Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	62.0	2117.0	34.0	-0.483	0.027	1000.0	-1000.0	-0.044	-1000.0
FOXA2 and FOXA3 transcription factor networks	44.0	2032.0	46.0	-1.151	0.029	1000.0	-1000.0	-0.092	-1000.0
EGFR-dependent Endothelin signaling events	43.0	908.0	21.0	-0.581	0.036	1000.0	-1000.0	-0.048	-1000.0
Angiopoietin receptor Tie2-mediated signaling	41.0	3638.0	88.0	-0.82	0.087	1000.0	-1000.0	-0.063	-1000.0
PDGFR-alpha signaling pathway	27.0	1214.0	44.0	-0.273	0.036	1000.0	-1000.0	-0.052	-1000.0
Thromboxane A2 receptor signaling	23.0	2443.0	105.0	-0.581	0.09	1000.0	-1000.0	-0.045	-1000.0
Glypican 1 network	20.0	976.0	48.0	-0.369	0.05	1000.0	-1000.0	-0.038	-1000.0
BMP receptor signaling	15.0	1235.0	81.0	-0.388	0.052	1000.0	-1000.0	-0.044	-1000.0
Signaling mediated by p38-alpha and p38-beta	15.0	673.0	44.0	-0.123	0.026	1000.0	-1000.0	-0.029	-1000.0
Arf6 signaling events	14.0	880.0	62.0	-0.581	0.057	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	14.0	1147.0	78.0	-0.259	0.06	1000.0	-1000.0	-0.077	-1000.0
Endothelins	12.0	1211.0	96.0	-0.572	0.045	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	12.0	1589.0	125.0	-0.12	0.059	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by PTP1B	11.0	874.0	76.0	-0.584	0.087	1000.0	-1000.0	-0.038	-1000.0
IL4-mediated signaling events	11.0	1072.0	91.0	-0.848	0.436	1000.0	-1000.0	-0.111	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	11.0	1321.0	120.0	-0.268	0.127	1000.0	-1000.0	-0.052	-1000.0
amb2 Integrin signaling	10.0	844.0	82.0	-0.442	0.048	1000.0	-1000.0	-0.046	-1000.0
Integrins in angiogenesis	10.0	915.0	84.0	-0.451	0.057	1000.0	-1000.0	-0.058	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	10.0	699.0	68.0	-0.475	0.063	1000.0	-1000.0	-0.077	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	792.0	74.0	-0.581	0.062	1000.0	-1000.0	-0.073	-1000.0
Ceramide signaling pathway	9.0	704.0	76.0	-0.581	0.203	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	9.0	333.0	36.0	-0.111	0.026	1000.0	-1000.0	-0.045	-1000.0
FoxO family signaling	8.0	539.0	64.0	-0.902	0.062	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by the Hedgehog family	7.0	393.0	52.0	-0.057	0.038	1000.0	-1000.0	-0.046	-1000.0
Glucocorticoid receptor regulatory network	7.0	800.0	114.0	-0.527	0.121	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling in keratinocytes	7.0	331.0	43.0	-0.218	0.031	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling events	7.0	39.0	5.0	-0.04	0.026	1000.0	-1000.0	0.007	-1000.0
p75(NTR)-mediated signaling	6.0	773.0	125.0	-0.427	0.072	1000.0	-1000.0	-0.08	-1000.0
Syndecan-3-mediated signaling events	6.0	217.0	35.0	-0.104	0.072	1000.0	-1000.0	-0.034	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	605.0	93.0	-0.246	0.118	1000.0	-1000.0	-0.056	-1000.0
Nongenotropic Androgen signaling	6.0	333.0	52.0	-0.124	0.051	1000.0	-1000.0	-0.046	-1000.0
Plasma membrane estrogen receptor signaling	6.0	566.0	86.0	-0.107	0.047	1000.0	-1000.0	-0.065	-1000.0
LPA4-mediated signaling events	5.0	71.0	12.0	-0.135	0.007	1000.0	-1000.0	-0.032	-1000.0
Caspase cascade in apoptosis	5.0	415.0	74.0	-0.405	0.065	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	5.0	382.0	76.0	-0.701	0.048	1000.0	-1000.0	-0.017	-1000.0
ErbB4 signaling events	5.0	346.0	69.0	-0.277	0.088	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	406.0	76.0	-0.04	0.047	1000.0	-1000.0	-0.065	-1000.0
IL23-mediated signaling events	5.0	305.0	60.0	-0.04	0.049	1000.0	-1000.0	-0.077	-1000.0
S1P3 pathway	5.0	216.0	42.0	-0.102	0.038	1000.0	-1000.0	-0.044	-1000.0
PDGFR-beta signaling pathway	5.0	502.0	97.0	-0.04	0.054	1000.0	-1000.0	-0.06	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	608.0	136.0	-0.471	0.091	1000.0	-1000.0	-0.046	-1000.0
Ephrin A  reverse signaling	4.0	30.0	7.0	-0.02	0.01	1000.0	-1000.0	-0.012	-1000.0
Noncanonical Wnt signaling pathway	4.0	121.0	26.0	-0.188	0.026	1000.0	-1000.0	-0.057	-1000.0
