rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(2), G6PD(2), GCLC(1), GGT1(4), GPX1(2), GPX4(1), GSTA4(1), GSTA5(3), GSTZ1(2), IDH1(167), IDH2(8), OPLAH(2) 7171644 195 178 23 11 164 11 3 15 2 0 <1.00e-15 <1.00e-15 <4.74e-14 2 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(2), ACO2(2), FH(1), IDH1(167), IDH2(8), IDH3B(1), OGDHL(2), PC(1), PCK1(3), SDHA(1), SDHC(1), SUCLG2(1) 9766691 193 177 22 7 163 10 2 15 3 0 <1.00e-15 <1.00e-15 <4.74e-14 3 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(2), FH(1), IDH1(167), IDH2(8) 2912395 180 176 9 0 160 7 0 12 1 0 <1.00e-15 <1.00e-15 <4.74e-14 4 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(2), E2F1(1), MDM2(2), PIK3CA(21), PIK3R1(14), POLR1A(4), POLR1B(2), RAC1(1), RB1(4), TBX2(1), TP53(154) 6628254 210 143 127 9 65 24 32 40 45 4 <1.00e-15 <1.00e-15 <4.74e-14 5 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(4), ATR(4), BAI1(2), BAX(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE2(1), CCNG2(1), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(6), CYCS(2), DDB2(2), EI24(2), FAS(1), GTSE1(4), IGFBP3(1), MDM2(2), MDM4(1), PPM1D(1), PTEN(13), RFWD2(3), SERPINE1(1), SESN1(1), SESN3(1), SIAH1(1), STEAP3(1), THBS1(1), TP53(154), TSC2(2), ZMAT3(3) 21303520 229 137 152 28 73 27 34 56 35 4 4.51e-10 <1.00e-15 <4.74e-14 6 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(8), DAXX(2), PAX3(1), PML(3), RB1(4), SP100(3), TNFRSF1B(2), TP53(154) 6202031 177 123 103 6 64 19 22 39 29 4 <1.00e-15 <1.00e-15 <4.74e-14 7 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNGR2(1), JAK2(3), NFKB1(1), NFKBIA(1), RB1(4), RELA(1), TNFRSF1B(2), TP53(154), WT1(1) 5925542 171 121 97 10 63 18 21 36 29 4 2.61e-13 <1.00e-15 <4.74e-14 8 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAX(1), BIRC2(1), CYCS(2), FAS(1), MAP3K1(2), MAP3K14(1), MAPK10(1), MDM2(2), NFKB1(1), NFKBIA(1), PARP1(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TP53(154), TRADD(1) 12209034 175 119 101 11 65 19 22 37 28 4 7.62e-14 <1.00e-15 <4.74e-14 9 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(4), ATR(4), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), RB1(4), SKP2(2), TGFB2(2), TGFB3(1), TP53(154) 9861667 184 119 110 8 67 21 25 39 28 4 1.11e-15 <1.00e-15 <4.74e-14 10 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(4), SP3(2), TP53(154), WT1(1) 2308742 161 119 86 2 62 18 20 35 22 4 <1.00e-15 <1.00e-15 <4.74e-14 11 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(3), AKT1(1), ATM(4), BAX(1), CPB2(1), CSNK1A1(2), CSNK1D(1), IGFBP3(1), MAPK8(1), MDM2(2), TP53(154) 6780040 171 118 97 8 63 19 23 38 24 4 2.53e-14 <1.00e-15 <4.74e-14 12 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), TP53(154) 3191452 160 117 86 6 60 19 20 33 24 4 5.43e-14 <1.00e-15 <4.74e-14 13 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CFL1(1), E2F1(1), MDM2(2), PRB1(3), TP53(154) 2743094 168 117 94 6 62 20 23 35 24 4 <1.00e-15 <1.00e-15 <4.74e-14 14 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(4), ATR(4), BRCA1(1), CDC25A(1), CDC34(1), CHEK1(3), CHEK2(6), EP300(3), MDM2(2), MYT1(3), PRKDC(9), RPS6KA1(2), TP53(154), WEE1(1), YWHAH(1), YWHAQ(1) 13622028 196 123 120 19 64 23 27 46 31 5 1.24e-09 1.11e-15 4.88e-14 15 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(4), ATR(4), CHEK1(3), CHEK2(6), TP53(154), YWHAH(1) 5232328 172 120 96 9 63 21 24 35 25 4 7.34e-11 1.22e-15 5.02e-14 16 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(2), ACO2(2), ACSS1(1), ACSS2(3), FH(1), IDH1(167), IDH2(8) 4350822 187 178 16 0 162 8 0 14 3 0 <1.00e-15 1.44e-15 5.56e-14 17 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(2), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CCND1(1), CHD8(1), CREBBP(8), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CTBP1(3), CUL1(1), CXXC4(1), DAAM1(1), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), LRP5(4), LRP6(5), MAPK10(1), MAPK8(1), MAPK9(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NKD2(1), NLK(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PORCN(4), PPP2CB(1), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(3), PRKACG(1), PRKCA(3), PRKCG(1), RAC1(1), RAC2(1), ROCK1(2), ROCK2(2), RUVBL1(1), SENP2(2), SFRP1(1), SFRP2(1), SFRP4(1), SIAH1(1), SMAD2(3), SMAD3(2), SOX17(2), TBL1XR1(1), TBL1Y(1), TCF7L2(2), TP53(154), VANGL1(1), VANGL2(1), WIF1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1) 52796946 297 139 223 43 105 42 34 70 41 5 1.63e-11 2.11e-15 7.64e-14 18 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(2), AKT1(1), APAF1(1), ATM(4), BAX(1), BIRC2(1), CASP10(1), CFLAR(1), CSF2RB(1), CYCS(2), DFFA(1), FAS(1), IL1B(1), IL1R1(1), IL1RAP(1), IL3RA(2), IRAK2(1), IRAK3(4), IRAK4(1), MAP3K14(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKAR1A(1), RELA(1), RIPK1(1), TNFRSF10C(1), TNFRSF10D(1), TP53(154), TRADD(1) 27293186 239 142 156 30 71 31 35 50 48 4 2.84e-09 2.33e-15 7.86e-14 19 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(2), FH(1), IDH1(167), IDH2(8), IDH3B(1), PC(1), PCK1(3), SDHA(1), SUCLG2(1) 6736397 187 176 16 2 161 10 1 13 2 0 <1.00e-15 2.55e-15 7.86e-14 20 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(1), ATM(4), BAX(1), CYCS(2), PRKCA(3), PTK2(1), STAT1(2), TLN1(2), TP53(154) 8947988 171 119 97 7 63 19 21 38 24 6 9.55e-15 2.55e-15 7.86e-14 21 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(4), BAX(1), CCND1(1), CDK2(1), CDK4(1), E2F1(1), MDM2(2), RB1(4), TIMP3(1), TP53(154) 5913556 171 120 97 5 62 19 24 36 26 4 <1.00e-15 2.78e-15 8.14e-14 22 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(2), G6PD(2), GCLC(1), GGT1(4), GPX1(2), GPX4(1), GSTA4(1), GSTZ1(2), IDH1(167), IDH2(8) 5906519 190 178 18 10 162 9 3 14 2 0 <1.00e-15 3.55e-15 9.40e-14 23 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(4), BRCA1(1), CHEK1(3), CHEK2(6), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(1), NFKBIA(1), RAD50(2), RBBP8(2), RELA(1), TP53(154) 9737552 184 120 108 15 65 24 26 39 26 4 1.08e-10 