Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.016 0.128 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.057 0.248 -9999.0 0.0 -0.703 18.0 18.0 SHH Np/Cholesterol/GAS1 0.002 0.082 -9999.0 0.0 -0.375 6.0 6.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.081 0.373 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.019 0.155 -9999.0 0.0 -0.442 13.0 13.0 SMO -0.028 0.153 -9999.0 0.0 -0.464 13.0 13.0 AKT1 -0.019 0.148 -9999.0 0.0 -0.679 4.0 4.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.027 0.151 -9999.0 0.0 -0.457 13.0 13.0 STIL 0.004 0.128 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.009 0.12 -9999.0 0.0 -0.512 7.0 7.0 DHH N/PTCH1 -0.03 0.165 -9999.0 0.0 -0.392 22.0 22.0 PIK3CA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.153 -9999.0 0.0 -0.679 7.0 7.0 PTHLH -0.027 0.156 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.027 0.151 -9999.0 0.0 -0.457 13.0 13.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.027 0.155 -9999.0 0.0 -0.472 2.0 2.0 IHH N/Hhip -0.051 0.202 -9999.0 0.0 -0.482 25.0 25.0 DHH N/Hhip -0.017 0.178 -9999.0 0.0 -0.581 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.027 0.151 -9999.0 0.0 -0.457 13.0 13.0 pancreas development -0.013 0.153 -9999.0 0.0 -0.678 7.0 7.0 HHAT 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.13 -9999.0 0.0 -0.679 5.0 5.0 somite specification -0.027 0.151 -9999.0 0.0 -0.457 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.016 0.112 -9999.0 0.0 -0.33 12.0 12.0 SHH Np/Cholesterol/PTCH2 0.016 0.039 -9999.0 0.0 -0.411 1.0 1.0 SHH Np/Cholesterol/Megalin -0.032 0.141 -9999.0 0.0 -0.413 17.0 17.0 SHH 0.005 0.045 -9999.0 0.0 -0.516 1.0 1.0 catabolic process -0.023 0.146 -9999.0 0.0 -0.403 18.0 18.0 SMO/Vitamin D3 -0.019 0.132 -9999.0 0.0 -0.401 13.0 13.0 SHH Np/Cholesterol/Hhip -0.005 0.096 -9999.0 0.0 -0.39 8.0 8.0 LRP2 -0.053 0.224 -9999.0 0.0 -0.679 16.0 16.0 receptor-mediated endocytosis -0.055 0.19 -9999.0 0.0 -0.681 8.0 8.0 SHH Np/Cholesterol/BOC 0.017 0.038 -9999.0 0.0 -0.411 1.0 1.0 SHH Np/Cholesterol/CDO 0.015 0.039 -9999.0 0.0 -0.411 1.0 1.0 mesenchymal cell differentiation 0.005 0.096 0.387 8.0 -9999.0 0.0 8.0 mol:Vitamin D3 0.012 0.136 -9999.0 0.0 -0.333 12.0 12.0 IHH N/PTCH2 -0.021 0.165 -9999.0 0.0 -0.451 18.0 18.0 CDON 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.016 0.151 -9999.0 0.0 -0.408 18.0 18.0 Megalin/LRPAP1 -0.023 0.175 -9999.0 0.0 -0.513 16.0 16.0 PTCH2 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.009 0.036 -9999.0 0.0 -0.409 1.0 1.0 PTCH1 -0.023 0.147 -9999.0 0.0 -0.404 18.0 18.0 HHIP -0.013 0.153 -9999.0 0.0 -0.679 7.0 7.0