Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	65.0	2220.0	34.0	-0.666	0.012	1000.0	-1000.0	-0.07	-1000.0
EGFR-dependent Endothelin signaling events	53.0	1128.0	21.0	-0.765	0.012	1000.0	-1000.0	-0.077	-1000.0
Angiopoietin receptor Tie2-mediated signaling	39.0	3512.0	88.0	-0.909	0.072	1000.0	-1000.0	-0.123	-1000.0
FOXA2 and FOXA3 transcription factor networks	38.0	1773.0	46.0	-1.294	0.019	1000.0	-1000.0	-0.081	-1000.0
Glypican 2 network	32.0	129.0	4.0	-0.135	-1000.0	1000.0	-1000.0	-0.04	-1000.0
PDGFR-alpha signaling pathway	28.0	1245.0	44.0	-0.342	0.028	1000.0	-1000.0	-0.061	-1000.0
Thromboxane A2 receptor signaling	22.0	2312.0	105.0	-0.765	0.08	1000.0	-1000.0	-0.077	-1000.0
Glypican 1 network	21.0	1046.0	48.0	-0.48	0.033	1000.0	-1000.0	-0.059	-1000.0
Arf6 signaling events	19.0	1204.0	62.0	-0.765	0.016	1000.0	-1000.0	-0.07	-1000.0
BMP receptor signaling	16.0	1316.0	81.0	-0.55	0.012	1000.0	-1000.0	-0.094	-1000.0
amb2 Integrin signaling	16.0	1386.0	82.0	-0.568	0.012	1000.0	-1000.0	-0.092	-1000.0
FOXM1 transcription factor network	16.0	826.0	51.0	-0.301	0.022	1000.0	-1000.0	-0.19	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	16.0	1249.0	78.0	-0.332	0.057	1000.0	-1000.0	-0.076	-1000.0
IL4-mediated signaling events	14.0	1342.0	91.0	-0.925	0.495	1000.0	-1000.0	-0.149	-1000.0
TCGA08_retinoblastoma	14.0	112.0	8.0	-0.263	0.069	1000.0	-1000.0	-0.027	-1000.0
Endothelins	13.0	1316.0	96.0	-0.587	0.014	1000.0	-1000.0	-0.09	-1000.0
Syndecan-4-mediated signaling events	13.0	894.0	67.0	-0.54	0.087	1000.0	-1000.0	-0.101	-1000.0
Effects of Botulinum toxin	12.0	330.0	26.0	-0.264	0.015	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	12.0	1606.0	125.0	-0.154	0.014	1000.0	-1000.0	-0.106	-1000.0
Signaling events mediated by PTP1B	11.0	871.0	76.0	-0.769	0.101	1000.0	-1000.0	-0.089	-1000.0
Signaling mediated by p38-alpha and p38-beta	11.0	514.0	44.0	-0.14	0.012	1000.0	-1000.0	-0.055	-1000.0
Integrins in angiogenesis	11.0	957.0	84.0	-0.597	0.034	1000.0	-1000.0	-0.097	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	11.0	779.0	68.0	-0.626	0.069	1000.0	-1000.0	-0.143	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	11.0	1365.0	120.0	-0.364	0.168	1000.0	-1000.0	-0.083	-1000.0
S1P1 pathway	10.0	361.0	36.0	-0.142	0.012	1000.0	-1000.0	-0.061	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	965.0	93.0	-0.608	0.277	1000.0	-1000.0	-0.093	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	807.0	74.0	-0.765	0.05	1000.0	-1000.0	-0.1	-1000.0
Aurora C signaling	9.0	67.0	7.0	-0.154	0.012	1000.0	-1000.0	-0.047	-1000.0
Aurora B signaling	9.0	651.0	67.0	-0.281	0.012	1000.0	-1000.0	-0.081	-1000.0
Syndecan-1-mediated signaling events	8.0	304.0	34.0	-0.123	0.012	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by the Hedgehog family	8.0	435.0	52.0	-0.103	0.035	1000.0	-1000.0	-0.086	-1000.0
Noncanonical Wnt signaling pathway	8.0	213.0	26.0	-0.247	0.012	1000.0	-1000.0	-0.096	-1000.0