3.66e-15 9.40e-14 24 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(4), CDC25A(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(3), RB1(4), TP53(154), WEE1(1), YWHAH(1) 5748953 173 120 99 10 62 19 23 34 31 4 1.70e-11 3.66e-15 9.40e-14 25 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAX(1), BFAR(1), BTK(1), CAD(4), CASP10(1), CASP8AP2(2), CD7(1), CSNK1A1(2), DAXX(2), DFFA(1), DIABLO(1), EGFR(13), EPHB2(1), FAF1(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MET(6), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TNFRSF6B(1), TP53(154), TPX2(2), TUFM(1) 23699999 225 128 148 17 76 29 27 49 40 4 2.19e-14 3.89e-15 9.47e-14 26 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(1), CDKN1B(1), ITGB1(2), MAPK1(1), MAPK3(1), PIK3CA(21), PIK3R1(14), PTEN(13), PTK2(1), SHC1(1), SOS1(1) 6309735 58 43 49 5 5 7 11 10 24 1 0.00287 4.00e-15 9.47e-14 27 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(13), IGF1R(3), POLR2A(3), PRKCA(3), RB1(4), TEP1(7), TERF1(1), TP53(154), XRCC5(1) 9211942 190 129 113 7 67 22 25 43 28 5 <1.00e-15 4.33e-15 9.77e-14 28 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), DUSP4(1), GCK(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K9(3), MAPK10(1), MAPK7(3), MAPK8(1), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(4), SHC1(1), TP53(154) 16443203 193 119 119 14 71 22 29 41 26 4 8.02e-13 4.44e-15 9.77e-14 29 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAX(1), BCL2L11(1), BIRC2(1), CASP1(1), CASP10(1), CASP4(1), CYCS(2), DFFA(1), FAS(1), HELLS(2), IRF1(4), IRF2(1), IRF4(1), IRF6(1), IRF7(2), MAP3K1(2), MAPK10(1), MDM2(2), NFKB1(1), NFKBIA(1), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TNFRSF21(2), TP53(154), TRADD(1), TRAF3(1) 18683705 194 118 120 18 75 23 22 39 31 4 1.14e-11 5.00e-15 1.06e-13 30 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF4E(1), IGF1R(3), INPPL1(4), PIK3CA(21), PIK3R1(14), PTEN(13), RPS6KB1(1) 6433765 58 44 49 4 3 9 12 11 23 0 0.000705 6.00e-15 1.21e-13 31 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(4), ATR(4), BRCA1(1), BRCA2(4), CHEK1(3), CHEK2(6), FANCA(2), FANCC(1), FANCD2(3), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(2), RAD9A(1), TP53(154), TREX1(1) 14427561 195 124 119 13 68 26 27 42 28 4 4.37e-12 6.11e-15 1.21e-13 32 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(4), CCNA1(1), CCND1(1), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CREB3L1(1), E2F1(1), E2F3(1), E2F5(1), GBA2(1), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MYT1(3), POLE(7), PRIM1(1), RB1(4), RBL1(2), RPA1(2), TNXB(9), TP53(154), WEE1(1) 25174281 217 124 143 23 73 23 30 49 38 4 3.75e-11 6.33e-15 1.22e-13 33 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(2), GH1(1), GHR(2), IGF1R(3), PIK3CA(21), PIK3R1(14), SHC1(1), SOD2(1) 4357970 46 33 37 1 2 8 11 6 19 0 5.88e-05 7.11e-15 1.33e-13 34 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(21), PIK3R1(14), PLCB1(2), PLCG1(6), PRKCA(3), VAV1(4) 4199517 51 38 41 4 5 9 11 8 17 1 0.00263 8.10e-15 1.47e-13 35 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(3), EIF4A2(1), EIF4E(1), EIF4G1(3), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK3(1), PABPC1(4), PIK3CA(21), PIK3R1(14), PRKCA(3), PTEN(13), RPS6KB1(1) 9208005 76 52 67 9 8 14 13 12 27 2 0.00329 9.44e-15 1.66e-13 36 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(3), EIF4A2(1), EIF4B(1), EIF4E(1), EIF4G1(3), EIF4G2(1), EIF4G3(4), PIK3CA(21), PIK3R1(14), PTEN(13), RPS6KB1(1), TSC1(2), TSC2(2) 9033457 68 50 59 7 6 13 14 12 23 0 0.00170 2.71e-14 4.64e-13 37 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(1), CTLA4(1), HLA-DRA(2), ITK(1), PIK3CA(21), PIK3R1(14), PTPN11(6) 4192487 47 35 37 5 4 7 10 10 16 0 0.0184 3.50e-14 5.82e-13 38 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), PIK3CA(21), PIK3R1(14), PLCG1(6), PRKCA(3), SHC1(1), SOS1(1) 5093739 47 36 37 3 4 8 11 5 18 1 0.00182 8.43e-14 1.37e-12 39 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB2(1), CCNB3(3), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(2), CDC20(1), CDC25A(1), CDH1(3), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(6), DTX4(1), E2F1(1), E2F3(1), E2F5(1), EP300(3), ESPL1(5), HDAC2(5), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MPEG1(2), MPL(2), PLK1(1), PRKDC(9), PTPRA(4), RB1(4), RBL1(2), SKP2(2), TBC1D8(1), TP53(154), WEE1(1) 35831039 265 130 189 41 75 41 40 59 44 6 5.11e-08 2.87e-13 4.53e-12 40 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), ATM(4), ATR(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(2), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC27(4), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CHEK1(3), CHEK2(6), CREBBP(8), CUL1(1), DBF4(4), E2F1(1), E2F3(1), EP300(3), ESPL1(5), FZR1(2), HDAC2(5), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), PKMYT1(1), PLK1(1), PRKDC(9), RB1(4), RBL1(2), RBL2(2), SKP2(2), SMAD2(3), SMAD3(2), SMC1A(1), SMC1B(4), TGFB2(2), TGFB3(1), TP53(154), WEE1(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 44311378 296 137 219 45 80 45 44 68 53 6 1.99e-08 4.20e-13 6.46e-12 41 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(2), ELK1(3), INSR(3), IRS1(2), MAPK3(1), MAPK8(1), PIK3CA(21), PIK3R1(14), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(1), SRF(2) 8341624 63 42 53 8 7 13 10 12 20 1 0.00522 2.91e-12 4.37e-11 42 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), ELK1(3), IGF1R(3), IRS1(2), MAPK3(1), MAPK8(1), PIK3CA(21), PIK3R1(14), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2) 8115110 62 44 52 8 5 12 11 11 22 1 0.00629 4.07e-12 5.97e-11 43 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), PAK1(2), PDGFRA(8), PIK3CA(21), PIK3R1(14), RAC1(1), WASL(1) 4392268 51 34 42 6 1 10 10 8 22 0 0.0254 1.18e-11 1.68e-10 44 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), ELK1(3), MAPK3(1), MAPK8(1), NGFR(1), PIK3CA(21), PIK3R1(14), PLCG1(6), RAF1(1), SHC1(1), SOS1(1) 6245722 52 36 42 6 3 12 10 7 19 1 0.00763 