Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.007 0.113 -9999.0 0.0 -0.348 14.0 14.0 epithelial cell differentiation -0.05 0.151 -9999.0 0.0 -0.505 14.0 14.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.029 0.107 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.01 0.029 -9999.0 0.0 -0.338 1.0 1.0 MYO6 -0.014 0.155 -9999.0 0.0 -0.48 14.0 14.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.106 0.228 -9999.0 0.0 -0.662 15.0 15.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.152 -9999.0 0.0 -0.472 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.053 0.21 -9999.0 0.0 -0.515 23.0 23.0 EGF -0.765 0.287 -9999.0 0.0 -0.871 124.0 124.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.26 0.334 -9999.0 0.0 -0.678 51.0 51.0 cortical microtubule organization -0.05 0.151 -9999.0 0.0 -0.505 14.0 14.0 GO:0000145 -0.012 0.145 -9999.0 0.0 -0.45 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.051 0.153 -9999.0 0.0 -0.512 14.0 14.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.04 0.118 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.0 0.146 -9999.0 0.0 -0.441 14.0 14.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.014 0.155 -9999.0 0.0 -0.48 14.0 14.0 ARF6/GTP -0.001 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.075 0.264 -9999.0 0.0 -0.871 14.0 14.0 EGFR/EGFR/EGF/EGF -0.456 0.21 -9999.0 0.0 -0.514 125.0 125.0 RhoA/GDP -0.047 0.142 -9999.0 0.0 -0.474 14.0 14.0 actin cytoskeleton organization -0.006 0.148 -9999.0 0.0 -0.452 14.0 14.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.013 0.147 -9999.0 0.0 -0.871 4.0 4.0 DIAPH1 -0.003 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.05 0.151 0.505 14.0 -9999.0 0.0 14.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.04 0.12 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.007 0.152 -9999.0 0.0 -0.464 14.0 14.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.005 0.148 -9999.0 0.0 -0.451 14.0 14.0 Ephrin A1/EPHA2 -0.046 0.138 -9999.0 0.0 -0.46 14.0 14.0 SEC6/SEC8 -0.042 0.126 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.055 0.215 -9999.0 0.0 -0.526 23.0 23.0 HGF/MET -0.084 0.178 -9999.0 0.0 -0.5 20.0 20.0 HGF -0.032 0.192 -9999.0 0.0 -0.871 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.008 0.114 -9999.0 0.0 -0.351 14.0 14.0 actin cable formation 0.046 0.103 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.005 0.148 -9999.0 0.0 -0.451 14.0 14.0 KIFC3 -0.014 0.155 -9999.0 0.0 -0.48 14.0 14.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.155 -9999.0 0.0 -0.48 14.0 14.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.05 0.151 -9999.0 0.0 -0.505 14.0 14.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.014 0.155 -9999.0 0.0 -0.48 14.0 14.0 PIP5K1C -0.014 0.155 -9999.0 0.0 -0.48 14.0 14.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.035 0.104 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.013 0.14 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.059 0.154 -9999.0 0.0 -0.461 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.033 0.117 -9999.0 0.0 -0.338 18.0 18.0 PLEKHA7 -0.014 0.155 -9999.0 0.0 -0.48 14.0 14.0 mol:GTP -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.015 0.138 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.007 0.113 -9999.0 0.0 -0.348 14.0 14.0 regulation of cell-cell adhesion -0.006 0.148 -9999.0 0.0 -0.452 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.008 0.114 -9999.0 0.0 -0.351 14.0 14.0