FoxO family signaling	8.0	565.0	64.0	-0.967	0.081	1000.0	-1000.0	-0.086	-1000.0
E-cadherin signaling events	8.0	42.0	5.0	-0.075	0.012	1000.0	-1000.0	-0.046	-1000.0
p75(NTR)-mediated signaling	7.0	971.0	125.0	-0.549	0.025	1000.0	-1000.0	-0.102	-1000.0
Wnt signaling	7.0	52.0	7.0	-0.048	0.012	1000.0	-1000.0	-0.036	-1000.0
LPA4-mediated signaling events	6.0	79.0	12.0	-0.217	0.019	1000.0	-1000.0	-0.036	-1000.0
ErbB4 signaling events	6.0	416.0	69.0	-0.376	0.119	1000.0	-1000.0	-0.087	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	172.0	28.0	-0.151	0.012	1000.0	-1000.0	-0.057	-1000.0
HIF-1-alpha transcription factor network	6.0	513.0	76.0	-0.182	0.048	1000.0	-1000.0	-0.166	-1000.0
Glucocorticoid receptor regulatory network	6.0	765.0	114.0	-0.624	0.16	1000.0	-1000.0	-0.078	-1000.0
Ceramide signaling pathway	6.0	511.0	76.0	-0.765	0.253	1000.0	-1000.0	-0.071	-1000.0
Nongenotropic Androgen signaling	6.0	328.0	52.0	-0.099	0.025	1000.0	-1000.0	-0.066	-1000.0
IL27-mediated signaling events	6.0	348.0	51.0	-1.017	0.173	1000.0	-1000.0	-0.091	-1000.0
Plasma membrane estrogen receptor signaling	6.0	564.0	86.0	-0.151	0.028	1000.0	-1000.0	-0.084	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	700.0	136.0	-0.625	0.076	1000.0	-1000.0	-0.076	-1000.0
Coregulation of Androgen receptor activity	5.0	395.0	76.0	-0.814	0.023	1000.0	-1000.0	-0.051	-1000.0
IL12-mediated signaling events	5.0	446.0	87.0	-0.202	0.031	1000.0	-1000.0	-0.136	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	286.0	54.0	-0.256	0.026	1000.0	-1000.0	-0.104	-1000.0
Ephrin A  reverse signaling	5.0	38.0	7.0	-0.036	-0.0	1000.0	-1000.0	-0.037	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	333.0	61.0	-0.215	0.097	1000.0	-1000.0	-0.073	-1000.0
Reelin signaling pathway	5.0	304.0	56.0	-0.194	0.012	1000.0	-1000.0	-0.088	-1000.0
IL6-mediated signaling events	5.0	435.0	75.0	-0.263	0.056	1000.0	-1000.0	-0.093	-1000.0
Regulation of Telomerase	5.0	528.0	102.0	-0.765	0.043	1000.0	-1000.0	-0.109	-1000.0
Visual signal transduction: Rods	5.0	296.0	52.0	-0.227	0.012	1000.0	-1000.0	-0.087	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.008	-1000.0	1000.0	-1000.0	-0.013	-1000.0
Regulation of Androgen receptor activity	5.0	389.0	70.0	-0.912	0.029	1000.0	-1000.0	-0.061	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	-0.018	0.007	1000.0	-1000.0	-0.017	-1000.0
Osteopontin-mediated events	4.0	154.0	38.0	-0.138	0.037	1000.0	-1000.0	-0.108	-1000.0
Syndecan-2-mediated signaling events	4.0	325.0	69.0	-0.568	0.042	1000.0	-1000.0	-0.058	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	390.0	82.0	-0.112	0.012	1000.0	-1000.0	-0.092	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	243.0	52.0	-0.37	0.057	1000.0	-1000.0	-0.067	-1000.0
Syndecan-3-mediated signaling events	4.0	156.0	35.0	-0.187	0.012	1000.0	-1000.0	-0.068	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	150.0	31.0	-0.165	0.016	1000.0	-1000.0	-0.1	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	340.0	76.0	-0.075	0.027	1000.0	-1000.0	-0.092	-1000.0