3.78e-11 5.29e-10 45 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(1), BAX(1), CSF2RB(1), IGF1R(3), IL3RA(2), KIT(3), KITLG(2), PIK3CA(21), PIK3R1(14), PRKACG(1), PRKAR1A(1), YWHAH(1) 7178135 52 37 43 5 3 7 11 8 23 0 0.00522 9.61e-11 1.32e-09 46 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), IGF1R(3), IRS1(2), MAPK1(1), MAPK3(1), PIK3CA(21), PIK3R1(14), RAF1(1), SHC1(1), SOS1(1), YWHAH(1) 6210675 47 34 38 4 2 8 10 4 22 1 0.00341 1.07e-10 1.42e-09 47 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), GH1(1), GHR(2), NFKB1(1), NFKBIA(1), PIK3CA(21), PIK3R1(14), RELA(1), YWHAH(1) 4601266 43 32 34 5 3 7 10 5 18 0 0.0299 1.09e-10 1.42e-09 48 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), LIMK1(2), MAP3K1(2), MYL2(1), MYLK(3), NCF2(3), PAK1(2), PDGFRA(8), PIK3CA(21), PIK3R1(14), PLD1(5), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(4), VAV1(4), WASF1(1) 11423750 74 43 65 8 10 12 15 9 28 0 0.000465 2.20e-10 2.82e-09 49 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), JAK2(3), MAPK3(1), MPL(2), PIK3CA(21), PIK3R1(14), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), STAT1(2), STAT3(1), STAT5B(2) 9800906 64 41 54 5 7 9 11 12 22 3 0.000837 8.34e-10 1.05e-08 50 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(3), EGFR(13), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(21), PIK3R1(14), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1) 12263795 81 50 68 10 11 16 11 18 22 3 0.00186 1.31e-09 1.61e-08 51 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(1), ANXA1(2), GNAS(3), NFKB1(1), NOS3(5), NR3C1(2), PIK3CA(21), PIK3R1(14), RELA(1) 5843805 51 36 42 8 10 6 11 6 18 0 0.0653 3.29e-09 3.98e-08 52 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), E2F1(1), MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3CA(21), PIK3R1(14), RAC1(1), RAF1(1), RB1(4), RELA(1) 6610620 54 35 45 7 5 6 12 4 26 1 0.0150 4.80e-09 5.68e-08 53 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(2), INSR(3), IRS1(2), JAK2(3), MAPK1(1), MAPK3(1), PIK3CA(21), PIK3R1(14), PLCG1(6), PRKCA(3), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(1), SRF(2), STAT5B(2) 10814176 67 41 57 7 6 13 12 12 22 2 0.000979 1.22e-08 1.42e-07 54 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(1), MAPK1(1), MAPK3(1), MAPK7(3), MEF2A(2), MEF2B(1), PIK3CA(21), PIK3R1(14), PLCG1(6), RPS6KA1(2), SHC1(1) 6193940 54 37 44 8 4 11 10 8 20 1 0.0246 2.03e-08 2.32e-07 55 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(1), CHRNG(1), MUSK(4), PIK3CA(21), PIK3R1(14), PTK2(1), YWHAH(1) 5335534 44 32 35 6 3 6 10 6 19 0 0.0557 2.11e-08 2.36e-07 56 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(1), ITGB1(2), KLRC1(1), KLRC2(1), LAT(1), MAPK3(1), PAK1(2), PIK3CA(21), PIK3R1(14), RAC1(1), VAV1(4) 6097993 49 33 40 6 3 7 12 5 21 1 0.0157 4.62e-08 5.09e-07 57 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NFKB1(1), PIK3CA(21), PIK3R1(14), RB1(4), RELA(1) 6353736 50 34 41 7 7 7 10 4 21 1 0.0380 7.21e-08 7.79e-07 58 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), BPNT1(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CA(21), PIK3CD(1), PTEN(13), RBL2(2), SHC1(1), SOS1(1) 6663246 45 33 37 6 2 7 8 14 13 1 0.0216 1.36e-07 1.45e-06 59 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(1), CRKL(1), JAK2(3), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(21), PIK3R1(14), RAF1(1), SOS1(1), STAT1(2), STAT5B(2) 9184765 51 32 42 5 5 9 9 7 19 2 0.00437 1.99e-07 2.08e-06 60 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(2), AR(3), BRAF(3), DAG1(1), EGFR(13), GNA11(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), MAPK10(1), PHKA2(4), PIK3CA(21), PIK3CD(1), PIK3R1(14), PITX2(3), PTX3(1), RAF1(1) 17473771 94 52 82 15 14 15 20 22 22 1 0.00324 4.90e-07 5.03e-06 61 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 FURIN(1), NOTCH1(26) 3043447 27 19 24 3 6 3 1 4 10 3 0.0431 1.17e-06 1.18e-05 62 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(3), MAPK1(1), MAPK3(1), PIK3CA(21), PIK3R1(14), PRKACG(1), PRKAR1A(1), PRKCA(3), RAC1(1), RPS6KA1(2), SOS1(1) 9504545 56 37 47 6 6 7 10 7 24 2 0.00799 2.28e-06 2.26e-05 63 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), BCR(1), BTK(1), CDKN2A(2), FLOT1(1), FLOT2(1), ITPR1(2), ITPR2(11), ITPR3(6), PDK1(2), PHF11(1), PIK3CA(21), PITX2(3), PLCG2(7), PPP1R13B(1), PREX1(5), PTEN(13), PTPRC(4), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SAG(2), TEC(1), VAV1(4) 18055332 97 50 89 17 22 16 16 29 14 0 0.00283 3.09e-06 3.03e-05 64 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 CRKL(1), DOCK1(1), ELK1(3), HGF(2), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(6), PAK1(2), PIK3CA(21), PIK3R1(14), PTEN(13), PTK2(1), PTPN11(6), RAF1(1), RASA1(4), SOS1(1), STAT3(1) 14397179 85 53 75 16 11 11 14 19 29 1 0.0300 3.78e-06 3.64e-05 65 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), PIK3CA(21), PIK3R1(14), RAC1(1), RAF1(1), RALA(1), RALBP1(1), RALGDS(3), RELA(1) 6228774 50 33 41 8 5 7 10 6 21 1 0.0501 4.69e-06 4.44e-05 66 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(8), PIK3CA(21), PIK3R1(14), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1) 11425876 74 45 64 12 9 15 12 11 24 3 0.0176 7.35e-06 6.86e-05 67 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(3), EGF(3), EGFR(13), MET(6), PDGFRA(8), PRKCA(3), SH3GLB1(3), SH3KBP1(3) 6355468 42 23 39 9 10 8 4 13 6 1 0.0819 8.78e-06 8.08e-05 68 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), ELK1(3), MAP2K2(1), NGFR(1), PIK3CA(21), PIK3CD(1), SHC1(1), SOS1(1) 5274374 30 21 22 4 3 6 7 6 8 0 0.0299 1.03e-05 9.35e-05 69 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(8), EP300(3), FYN(1), JAK3(1), PIK3CA(21), PIK3R1(14), STAT5B(2) 9148853 50 32 41 8 5 7 9 11 18 0 0.0855 2.20e-05 0.000196 70 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGAP4(1), ARHGEF11(1), BTK(1), CFL1(1), GDI1(3), INPPL1(4), ITPR1(2), ITPR2(11), ITPR3(6), LIMK1(2), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PDK1(2), PIK3CA(21), PIK3CD(1), PIK3CG(4), PIK3R1(14), PITX2(3), PPP1R13B(1), PTEN(13), ROCK1(2), ROCK2(2), RPS4X(2), SAG(2), WASF1(1), WASL(1) 