E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.033 0.163 -9999.0 0.0 -0.534 13.0 13.0 KLHL20 0.007 0.086 0.203 1.0 -0.211 1.0 2.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.008 0.119 0.362 1.0 -0.338 11.0 12.0 ENAH -0.035 0.164 -9999.0 0.0 -0.533 13.0 13.0 AP1M1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.004 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.018 0.042 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.015 0.136 -9999.0 0.0 -0.401 13.0 13.0 RAPGEF1 -0.024 0.147 -9999.0 0.0 -0.465 12.0 12.0 CTNND1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.17 -9999.0 0.0 -0.546 13.0 13.0 CRK -0.036 0.15 -9999.0 0.0 -0.491 13.0 13.0 E-cadherin/gamma catenin/alpha catenin 0.002 0.141 -9999.0 0.0 -0.434 13.0 13.0 alphaE/beta7 Integrin 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.034 0.164 -9999.0 0.0 -0.534 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.013 0.061 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.042 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.013 0.08 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.014 0.156 -9999.0 0.0 -0.499 13.0 13.0 TIAM1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.015 0.131 -9999.0 0.0 -0.392 13.0 13.0 AKT1 -0.014 0.05 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.04 0.204 -9999.0 0.0 -0.679 13.0 13.0 RhoA/GDP 0.005 0.133 0.463 2.0 -0.338 12.0 14.0 actin cytoskeleton organization 0.014 0.073 0.197 4.0 -0.155 1.0 5.0 CDC42/GDP 0.008 0.142 0.407 5.0 -0.337 12.0 17.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.011 0.091 -9999.0 0.0 -0.294 13.0 13.0 ITGB7 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.017 0.139 -9999.0 0.0 -0.414 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.002 0.126 -9999.0 0.0 -0.39 13.0 13.0 mol:GDP -0.009 0.156 0.537 3.0 -0.392 12.0 15.0 CDC42/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.002 0.124 -9999.0 0.0 -0.346 12.0 12.0 RAC1/GTP/IQGAP1 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.024 0.073 0.23 8.0 -9999.0 0.0 8.0 NME1 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.035 0.164 -9999.0 0.0 -0.534 13.0 13.0 regulation of cell-cell adhesion -0.008 0.075 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.006 0.033 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.001 0.103 -9999.0 0.0 -0.324 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.025 0.132 -9999.0 0.0 -0.395 12.0 12.0 CCND1 0.02 0.065 0.188 6.0 -9999.0 0.0 6.0 VAV2 -0.04 0.208 -9999.0 0.0 -0.504 22.0 22.0 RAP1/GDP 0.009 0.117 0.38 1.0 -0.338 2.0 3.0 adherens junction assembly -0.033 0.159 -9999.0 0.0 -0.515 13.0 13.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.013 0.124 -9999.0 0.0 -0.382 12.0 12.0 E-cadherin/beta catenin -0.03 0.13 -9999.0 0.0 -0.438 13.0 13.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.035 0.164 -9999.0 0.0 -0.534 13.0 13.0 PIK3CA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.029 0.104 -9999.0 0.0 -0.316 6.0 6.0 E-cadherin/beta catenin/alpha catenin 0.002 0.145 -9999.0 0.0 -0.449 13.0 13.0 ITGAE 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.03 0.174 -9999.0 0.0 -0.56 13.0 13.0