HIF-1-alpha transcription factor network	4.0	378.0	76.0	-0.107	0.112	1000.0	-1000.0	-0.07	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	380.0	85.0	-0.119	0.105	1000.0	-1000.0	-0.054	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	283.0	61.0	-0.148	0.078	1000.0	-1000.0	-0.044	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	401.0	82.0	-0.055	0.03	1000.0	-1000.0	-0.066	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	237.0	52.0	-0.264	0.079	1000.0	-1000.0	-0.054	-1000.0
Effects of Botulinum toxin	4.0	111.0	26.0	-0.18	0.047	1000.0	-1000.0	-0.011	-1000.0
IL27-mediated signaling events	4.0	231.0	51.0	-0.953	0.261	1000.0	-1000.0	-0.065	-1000.0
IL6-mediated signaling events	4.0	334.0	75.0	-0.213	0.04	1000.0	-1000.0	-0.05	-1000.0
Regulation of Telomerase	4.0	435.0	102.0	-0.58	0.067	1000.0	-1000.0	-0.044	-1000.0
Visual signal transduction: Rods	4.0	215.0	52.0	-0.16	0.053	1000.0	-1000.0	-0.049	-1000.0
Regulation of Androgen receptor activity	4.0	282.0	70.0	-0.821	0.043	1000.0	-1000.0	-0.048	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	70.0	17.0	-0.015	0.039	1000.0	-1000.0	-0.025	-1000.0
Osteopontin-mediated events	3.0	136.0	38.0	-0.087	0.054	1000.0	-1000.0	-0.042	-1000.0
Cellular roles of Anthrax toxin	3.0	117.0	39.0	-0.139	0.035	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	3.0	248.0	68.0	-0.344	0.065	1000.0	-1000.0	-0.071	-1000.0
Reelin signaling pathway	3.0	216.0	56.0	-0.104	0.064	1000.0	-1000.0	-0.051	-1000.0
ceramide signaling pathway	3.0	169.0	49.0	-0.0	0.042	1000.0	-1000.0	-0.048	-1000.0
TCGA08_p53	3.0	21.0	7.0	-0.022	0.026	1000.0	-1000.0	-0.006	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	53.0	15.0	-0.011	0.027	1000.0	-1000.0	-0.036	-1000.0
EPHB forward signaling	3.0	306.0	85.0	-0.099	0.071	1000.0	-1000.0	-0.079	-1000.0
Regulation of p38-alpha and p38-beta	3.0	171.0	54.0	-0.107	0.058	1000.0	-1000.0	-0.053	-1000.0
Calcium signaling in the CD4+ TCR pathway	3.0	118.0	31.0	-0.09	0.029	1000.0	-1000.0	-0.041	-1000.0
Wnt signaling	3.0	21.0	7.0	-0.017	0.026	1000.0	-1000.0	-0.025	-1000.0
TCGA08_rtk_signaling	3.0	98.0	26.0	-0.202	0.059	1000.0	-1000.0	-0.019	-1000.0
BCR signaling pathway	3.0	376.0	99.0	-0.064	0.057	1000.0	-1000.0	-0.06	-1000.0
Syndecan-4-mediated signaling events	3.0	220.0	67.0	-0.418	0.115	1000.0	-1000.0	-0.049	-1000.0
ErbB2/ErbB3 signaling events	2.0	180.0	65.0	-0.056	0.047	1000.0	-1000.0	-0.057	-1000.0
Syndecan-1-mediated signaling events	2.0	83.0	34.0	-0.035	0.027	1000.0	-1000.0	-0.056	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	83.0	28.0	-0.102	0.044	1000.0	-1000.0	-0.031	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	153.0	54.0	-0.034	0.045	1000.0	-1000.0	-0.055	-1000.0
Syndecan-2-mediated signaling events	2.0	189.0	69.0	-0.442	0.05	1000.0	-1000.0	-0.05	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	290.0	97.0	-0.088	0.058	1000.0	-1000.0	-0.068	-1000.0
PLK1 signaling events	2.0	217.0	85.0	-0.005	0.053	1000.0	-1000.0	-0.024	-1000.0
IL1-mediated signaling events	2.0	153.0	62.0	-0.125	0.073	1000.0	-1000.0	-0.063	-1000.0
S1P5 pathway	2.0	48.0	17.0	-0.016	0.026	1000.0	-1000.0	-0.024	-1000.0
Ephrin B reverse signaling	2.0	136.0	48.0	-0.035	0.036	1000.0	-1000.0	-0.039	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	172.0	83.0	-0.25	0.045	1000.0	-1000.0	-0.046	-1000.0
Canonical Wnt signaling pathway	2.0	143.0	51.0	-0.148	0.069	1000.0	-1000.0	-0.055	-1000.0
LPA receptor mediated events	2.0	249.0	102.0	-0.088	0.056	1000.0	-1000.0	-0.057	-1000.0
Arf6 trafficking events	2.0	191.0	71.0	-0.279	0.044	1000.0	-1000.0	-0.042	-1000.0
IGF1 pathway	2.0	127.0	57.0	-0.02	0.06	1000.0	-1000.0	-0.052	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.015	0.015	1000.0	-1000.0	-0.001	-1000.0
S1P4 pathway	2.0	66.0	25.0	-0.016	0.054	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class II	1.0	80.0	75.0	-0.109	0.065	1000.0	-1000.0	-0.039	-1000.0