22917107 119 59 110 19 19 21 24 28 27 0 0.000894 2.33e-05 0.000205 71 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), BRD4(1), CDKN2A(2), FLOT1(1), FLOT2(1), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), LNPEP(1), MAPK1(1), MAPK3(1), PARD3(1), PARD6A(1), PDK1(2), PIK3CA(21), PIK3CD(1), PIK3R1(14), PPYR1(2), PTEN(13), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(1), SOS2(4), YWHAH(1), YWHAQ(1), YWHAZ(1) 19458344 96 53 86 16 10 15 15 26 29 1 0.0124 8.75e-05 0.000759 72 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), CPEB1(3), EGFR(13), ERBB2(1), ERBB4(4), ETS1(3), ETV6(2), ETV7(1), FMN2(2), KRAS(1), MAPK1(1), MAPK3(1), NOTCH1(26), NOTCH2(10), NOTCH3(4), NOTCH4(8), PIWIL2(3), PIWIL3(1), RAF1(1), SOS1(1), SOS2(4), SPIRE1(1), SPIRE2(2) 17125124 96 52 90 20 21 18 11 22 19 5 0.0256 0.000100 0.000857 73 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(1), BTK(1), CDKN2A(2), IARS(1), INPP5D(2), PDK1(2), PIK3CA(21), PPP1R13B(1), PTEN(13), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SHC1(1), SOS1(1), SOS2(4), TEC(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 11755033 61 39 53 10 6 8 11 21 15 0 0.0367 0.000108 0.000907 74 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(1), DIAPH1(3), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PIK3CA(21), PIK3R1(14), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), TLN1(2) 12205686 58 35 49 8 8 7 12 9 21 1 0.0111 0.000109 0.000907 75 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(1), GNAI1(1), ITGAV(2), ITGB3(2), MAPK1(1), MAPK3(1), PDGFA(1), PDGFRA(8), PIK3CA(21), PIK3R1(14), PLCB1(2), PRKCA(3), PTK2(1), RAC1(1), SMPD1(1), SMPD2(1) 8983287 62 37 53 11 5 10 12 7 26 2 0.0403 0.000118 0.000966 76 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PIK3CA(21), PIK3R1(14), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(1), VAV1(4) 14080808 73 42 63 11 12 12 13 14 21 1 0.00724 0.000121 0.000978 77 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), ELK1(3), FYN(1), LAT(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(1), PIK3CA(21), PIK3R1(14), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(1), VAV1(4), ZAP70(3) 15637024 85 46 75 14 20 13 12 14 24 2 0.00451 0.000125 0.000999 78 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(4), GPX1(2) 2578270 19 13 18 4 5 4 1 5 4 0 0.247 0.000134 0.00106 79 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(6), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(3), MAPK7(3), MEF2A(2), MEF2B(1), NFATC1(1), NFATC2(4), PIK3CA(21), PIK3R1(14), PPP3CA(1), PPP3CC(1), YWHAH(1) 11368531 64 37 55 12 12 12 11 8 21 0 0.0319 0.000263 0.00205 80 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4B(3), INPP5B(2), INPPL1(4), IPMK(1), ISYNA1(2), ITGB1BP3(1), ITPK1(2), MINPP1(1), OCRL(4), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIP4K2A(1), PIP4K2B(2), PIP4K2C(2), PIP5K1C(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(7), PLCZ1(3), PTEN(13), SYNJ1(4), SYNJ2(7) 24295096 117 57 108 19 23 22 16 33 23 0 0.000569 0.000288 0.00221 81 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(2), AKT1(1), CALR(2), CAMK1G(1), CAMK4(2), CREBBP(8), CSNK1A1(2), F2(2), MAPK1(1), MAPK3(1), MAPK8(1), MYH2(9), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PIK3CA(21), PIK3R1(14), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), RAF1(1), RPS6KB1(1) 16588548 83 43 74 13 18 12 11 16 25 1 0.00270 0.000304 0.00231 82 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(13), ERBB3(2), NRG1(2) 3372573 20 15 17 3 6 4 0 8 2 0 0.157 0.000358 0.00269 83 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), BTK(1), FYN(1), GAB2(1), INPP5D(2), KRAS(1), LAT(1), MAP2K2(1), MAP2K3(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(7), PRKCA(3), RAC1(1), RAC2(1), RAF1(1), SOS1(1), SOS2(4), VAV1(4), VAV2(1), VAV3(5) 23592994 111 60 99 21 25 19 19 18 28 2 0.00352 0.000411 0.00305 84 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), F2(2), GNAI1(1), PIK3CA(21), PIK3R1(14), PLCB1(2), PRKCA(3), ROCK1(2) 8448319 47 32 38 8 4 7 11 5 19 1 0.0612 0.000523 0.00384 85 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), BRAF(3), CREB1(1), CREBBP(8), CRKL(1), DAG1(1), EGR1(1), EGR3(1), ELK1(3), FRS2(1), MAP1B(5), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), OPN1LW(1), PIK3C2G(1), PIK3CA(21), PIK3CD(1), PIK3R1(14), PTPN11(6), RPS6KA3(2), SHC1(1), TH(1) 16773553 85 46 75 17 14 13 15 20 22 1 0.0205 0.000640 0.00464 86 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK5(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PIK3CA(21), PIK3CD(1), PIK3R1(14), TRAF3(1), TRAF5(1) 10962826 58 36 49 10 9 9 11 8 20 1 0.0236 0.000964 0.00690 87 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(5) 662761 5 5 5 0 3 1 0 0 1 0 0.247 0.000976 0.00691 88 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(3), EGFR(13), HGS(3), TF(1), TFRC(1) 4187712 23 16 20 4 5 6 1 9 2 0 0.137 0.00168 0.0118 89 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), APOA1(1), CD36(3), CITED2(1), CREBBP(8), EHHADH(1), EP300(3), HSD17B4(2), LPL(2), MAPK1(1), MAPK3(1), ME1(1), NCOA1(1), NCOR1(8), NCOR2(3), NFKBIA(1), NR1H3(4), NRIP1(1), PDGFA(1), PIK3CA(21), PIK3R1(14), PPARA(2), PRKACG(1), PRKAR1A(1), PRKCA(3), PTGS2(2), RB1(4), RELA(1), RXRA(1), STAT5B(2) 20675055 96 52 86 20 11 16 15 21 30 3 0.0589 0.00262 0.0181 90 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), CISH(1), IARS(1), IL13RA1(1), INPP5D(2), JAK2(3), JAK3(1), PI3(1), PIK3CA(21), PPP1R13B(1), RPS6KB1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3), TYK2(5) 12068705 49 28 41 4 8 6 10 13 12 0 0.00120 0.00336 0.0230 91 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 3315078 18 10 18 2 3 3 3 6 3 0 0.0780 0.00554 0.0375 92 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(2), AXIN1(1), BTRC(1), FZD1(1), NOTCH1(26) 