Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.007 0.092 -9999.0 0.0 -0.293 13.0 13.0 epithelial cell differentiation 0.01 0.128 -9999.0 0.0 -0.388 13.0 13.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.019 0.11 0.417 3.0 -9999.0 0.0 3.0 EGFR 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.027 0.127 0.347 2.0 -0.376 13.0 15.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.017 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.076 0.197 -9999.0 0.0 -0.594 14.0 14.0 CTNND1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.027 0.126 0.345 2.0 -0.37 13.0 15.0 regulation of calcium-dependent cell-cell adhesion -0.049 0.147 0.345 2.0 -0.389 18.0 20.0 EGF -0.581 0.236 -9999.0 0.0 -0.668 123.0 123.0 NCKAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.19 0.281 -9999.0 0.0 -0.591 42.0 42.0 cortical microtubule organization 0.01 0.128 -9999.0 0.0 -0.388 13.0 13.0 GO:0000145 -0.026 0.12 0.334 2.0 -0.353 13.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.014 0.131 -9999.0 0.0 -0.392 13.0 13.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.044 0.091 -9999.0 0.0 -0.339 11.0 11.0 ARF6 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.027 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.019 0.11 -9999.0 0.0 -0.346 12.0 12.0 PVRL2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.031 0.115 -9999.0 0.0 -0.376 12.0 12.0 ARF6/GTP 0.062 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.04 0.204 -9999.0 0.0 -0.679 13.0 13.0 EGFR/EGFR/EGF/EGF -0.302 0.186 -9999.0 0.0 -0.414 90.0 90.0 RhoA/GDP 0.013 0.124 -9999.0 0.0 -0.372 13.0 13.0 actin cytoskeleton organization -0.027 0.122 0.332 2.0 -0.364 13.0 15.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.006 0.117 -9999.0 0.0 -0.679 4.0 4.0 DIAPH1 0.029 0.111 -9999.0 0.0 -0.532 2.0 2.0 Wnt receptor signaling pathway -0.01 0.128 0.388 13.0 -9999.0 0.0 13.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.045 0.092 -9999.0 0.0 -0.343 11.0 11.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.028 0.125 0.334 2.0 -0.372 13.0 15.0 EFNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.029 0.119 0.34 1.0 -0.36 13.0 14.0 Ephrin A1/EPHA2 0.005 0.12 -9999.0 0.0 -0.365 13.0 13.0 SEC6/SEC8 -0.043 0.096 -9999.0 0.0 -0.352 12.0 12.0 MGAT3 -0.05 0.15 0.347 2.0 -0.396 18.0 20.0 HGF/MET -0.008 0.134 -9999.0 0.0 -0.392 14.0 14.0 HGF 0.002 0.117 -9999.0 0.0 -0.679 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.007 0.092 -9999.0 0.0 -0.295 13.0 13.0 actin cable formation 0.016 0.14 0.497 6.0 -0.289 1.0 7.0 KIAA1543 -0.025 0.122 0.336 2.0 -0.359 13.0 15.0 KIFC3 -0.041 0.11 -9999.0 0.0 -0.376 13.0 13.0 NCK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.128 0.347 2.0 -0.375 13.0 15.0 NCK1/GIT1 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.01 0.128 -9999.0 0.0 -0.388 13.0 13.0 EXOC4 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.041 0.109 -9999.0 0.0 -0.376 13.0 13.0 PIP5K1C -0.027 0.127 0.347 2.0 -0.376 13.0 15.0 LIMA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.011 0.137 0.417 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.006 0.131 0.313 8.0 -0.325 13.0 21.0 IGF-1R heterotetramer/IGF1 -0.005 0.135 -9999.0 0.0 -0.367 17.0 17.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.018 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.026 0.129 0.347 2.0 -0.376 13.0 15.0 mol:GTP 0.055 0.026 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.015 0.122 0.329 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.007 0.092 -9999.0 0.0 -0.293 13.0 13.0 regulation of cell-cell adhesion -0.027 0.122 0.332 2.0 -0.364 13.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.007 0.092 -9999.0 0.0 -0.295 13.0 13.0