BCR signaling pathway	4.0	404.0	99.0	-0.103	0.028	1000.0	-1000.0	-0.102	-1000.0
S1P3 pathway	4.0	202.0	42.0	-0.151	0.02	1000.0	-1000.0	-0.059	-1000.0
PDGFR-beta signaling pathway	4.0	394.0	97.0	-0.134	0.045	1000.0	-1000.0	-0.093	-1000.0
E-cadherin signaling in keratinocytes	4.0	180.0	43.0	-0.304	0.033	1000.0	-1000.0	-0.07	-1000.0
Caspase cascade in apoptosis	3.0	270.0	74.0	-0.404	0.038	1000.0	-1000.0	-0.056	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	52.0	17.0	-0.043	0.028	1000.0	-1000.0	-0.076	-1000.0
PLK1 signaling events	3.0	283.0	85.0	-0.127	0.017	1000.0	-1000.0	-0.062	-1000.0
Insulin-mediated glucose transport	3.0	103.0	32.0	-0.139	0.066	1000.0	-1000.0	-0.065	-1000.0
IL1-mediated signaling events	3.0	201.0	62.0	-0.178	0.06	1000.0	-1000.0	-0.106	-1000.0
EPHB forward signaling	3.0	277.0	85.0	-0.157	0.055	1000.0	-1000.0	-0.098	-1000.0
TCGA08_rtk_signaling	3.0	79.0	26.0	-0.276	0.029	1000.0	-1000.0	-0.024	-1000.0
IL2 signaling events mediated by STAT5	3.0	82.0	22.0	-0.065	0.046	1000.0	-1000.0	-0.055	-1000.0
IL23-mediated signaling events	3.0	209.0	60.0	-0.129	0.024	1000.0	-1000.0	-0.178	-1000.0
ErbB2/ErbB3 signaling events	2.0	136.0	65.0	-0.133	0.032	1000.0	-1000.0	-0.066	-1000.0
BARD1 signaling events	2.0	142.0	57.0	-0.132	0.031	1000.0	-1000.0	-0.07	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	208.0	85.0	-0.138	0.038	1000.0	-1000.0	-0.075	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	278.0	97.0	-0.142	0.031	1000.0	-1000.0	-0.095	-1000.0
IFN-gamma pathway	2.0	197.0	68.0	-0.455	0.065	1000.0	-1000.0	-0.097	-1000.0
Nectin adhesion pathway	2.0	146.0	63.0	-0.132	0.053	1000.0	-1000.0	-0.079	-1000.0
S1P5 pathway	2.0	48.0	17.0	-0.064	0.031	1000.0	-1000.0	-0.056	-1000.0
Ephrin B reverse signaling	2.0	110.0	48.0	-0.08	0.052	1000.0	-1000.0	-0.073	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	175.0	83.0	-0.295	0.048	1000.0	-1000.0	-0.081	-1000.0
IL2 signaling events mediated by PI3K	2.0	168.0	58.0	-0.061	0.058	1000.0	-1000.0	-0.093	-1000.0
Canonical Wnt signaling pathway	2.0	143.0	51.0	-0.214	0.104	1000.0	-1000.0	-0.055	-1000.0
Regulation of p38-alpha and p38-beta	2.0	126.0	54.0	-0.157	0.062	1000.0	-1000.0	-0.068	-1000.0
LPA receptor mediated events	2.0	224.0	102.0	-0.138	0.033	1000.0	-1000.0	-0.094	-1000.0
Arf6 trafficking events	2.0	142.0	71.0	-0.389	0.042	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by PRL	2.0	78.0	34.0	-0.03	0.022	1000.0	-1000.0	-0.043	-1000.0
S1P4 pathway	2.0	60.0	25.0	-0.064	0.028	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by HDAC Class II	1.0	89.0	75.0	-0.157	0.037	1000.0	-1000.0	-0.065	-1000.0
Visual signal transduction: Cones	1.0	40.0	38.0	-0.019	0.012	1000.0	-1000.0	-0.08	-1000.0
Cellular roles of Anthrax toxin	1.0	67.0	39.0	-0.193	0.019	1000.0	-1000.0	-0.035	-1000.0
Aurora A signaling	1.0	90.0	60.0	-0.142	0.036	1000.0	-1000.0	-0.06	-1000.0