7006790 31 20 28 6 6 4 1 6 11 3 0.241 0.00795 0.0532 93 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), CFLAR(1), CRKL(1), E2F1(1), IL2RB(1), IRS1(2), JAK3(1), MAPK1(1), MAPK3(1), PIK3CA(21), PIK3R1(14), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(1), STAT5B(2) 11820038 51 33 42 8 3 10 9 8 20 1 0.0313 0.00901 0.0597 94 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), KDR(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NOS3(5), NRAS(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(7), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTGS2(2), PTK2(1), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2) 23523326 120 60 110 25 32 17 24 17 28 2 0.00332 0.00946 0.0620 95 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), AKT1(1), ARAF(1), AREG(2), BRAF(3), BTC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CBLB(1), CBLC(1), CDKN1B(1), CRKL(1), EGF(3), EGFR(13), ELK1(3), ERBB2(1), ERBB3(2), ERBB4(4), KRAS(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NCK1(1), NRAS(1), NRG1(2), NRG2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PLCG1(6), PLCG2(7), PRKCA(3), PRKCG(1), PTK2(1), RAF1(1), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), STAT5B(2) 33657003 143 68 130 25 32 23 19 32 35 2 0.000525 0.00992 0.0644 96 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), CDK2(1), CDKN1B(1), CDKN2A(2), CREB1(1), ERBB4(4), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), MET(6), NOLC1(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PARD3(1), PARD6A(1), PDK1(2), PIK3CA(21), PIK3CD(1), PPP1R13B(1), PREX1(5), PTEN(13), PTK2(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SHC1(1), SLC2A4(1), SOS1(1), SOS2(4), TSC1(2), TSC2(2), YWHAH(1), YWHAQ(1), YWHAZ(1) 25253524 107 51 98 23 15 16 19 31 26 0 0.0230 0.0219 0.141 97 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(1), FMOD(1), KERA(2), LUM(2) 1186959 8 7 8 3 1 1 2 4 0 0 0.701 0.0251 0.160 98 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(1), AGPS(2), ENPP2(3), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(5), PPAP2A(2), PPAP2C(1) 7574393 34 16 34 6 6 5 6 12 5 0 0.0657 0.0304 0.191 99 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(1), CDKN1B(1), CUL1(1), E2F1(1), RB1(4), SKP2(2), UBE2M(1) 2798648 11 8 11 1 1 1 4 1 4 0 0.172 0.0341 0.212 100 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CDC34(1), CDK2(1), CUL1(1), E2F1(1), RB1(4), SKP2(2) 2788860 11 8 11 1 1 1 4 1 4 0 0.191 0.0349 0.215 101 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(2), GAD2(1), GGT1(4) 1879746 7 6 7 0 2 1 2 2 0 0 0.0979 0.0391 0.238 102 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), IRS1(2), IRS2(1), JAK3(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CA(21), PIK3CD(1), PIK3R1(14), PPP1R13B(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3) 11912016 56 36 47 11 5 9 11 11 19 1 0.0942 0.0498 0.300 103 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), BCR(1), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(3), CSK(1), DAG1(1), FLOT1(1), FLOT2(1), INPP5D(2), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(4), PDK1(2), PIK3CA(21), PIK3CD(1), PIK3R1(14), PLCG2(7), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(4), RAF1(1), SHC1(1), SOS1(1), SOS2(4), VAV1(4) 24167563 105 53 96 23 24 17 18 22 23 1 0.0186 0.0502 0.300 104 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(4), SHMT1(1) 1356911 6 5 6 1 2 1 2 1 0 0 0.303 0.0606 0.359 105 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(2), AXIN1(1), CCND1(1), FZD1(1), GJA1(4), GNAI1(1), LBP(1), NFKB1(1), PIK3CA(21), PIK3R1(14), RELA(1) 10046773 49 33 40 11 5 9 10 7 18 0 0.215 0.0687 0.403 106 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), NAT1(1), NAT2(2), XDH(7) 2605500 12 7 12 0 4 1 0 5 2 0 0.0359 0.0697 0.405 107 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(4), GLS(1), GLUD1(3), GOT1(2) 2551489 12 6 12 2 1 2 0 4 5 0 0.440 0.0856 0.493 108 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), TYR(4) 3164578 10 7 10 1 2 1 1 4 2 0 0.236 0.102 0.580 109 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGT(2), AGTR2(1), EDNRB(1), EGF(3), EGFR(13), NFKB1(1), PLCG1(6), PRKCA(3), RELA(1) 6713886 31 18 27 9 7 7 2 12 2 1 0.336 0.106 0.599 110 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(1), PC(1), PDHA1(2), SLC25A1(1) 3033268 8 7 8 0 1 2 0 3 2 0 0.0677 0.110 0.616 111 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), BCR(1), BLNK(2), BTK(1), CSK(1), DAG1(1), EPHB2(1), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(21), PIK3CD(1), PIK3R1(14), PLCG2(7), PPP1R13B(1), RAF1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), VAV1(4) 17211738 74 44 65 17 17 11 12 12 22 0 0.0690 0.124 0.687 112 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL12B(2), IL15(2), IL16(6), IL6(1), IL9(1) 3243523 13 8 13 3 1 0 3 5 4 0 0.565 0.153 0.840 113 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), PTGS1(2), PTGS2(2) 1749706 6 5 6 0 3 0 0 2 1 0 0.263 0.166 0.907 114 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(13), MAP3K1(2), NCOR2(3), RXRA(1) 5646734 22 16 19 6 5 6 0 9 2 0 0.341 0.176 0.947 115 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), CDK2(1), CUL1(1), E2F1(1), FBXW7(1), RB1(4) 2694035 9 6 9 1 1 1 2 1 4 0 0.326 0.177 0.947 116 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(1), HLA-DRA(2), IFNB1(1), IL12B(2), IL15(2), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1) 4292787 13 8 13 1 3 0 3 6 1 0 0.133 0.183 0.971 117 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), ENPP1(1), ENPP3(2), NADSYN1(3), NNMT(1), NNT(3), NT5C(2), NT5E(1), NT5M(1) 4754155 17 8 17 0 1 6 3 5 2 0 0.00418 0.189 0.996 118 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGEF6(3), BCAR1(1), BRAF(3), CDKN2A(2), DOCK1(1), EPHB2(1), FYN(1), GRB7(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MRAS(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PIK3CA(21), PIK3CB(1), PKLR(1), PLCG1(6), PLCG2(7), PTEN(13), PTK2(1), RAF1(1), RALA(1), ROCK1(2), ROCK2(2), SHC1(1), SOS1(1), SOS2(4), TLN1(2), TLN2(4), WAS(2) 