E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.095 0.188 -9999.0 0.0 -0.441 32.0 32.0 KLHL20 -0.04 0.098 -9999.0 0.0 -0.196 35.0 35.0 CYFIP2 0.013 0.043 -9999.0 0.0 -0.381 2.0 2.0 Rac1/GDP -0.038 0.117 -9999.0 0.0 -0.229 35.0 35.0 ENAH -0.092 0.173 -9999.0 0.0 -0.406 33.0 33.0 AP1M1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.05 0.073 -9999.0 0.0 -0.239 14.0 14.0 ABI1/Sra1/Nap1 -0.05 0.061 -9999.0 0.0 -0.147 41.0 41.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.03 0.101 -9999.0 0.0 -0.199 32.0 32.0 RAPGEF1 -0.059 0.15 -9999.0 0.0 -0.342 32.0 32.0 CTNND1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.068 0.167 -9999.0 0.0 -0.399 31.0 31.0 CRK -0.069 0.162 -9999.0 0.0 -0.374 32.0 32.0 E-cadherin/gamma catenin/alpha catenin -0.064 0.126 -9999.0 0.0 -0.196 74.0 74.0 alphaE/beta7 Integrin 0.011 0.056 -9999.0 0.0 -0.199 11.0 11.0 IQGAP1 0.015 0.03 -9999.0 0.0 -0.381 1.0 1.0 NCKAP1 -0.046 0.132 -9999.0 0.0 -0.313 33.0 33.0 Rap1/GTP/I-afadin 0.004 0.065 -9999.0 0.0 -0.186 9.0 9.0 DLG1 -0.06 0.162 -9999.0 0.0 -0.396 29.0 29.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.036 0.054 -9999.0 0.0 -0.173 14.0 14.0 MLLT4 -0.037 0.121 -9999.0 0.0 -0.298 30.0 30.0 ARF6/GTP/NME1/Tiam1 0.003 0.068 -9999.0 0.0 -0.143 30.0 30.0 PI3K -0.045 0.068 -9999.0 0.0 -0.222 14.0 14.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.083 0.142 -9999.0 0.0 -0.239 71.0 71.0 TIAM1 -0.04 0.126 -9999.0 0.0 -0.31 30.0 30.0 E-cadherin(dimer)/Ca2+ -0.028 0.093 -9999.0 0.0 -0.179 34.0 34.0 AKT1 -0.023 0.042 -9999.0 0.0 -0.141 10.0 10.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.098 0.163 -9999.0 0.0 -0.319 59.0 59.0 RhoA/GDP -0.037 0.117 -9999.0 0.0 -0.229 35.0 35.0 actin cytoskeleton organization -0.028 0.073 -9999.0 0.0 -0.144 35.0 35.0 CDC42/GDP -0.037 0.117 -9999.0 0.0 -0.227 36.0 36.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.057 0.117 -9999.0 0.0 -0.226 46.0 46.0 ITGB7 0.005 0.066 -9999.0 0.0 -0.342 6.0 6.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.03 0.1 -9999.0 0.0 -0.191 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.032 0.087 -9999.0 0.0 -0.18 31.0 31.0 mol:GDP -0.052 0.131 -9999.0 0.0 -0.267 36.0 36.0 CDC42/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 JUP -0.026 0.123 -9999.0 0.0 -0.375 19.0 19.0 p120 catenin/RhoA/GDP -0.038 0.12 -9999.0 0.0 -0.248 29.0 29.0 RAC1/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 PIP5K1C/AP1M1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.027 0.068 -9999.0 0.0 -0.13 40.0 40.0 NME1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.084 0.166 -9999.0 0.0 -0.402 31.0 31.0 regulation of cell-cell adhesion -0.045 0.065 -9999.0 0.0 -0.211 14.0 14.0 WASF2 -0.024 0.033 -9999.0 0.0 -0.09 21.0 21.0 Rap1/GTP -0.033 0.103 -9999.0 0.0 -0.261 16.0 16.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.046 0.12 -9999.0 0.0 -0.212 46.0 46.0 CCND1 -0.033 0.082 -9999.0 0.0 -0.159 40.0 40.0 VAV2 -0.103 0.217 -9999.0 0.0 -0.457 40.0 40.0 RAP1/GDP -0.035 0.108 -9999.0 0.0 -0.26 17.0 17.0 adherens junction assembly -0.082 0.161 -9999.0 0.0 -0.39 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.039 0.114 -9999.0 0.0 -0.298 15.0 15.0 E-cadherin/beta catenin -0.052 0.111 -9999.0 0.0 -0.285 28.0 28.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.079 0.171 -9999.0 0.0 -0.396 33.0 33.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.096 0.131 -9999.0 0.0 -0.308 38.0 38.0 E-cadherin/beta catenin/alpha catenin -0.039 0.103 -9999.0 0.0 -0.214 31.0 31.0 ITGAE 0.009 0.047 -9999.0 0.0 -0.262 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.069 0.17 -9999.0 0.0 -0.408 31.0 31.0