -9999.0 0.0 -0.065 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.056 -9999.0 0.0 -0.296 14.0 14.0 CRK 0.005 0.061 0.173 25.0 -0.286 13.0 38.0 E-cadherin/gamma catenin/alpha catenin 0.059 0.026 -9999.0 0.0 -0.055 20.0 20.0 alphaE/beta7 Integrin 0.046 0.012 -9999.0 0.0 -0.051 2.0 2.0 IQGAP1 0.009 0.041 -9999.0 0.0 -0.065 120.0 120.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.018 -9999.0 0.0 -0.023 40.0 40.0 DLG1 0.006 0.055 -9999.0 0.0 -0.294 15.0 15.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.018 -9999.0 0.0 -0.093 12.0 12.0 MLLT4 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.017 -9999.0 0.0 -0.023 29.0 29.0 PI3K -0.036 0.022 -9999.0 0.0 -0.116 12.0 12.0 ARF6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.043 0.022 -9999.0 0.0 -0.058 19.0 19.0 TIAM1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.066 0.034 -9999.0 0.0 -0.048 9.0 9.0 AKT1 -0.016 0.037 0.14 9.0 -0.1 2.0 11.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.03 0.013 -9999.0 0.0 -0.065 8.0 8.0 RhoA/GDP 0.012 0.06 0.175 27.0 -0.17 16.0 43.0 actin cytoskeleton organization 0.024 0.054 0.14 35.0 -0.131 15.0 50.0 CDC42/GDP 0.011 0.057 0.175 23.0 -0.168 16.0 39.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.027 -9999.0 0.0 -0.108 19.0 19.0 ITGB7 0.031 0.008 -9999.0 0.0 -0.065 2.0 2.0 RAC1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.072 0.036 -9999.0 0.0 -0.051 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.052 0.022 -9999.0 0.0 -0.032 28.0 28.0 mol:GDP -0.002 0.061 0.175 26.0 -0.184 16.0 42.0 CDC42/GTP/IQGAP1 0.022 0.036 -9999.0 0.0 -0.041 119.0 119.0 JUP 0.029 0.017 -9999.0 0.0 -0.065 16.0 16.0 p120 catenin/RhoA/GDP 0.025 0.063 0.186 26.0 -0.171 18.0 44.0 RAC1/GTP/IQGAP1 0.016 0.032 -9999.0 0.0 -0.04 89.0 89.0 PIP5K1C/AP1M1 0.022 0.006 -9999.0 0.0 0.0 37.0 37.0 RHOA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.04 0.107 30.0 -0.094 14.0 44.0 NME1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.006 0.055 -9999.0 0.0 -0.295 15.0 15.0 regulation of cell-cell adhesion -0.029 0.017 0.043 1.0 -0.099 13.0 14.0 WASF2 -0.006 0.012 -9999.0 0.0 -0.064 15.0 15.0 Rap1/GTP -0.022 0.045 0.144 29.0 -0.141 4.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.082 0.043 -9999.0 0.0 -0.076 5.0 5.0 CCND1 0.017 0.047 0.123 30.0 -0.114 14.0 44.0 VAV2 0.014 0.113 -9999.0 0.0 -0.577 13.0 13.0 RAP1/GDP -0.011 0.052 0.163 31.0 -0.174 3.0 34.0 adherens junction assembly 0.006 0.053 -9999.0 0.0 -0.287 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.008 -9999.0 0.0 0.0 37.0 37.0 regulation of heterotypic cell-cell adhesion 0.054 0.038 0.189 2.0 -0.082 3.0 5.0 E-cadherin/beta catenin 0.005 0.022 -9999.0 0.0 -0.127 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.005 0.053 -9999.0 0.0 -0.295 14.0 14.0 PIK3CA 0.028 0.018 -9999.0 0.0 -0.065 17.0 17.0 Rac1/GTP -0.007 0.055 -9999.0 0.0 -0.264 16.0 16.0 E-cadherin/beta catenin/alpha catenin 0.06 0.021 -9999.0 0.0 -0.05 9.0 9.0 ITGAE 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.057 -9999.0 0.0 -0.302 14.0 14.0