39942361 141 58 132 26 32 19 21 39 30 0 0.000721 0.196 1.000 119 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(2), ITGA4(2), ITGAL(1), ITGB1(2), ITGB2(1), SELE(4) 3961834 14 10 13 4 6 4 2 1 1 0 0.277 0.199 1.000 120 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(5), MPO(2), PRDX1(1), TPO(3), TYR(4) 3153376 17 9 17 4 7 5 0 4 1 0 0.124 0.214 1.000 121 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5) 2616913 13 8 13 3 7 2 1 1 2 0 0.194 0.215 1.000 122 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5) 2616913 13 8 13 3 7 2 1 1 2 0 0.194 0.215 1.000 123 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(2) 776185 4 3 4 1 1 0 0 3 0 0 0.634 0.221 1.000 124 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(2), TAT(1), TYR(4) 1541543 8 5 8 3 3 0 1 4 0 0 0.754 0.221 1.000 125 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(1), TYR(4) 4908377 14 8 14 2 2 3 1 5 3 0 0.238 0.234 1.000 126 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), BRAF(3), CAB39(1), EIF4B(1), MAPK1(1), MAPK3(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), TSC1(2), TSC2(2), ULK2(5), VEGFA(2), VEGFB(1), VEGFC(2) 17367198 79 39 70 17 15 11 17 15 20 1 0.0444 0.235 1.000 127 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(4), NRG2(1), PRKCA(3) 2942732 8 5 8 0 1 1 2 2 1 1 0.0999 0.243 1.000 128 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), OXCT1(1), PDHA1(2), PDHA2(4) 8443299 31 16 31 8 12 6 2 5 6 0 0.101 0.245 1.000 129 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2) 4338548 24 11 24 5 10 1 2 8 3 0 0.128 0.251 1.000 130 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), UGDH(1) 2790874 15 8 15 2 9 2 1 1 2 0 0.0570 0.253 1.000 131 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGF(3), EGFR(13), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SPRY1(1), SPRY4(1) 8156906 32 20 29 7 7 4 2 11 7 1 0.223 0.253 1.000 132 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CRY1(2), CSNK1E(1), PER1(4) 2785609 9 5 9 0 2 2 1 2 2 0 0.102 0.260 1.000 133 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(10), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1) 12106195 40 21 39 6 12 10 4 9 5 0 0.0105 0.264 1.000 134 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(1), COQ6(1), NDUFB11(1) 1311079 4 3 4 0 0 2 0 2 0 0 0.310 0.266 1.000 135 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(3), PDHA1(2), PDHA2(4) 2274001 11 6 11 2 2 5 1 1 2 0 0.137 0.273 1.000 136 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(4), RXRA(1) 1779152 5 4 4 1 2 1 2 0 0 0 0.372 0.281 1.000 137 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(3), PRKACG(1), PRKAR1A(1), PRKCA(3) 3116976 10 7 10 2 2 0 1 4 2 1 0.621 0.283 1.000 138 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD1(3), GLUD2(1) 1486985 5 4 5 2 0 2 0 2 1 0 0.734 0.288 1.000 139 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(3), CTH(1), GGT1(4), MARS(4), MARS2(1), SCLY(2) 4048815 15 7 15 1 3 5 3 4 0 0 0.0224 0.290 1.000 140 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT1(1), GALNT12(2), GALNT14(2), GALNT2(2), GALNT4(2), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GCNT4(2), OGT(6), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 10562317 35 14 35 8 10 9 1 12 3 0 0.158 0.297 1.000 141 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT2(2), FUT5(2), FUT6(2) 1652917 7 4 7 3 3 1 1 1 1 0 0.780 0.299 1.000 142 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(1), CYP1A2(2), CYP2C19(5), CYP2C8(1), CYP3A7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 7812605 24 17 24 5 8 4 3 4 5 0 0.186 0.310 1.000 143 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(2) 1251006 4 3 4 1 0 1 2 0 1 0 0.624 0.317 1.000 144 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 862363 3 2 3 1 1 0 1 1 0 0 0.729 0.318 1.000 145 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(4), SP3(2) 2175476 6 4 6 0 1 0 1 1 3 0 0.248 0.324 1.000 146 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(10), ACACB(5), ACAT2(1), ACSS1(1), ACSS2(3), ACYP1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1) 15324012 49 25 48 9 17 11 5 10 6 0 0.0136 0.333 1.000 147 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), PAK1(2), PDE3A(2), PI3(1), PIK3C2G(1), PIK3CA(21), PIK3CD(1), PIK3R1(14), RPS4X(2), SGCB(1) 15916332 71 40 62 18 8 9 17 14 22 1 0.253 0.333 1.000 148 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(2), HK1(3), PFKL(2), PGAM1(1), PKLR(1), TPI1(1) 3032813 13 6 13 0 5 5 0 1 2 0 0.00331 0.339 1.000 149 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(4), SHMT1(1) 1795701 5 5 5 2 1 1 2 1 0 0 0.629 0.344 1.000 150 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), IDI1(1), SQLE(1) 1028226 3 2 3 0 0 0 3 0 0 0 0.337 0.347 1.000 151 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), BRAF(3), DAG1(1), EGFR(13), EPHB2(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(1), PITX2(3), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT3(1) 19130976 62 26 59 12 13 9 11 22 7 0 0.0259 0.350 1.000 152 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), CCL5(1), CSK(1), EGFR(13), F11R(1), GIT1(1), JAM2(3), JAM3(2), MAP3K14(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(1), MAPK9(1), MET(6), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(1), PAK1(2), PLCG1(6), PLCG2(7), PTPN11(6), PTPRZ1(7), RAC1(1), RELA(1), TCIRG1(1), TJP1(4) 22982936 87 38 82 20 23 16 9 22 16 1 0.0255 0.351 1.000 153 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(3) 1617433 6 3 6 1 2 0 1 2 0 1 0.394 0.368 1.000 154 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4B(3), INPPL1(4), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CA(21), PIK3CB(1), PIK3CG(4), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(7) 14645307 62 36 53 14 11 12 12 15 12 0 0.0857 0.372 1.000 155 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 