IL12-mediated signaling events	1.0	129.0	87.0	-0.196	0.063	1000.0	-1000.0	-0.081	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	80.0	65.0	-0.016	0.063	1000.0	-1000.0	-0.048	-1000.0
EPO signaling pathway	1.0	72.0	55.0	-0.015	0.068	1000.0	-1000.0	-0.053	-1000.0
mTOR signaling pathway	1.0	66.0	53.0	-0.017	0.046	1000.0	-1000.0	-0.036	-1000.0
Nectin adhesion pathway	1.0	106.0	63.0	-0.04	0.057	1000.0	-1000.0	-0.045	-1000.0
HIF-2-alpha transcription factor network	1.0	84.0	43.0	-0.151	0.091	1000.0	-1000.0	-0.06	-1000.0
FAS signaling pathway (CD95)	1.0	61.0	47.0	-0.105	0.039	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by PI3K	1.0	88.0	58.0	-0.015	0.061	1000.0	-1000.0	-0.049	-1000.0
Class I PI3K signaling events	1.0	114.0	73.0	-0.018	0.043	1000.0	-1000.0	-0.05	-1000.0
TCGA08_retinoblastoma	1.0	10.0	8.0	-0.032	0.028	1000.0	-1000.0	-0.002	-1000.0
Insulin Pathway	1.0	74.0	74.0	-0.018	0.068	1000.0	-1000.0	-0.064	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	35.0	33.0	-0.037	0.061	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by PRL	1.0	58.0	34.0	-0.041	0.038	1000.0	-1000.0	-0.055	-1000.0
FOXM1 transcription factor network	1.0	76.0	51.0	-0.088	0.058	1000.0	-1000.0	-0.1	-1000.0
Aurora B signaling	1.0	105.0	67.0	-0.201	0.075	1000.0	-1000.0	-0.041	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	-0.013	0.045	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	0.0	6.0	39.0	-0.0	0.06	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	0.0	52.0	57.0	-0.052	0.064	1000.0	-1000.0	-0.05	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.008	0.025	1000.0	-1000.0	-0.015	-1000.0
Visual signal transduction: Cones	0.0	19.0	38.0	-0.016	0.052	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	0.0	3.0	22.0	-0.009	0.057	1000.0	-1000.0	-0.03	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	12.0	17.0	0.009	0.05	1000.0	-1000.0	-0.038	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.026	0.039	1000.0	-1000.0	-0.001	-1000.0
Aurora A signaling	0.0	11.0	60.0	-0.006	0.058	1000.0	-1000.0	-0.033	-1000.0
Arf6 downstream pathway	0.0	37.0	43.0	-0.042	0.042	1000.0	-1000.0	-0.034	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.008	0.046	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	0.0	25.0	32.0	-0.006	0.045	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	63.0	68.0	-0.022	0.053	1000.0	-1000.0	-0.04	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	2.0	37.0	-0.009	0.063	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by HDAC Class III	0.0	7.0	40.0	-0.047	0.047	1000.0	-1000.0	-0.028	-1000.0
TRAIL signaling pathway	0.0	4.0	48.0	-0.0	0.068	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class I	0.0	76.0	104.0	-0.109	0.064	1000.0	-1000.0	-0.041	-1000.0
Retinoic acid receptors-mediated signaling	0.0	51.0	58.0	-0.004	0.055	1000.0	-1000.0	-0.044	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.052	0.054	1000.0	-1000.0	-0.048	-1000.0
Atypical NF-kappaB pathway	0.0	2.0	31.0	0.0	0.038	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	30.0	45.0	0.002	0.073	1000.0	-1000.0	-0.054	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.002	0.021	1000.0	-1000.0	-0.004	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.061	1000.0	-1000.0	-0.044	-1000.0
IL2 signaling events mediated by STAT5	0.0	6.0	22.0	-0.004	0.039	1000.0	-1000.0	-0.052	-1000.0
VEGFR1 specific signals	0.0	45.0	56.0	-0.014	0.06	1000.0	-1000.0	-0.053	-1000.0
Rapid glucocorticoid signaling	0.0	3.0	20.0	-0.005	0.032	1000.0	-1000.0	-0.006	-1000.0
p38 MAPK signaling pathway	0.0	20.0	44.0	-0.0	0.047	1000.0	-1000.0	-0.032	-1000.0
Arf1 pathway	0.0	13.0	54.0	-0.001	0.051	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.07	1000.0	-1000.0	0.0	-1000.0
Total	691	45465	7203	-24.3552625856	7.81141093227	131000	-131000	-5.90479504327	-131000