HIF-2-alpha transcription factor network	1.0	64.0	43.0	-0.186	0.134	1000.0	-1000.0	-0.097	-1000.0
FAS signaling pathway (CD95)	1.0	81.0	47.0	-0.107	0.023	1000.0	-1000.0	-0.055	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	20.0	15.0	-0.007	0.025	1000.0	-1000.0	-0.029	-1000.0
Retinoic acid receptors-mediated signaling	1.0	70.0	58.0	-0.06	0.034	1000.0	-1000.0	-0.082	-1000.0
Class I PI3K signaling events	1.0	138.0	73.0	-0.051	0.028	1000.0	-1000.0	-0.075	-1000.0
IGF1 pathway	1.0	109.0	57.0	-0.04	0.044	1000.0	-1000.0	-0.098	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	34.0	33.0	-0.261	0.037	1000.0	-1000.0	-0.066	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	33.0	17.0	-0.017	0.026	1000.0	-1000.0	-0.053	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.046	1000.0	-1000.0	-0.072	-1000.0
Canonical NF-kappaB pathway	0.0	19.0	39.0	-0.019	0.079	1000.0	-1000.0	-0.101	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.012	0.043	1000.0	-1000.0	-0.071	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.012	1000.0	-1000.0	-0.042	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	54.0	65.0	-0.064	0.065	1000.0	-1000.0	-0.079	-1000.0
Arf6 downstream pathway	0.0	2.0	43.0	-0.024	0.025	1000.0	-1000.0	-0.045	-1000.0
EPO signaling pathway	0.0	30.0	55.0	-0.05	0.076	1000.0	-1000.0	-0.107	-1000.0
mTOR signaling pathway	0.0	9.0	53.0	-0.003	0.032	1000.0	-1000.0	-0.058	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	63.0	68.0	-0.139	0.048	1000.0	-1000.0	-0.078	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	20.0	37.0	-0.039	0.033	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class III	0.0	14.0	40.0	-0.021	0.022	1000.0	-1000.0	-0.05	-1000.0
TRAIL signaling pathway	0.0	36.0	48.0	-0.024	0.045	1000.0	-1000.0	-0.077	-1000.0
ceramide signaling pathway	0.0	24.0	49.0	-0.016	0.046	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by HDAC Class I	0.0	82.0	104.0	-0.157	0.055	1000.0	-1000.0	-0.086	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.179	0.108	1000.0	-1000.0	-0.021	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.028	0.022	1000.0	-1000.0	-0.071	-1000.0
Atypical NF-kappaB pathway	0.0	6.0	31.0	-0.002	0.048	1000.0	-1000.0	-0.066	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	29.0	45.0	-0.025	0.06	1000.0	-1000.0	-0.1	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.003	0.029	1000.0	-1000.0	-0.059	-1000.0
Insulin Pathway	0.0	44.0	74.0	-0.032	0.036	1000.0	-1000.0	-0.106	-1000.0
VEGFR1 specific signals	0.0	48.0	56.0	-0.009	0.049	1000.0	-1000.0	-0.087	-1000.0
Rapid glucocorticoid signaling	0.0	7.0	20.0	-0.002	0.012	1000.0	-1000.0	-0.04	-1000.0
p38 MAPK signaling pathway	0.0	25.0	44.0	-0.03	0.043	1000.0	-1000.0	-0.069	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.006	0.031	1000.0	-1000.0	-0.054	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.012	1000.0	-1000.0	-0.071	-1000.0
Total	849	50972	7203	-33.8482632959	-1993.78473569	131000	-131000	-10.0258865282	-131000