GSTZ1(2), HGD(3) 728482 5 2 5 1 2 0 0 1 2 0 0.563 0.380 1.000 156 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(2), ELK1(3), IL6(1), IL6ST(2), JAK2(3), JAK3(1), MAPK3(1), PTPN11(6), RAF1(1), SHC1(1), SOS1(1), SRF(2), STAT3(1) 7804745 26 15 25 7 3 6 1 11 4 1 0.317 0.383 1.000 157 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT2(2), ST3GAL4(1) 2349093 10 5 10 3 4 0 2 2 2 0 0.527 0.384 1.000 158 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), NFKB1(1), NOX1(1), RELA(1), XDH(7) 3245706 12 5 11 4 2 2 0 5 3 0 0.673 0.386 1.000 159 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), CACNA1A(1), CACNA1B(7), GNAS(3), GRM4(2), ITPR3(6), KCNB1(2), PDE1A(1), PLCB2(1), PRKACG(1), SCNN1B(2), TAS1R2(3), TAS1R3(1), TAS2R1(2), TAS2R10(2), TAS2R13(1), TAS2R16(2), TAS2R3(1), TAS2R4(1), TAS2R40(1), TAS2R41(2), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R9(4), TRPM5(2) 18541990 55 29 55 9 19 9 3 15 9 0 0.0129 0.405 1.000 160 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3) 691028 3 2 3 0 1 1 0 1 0 0 0.365 0.409 1.000 161 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), OXCT1(1) 1107888 2 2 2 0 0 1 0 1 0 0 0.592 0.420 1.000 162 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(1), HLA-DRA(2) 996435 4 2 4 1 0 0 0 3 1 0 0.674 0.421 1.000 163 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(10), CPT1A(1), LEPR(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1) 4738591 19 7 18 2 4 2 1 9 3 0 0.0921 0.430 1.000 164 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACADS(1), ACAT2(1), ACSM1(3), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), ILVBL(3), OXCT1(1), PDHA1(2), PDHA2(4), PLA1A(2) 13262829 49 21 49 11 18 8 3 11 9 0 0.0457 0.437 1.000 165 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(2), ITGAL(1), ITGAM(1), ITGB2(1), SELE(4) 3395059 11 8 10 4 5 4 1 0 1 0 0.384 0.442 1.000 166 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(1), UXS1(2) 1595600 5 3 5 1 0 1 2 1 1 0 0.552 0.447 1.000 167 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), HTR2C(1), PLCB1(2), TUB(2) 2338960 6 4 6 2 2 1 0 2 1 0 0.574 0.451 1.000 168 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CREB1(1), DAXX(2), DDIT3(1), ELK1(3), MAP3K1(2), MAP3K5(2), MAP3K9(3), MAPKAPK2(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), PLA2G4A(4), RAC1(1), RIPK1(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1) 11960444 38 20 37 8 9 5 7 11 5 1 0.152 0.454 1.000 169 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(2), ITGA4(2), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(1), SELE(4), SELP(2) 5216686 17 11 16 6 6 4 3 3 1 0 0.450 0.466 1.000 170 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPP(2), GGH(1), SPR(1) 2123077 4 4 4 1 2 1 0 0 1 0 0.583 0.468 1.000 171 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), IDI1(1), SQLE(1) 1381539 3 2 3 0 0 0 3 0 0 0 0.329 0.486 1.000 172 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), PON1(3) 2937587 9 5 8 2 5 0 0 1 3 0 0.457 0.490 1.000 173 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(2), COL4A4(4), COL4A5(3), COL4A6(5), F2(2), F5(7), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), PROS1(1), SERPING1(1) 14533608 49 24 49 11 13 11 9 8 7 1 0.0398 0.501 1.000 174 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(4), CDC25A(1), CHEK1(3), MYT1(3), WEE1(1), YWHAH(1) 4500786 13 6 13 8 2 2 1 2 6 0 0.954 0.502 1.000 175 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CYP2C19(5), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), PNPLA3(1), SH3GLB1(3) 10094223 34 15 33 8 19 4 2 3 6 0 0.0958 0.502 1.000 176 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(1) 3502978 8 6 8 2 2 1 2 1 2 0 0.466 0.512 1.000 177 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2) 1847236 9 4 9 3 1 0 1 6 1 0 0.662 0.524 1.000 178 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(3), JAK3(1), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5) 3843701 12 5 12 3 3 0 0 5 3 1 0.506 0.532 1.000 179 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 595423 2 2 2 0 2 0 0 0 0 0 0.524 0.534 1.000 180 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(3), TYK2(5) 3432229 9 5 9 2 3 0 1 3 2 0 0.486 0.537 1.000 181 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(3), TYK2(5) 3432229 9 5 9 2 3 0 1 3 2 0 0.486 0.537 1.000 182 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(1), ACADS(1), ECHS1(2) 1766010 5 3 5 3 1 1 0 1 2 0 0.805 0.544 1.000 183 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ABAT(1), ADSL(3), ADSSL1(1), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), ASS1(1), CAD(4), CRAT(1), DARS2(2), GAD1(2), GAD2(1), GOT1(2), NARS2(1), PC(1), PDHA1(2), PDHA2(4) 12369170 35 16 35 5 10 9 2 8 6 0 0.0159 0.544 1.000 184 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(8), DFFA(1), PRF1(1), SET(1) 3452571 12 5 12 3 4 1 1 3 3 0 0.432 0.547 1.000 185 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(2), AGTR2(1), KNG1(1), NOS3(5), REN(1) 3242588 12 7 12 4 6 1 1 2 2 0 0.581 0.549 1.000 186 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), ATG7(3), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(2), PRKAA1(3), PRKAA2(2), ULK2(5) 6891181 25 8 25 2 5 2 5 8 5 0 0.0156 0.551 1.000 187 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2) 1564496 4 4 4 2 2 0 0 1 1 0 0.865 0.553 1.000 188 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 373921 1 1 1 1 0 1 0 0 0 0 0.899 0.553 1.000 189 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(1), MST1(5), MST1R(1) 2146039 7 3 7 2 2 3 0 2 0 0 0.397 0.559 1.000 190 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1), CFTR(2), GNAS(3), PRKACG(1), PRKAR1A(1), SLC9A3R1(1) 4251851 10 9 10 3 3 1 1 2 3 0 0.609 0.560 1.000 191 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), ENPP1(1), ENPP3(2), NADSYN1(3), NMNAT3(1), NNMT(1), NNT(3), NT5C(2), NT5E(1), NT5M(1) 7028279 18 8 18 1 1 7 3 5 2 0 0.0161 0.563 1.000 192 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1) 