Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.017 0.184 -9999.0 0.0 -0.656 2.0 2.0 IHH -0.1 0.311 -9999.0 0.0 -0.888 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.025 0.111 -9999.0 0.0 -0.545 6.0 6.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.025 0.11 0.541 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.019 0.2 -9999.0 0.0 -0.514 19.0 19.0 SMO -0.027 0.211 -9999.0 0.0 -0.547 19.0 19.0 AKT1 0.013 0.094 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.026 0.208 -9999.0 0.0 -0.538 19.0 19.0 STIL -0.014 0.166 -9999.0 0.0 -0.5 6.0 6.0 DHH N/PTCH2 -0.035 0.148 -9999.0 0.0 -0.676 7.0 7.0 DHH N/PTCH1 -0.054 0.217 -9999.0 0.0 -0.508 25.0 25.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.033 0.192 -9999.0 0.0 -0.871 7.0 7.0 PTHLH -0.027 0.214 -9999.0 0.0 -0.838 2.0 2.0 determination of left/right symmetry -0.026 0.208 -9999.0 0.0 -0.538 19.0 19.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.026 0.212 -9999.0 0.0 -0.828 2.0 2.0 IHH N/Hhip -0.1 0.259 -9999.0 0.0 -0.639 26.0 26.0 DHH N/Hhip -0.068 0.223 -9999.0 0.0 -0.768 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.026 0.208 -9999.0 0.0 -0.538 19.0 19.0 pancreas development -0.037 0.195 -9999.0 0.0 -0.751 9.0 9.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.019 0.163 -9999.0 0.0 -0.871 5.0 5.0 somite specification -0.026 0.208 -9999.0 0.0 -0.538 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.019 0.167 -9999.0 0.0 -0.519 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.007 0.051 -9999.0 0.0 -0.545 1.0 1.0 SHH Np/Cholesterol/Megalin -0.072 0.185 -9999.0 0.0 -0.554 18.0 18.0 SHH 0.014 0.065 -9999.0 0.0 -0.678 1.0 1.0 catabolic process -0.032 0.198 -9999.0 0.0 -0.529 19.0 19.0 SMO/Vitamin D3 -0.02 0.188 -9999.0 0.0 -0.583 5.0 5.0 SHH Np/Cholesterol/Hhip -0.036 0.13 -9999.0 0.0 -0.546 8.0 8.0 LRP2 -0.094 0.288 -9999.0 0.0 -0.871 17.0 17.0 receptor-mediated endocytosis -0.103 0.224 -9999.0 0.0 -0.741 11.0 11.0 SHH Np/Cholesterol/BOC -0.006 0.049 -9999.0 0.0 -0.545 1.0 1.0 SHH Np/Cholesterol/CDO -0.01 0.055 -9999.0 0.0 -0.545 1.0 1.0 mesenchymal cell differentiation 0.035 0.128 0.542 8.0 -9999.0 0.0 8.0 mol:Vitamin D3 -0.016 0.171 -9999.0 0.0 -0.523 4.0 4.0 IHH N/PTCH2 -0.061 0.212 -9999.0 0.0 -0.596 19.0 19.0 CDON 0.002 0.058 -9999.0 0.0 -0.338 4.0 4.0 IHH N/PTCH1 -0.033 0.2 -9999.0 0.0 -0.536 19.0 19.0 Megalin/LRPAP1 -0.082 0.22 -9999.0 0.0 -0.676 17.0 17.0 PTCH2 0.01 0.029 -9999.0 0.0 -0.338 1.0 1.0 SHH Np/Cholesterol -0.006 0.05 -9999.0 0.0 -0.553 1.0 1.0 PTCH1 -0.032 0.199 -9999.0 0.0 -0.531 19.0 19.0 HHIP -0.037 0.195 -9999.0 0.0 -0.753 9.0 9.0