1269548 2 2 2 0 0 0 0 1 1 0 0.516 0.573 1.000 193 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PDXK(1) 1588407 4 2 4 2 0 2 0 2 0 0 0.818 0.573 1.000 194 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP68(2), SRP72(3), SRPR(3) 2468694 8 3 8 0 3 0 1 2 2 0 0.151 0.575 1.000 195 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B4(1), FLT1(3), FLT4(3), KDR(6), NOS3(5), PIK3CA(21), PIK3R1(14), PLCG1(6), PRKCA(3), PTK2(1), SHC1(1) 11123750 64 41 54 17 10 11 15 7 20 1 0.235 0.578 1.000 196 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(3), FDFT1(1), HMGCS1(1), IDI1(1), MVD(2), NSDHL(2), SQLE(1) 4305225 12 5 12 4 5 1 3 3 0 0 0.465 0.579 1.000 197 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(10), ACADL(1), ACADM(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), ECHS1(2), EHHADH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1) 10829006 40 15 39 10 12 11 2 10 5 0 0.139 0.581 1.000 198 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), ELK1(3), EPOR(1), JAK2(3), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1), STAT5B(2) 7019078 22 11 21 5 3 6 1 7 4 1 0.197 0.584 1.000 199 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LPL(2) 1744905 3 3 3 0 0 0 0 3 0 0 0.585 0.590 1.000 200 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK2(3), STAT1(2) 2674496 6 3 6 3 1 0 0 2 2 1 0.884 0.591 1.000 201 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(3), P2RY6(2) 1951749 9 3 9 4 5 2 0 2 0 0 0.573 0.591 1.000 202 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(2), F5(7), F7(2), FGA(4), FGB(1), PROS1(1) 5360112 17 12 17 5 6 1 4 4 2 0 0.382 0.594 1.000 203 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), PANK2(1), PANK4(2) 4546385 11 6 11 3 2 1 0 5 3 0 0.728 0.595 1.000 204 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), GRM1(4), PLCB1(2), PPP3CA(1), PRKACG(1), PRKAR1A(1) 5243365 10 7 10 3 0 1 0 6 3 0 0.877 0.595 1.000 205 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CHEK1(3), WEE1(1) 2242080 5 3 5 3 1 1 1 0 2 0 0.951 0.596 1.000 206 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), PRB1(3) 2913685 12 7 12 3 3 2 4 2 1 0 0.289 0.599 1.000 207 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(10), ACACB(5), ACADM(1), ACAT2(1), ACSS1(1), ACSS2(3), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), ALDH7A1(2), ECHS1(2), EHHADH(1), HIBCH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1) 12987039 50 19 49 13 17 12 4 11 6 0 0.101 0.607 1.000 208 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), ILVBL(3), PANK2(1), PANK4(2), VNN1(1) 5642594 15 8 15 3 3 2 0 6 4 0 0.452 0.613 1.000 209 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(8), EP300(3), NCOA3(1), PRKACG(1), PRKAR1A(1), RXRA(1) 6758725 16 8 16 4 3 2 0 6 5 0 0.513 0.617 1.000 210 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), UCHL3(1), UGDH(1), UGT1A1(6), UGT2B15(1), UGT2B4(2) 5753383 13 8 13 4 2 1 4 6 0 0 0.500 0.622 1.000 211 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), E2F1(1), RB1(4), RBL1(2) 5242883 18 8 18 4 4 2 5 3 4 0 0.278 0.623 1.000 212 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CXCR4(1), GNAI1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(1), PIK3CA(21), PIK3R1(14), PLCG1(6), PRKCA(3), PTK2(1), RAF1(1), RELA(1) 9028121 54 38 44 15 6 8 12 5 21 2 0.373 0.624 1.000 213 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(2) 977103 3 2 3 2 0 1 1 1 0 0 0.846 0.629 1.000 214 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(2), PPARG(1), RXRA(1) 1899443 7 6 7 4 1 1 1 4 0 0 0.814 0.632 1.000 215 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKACG(1), PRKAR1A(1), PTPRC(4), ZAP70(3) 7485787 26 13 26 6 7 4 0 10 5 0 0.322 0.632 1.000 216 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKACG(1), PRKAR1A(1), PTPRC(4), ZAP70(3) 7485787 26 13 26 6 7 4 0 10 5 0 0.322 0.632 1.000 217 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 MARCKS(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), SP3(2) 6843413 24 11 23 6 9 3 3 5 3 1 0.234 0.636 1.000 218 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACPP(1), ALPP(2), CYP3A7(1), DHRS2(2), DHRS3(1), DHRS7(1), PON1(3) 5877262 11 8 10 1 6 0 0 1 4 0 0.0989 0.638 1.000 219 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(2), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EARS2(2), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GFPT2(3), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), GNPNAT1(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1) 12904560 41 18 41 10 8 9 4 12 8 0 0.159 0.639 1.000 220 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(1), CFLAR(1), DAXX(2), DFFA(1), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(9), PTPN13(1), RB1(4), SPTAN1(2) 13226423 34 15 34 6 6 6 4 9 8 1 0.116 0.643 1.000 221 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(1), HLA-A(1), ICAM1(2), ITGAL(1), ITGB2(1), PRF1(1) 2863254 7 5 7 3 3 2 1 0 1 0 0.526 0.644 1.000 222 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(2), EHHADH(1) 1580429 5 2 5 4 2 0 1 0 2 0 0.868 0.648 1.000 223 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GLS(1), GLUD1(3), GLUL(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1) 10840000 32 13 32 7 8 6 3 9 6 0 0.144 0.653 1.000 224 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CD4(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), STAT4(2), TYK2(5) 4809186 16 6 16 5 6 2 1 5 2 0 0.484 0.656 1.000 225 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(4), CR2(3), HLA-DRA(2), ICAM1(2), ITGAL(1), ITGB2(1), PTPRC(4) 4970171 17 11 17 5 6 4 0 4 3 0 0.320 0.657 1.000 226 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), CFL1(1), FLNA(8), FLNC(7), FSCN1(2), FSCN2(1), FSCN3(1), GDI1(3), LIMK1(2), MYH2(9), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), ROCK1(2), ROCK2(2), RPS4X(2), WASF1(1), WASL(1) 15637648 60 22 60 17 21 9 8 15 6 1 0.0982 0.667 1.000 227 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), GFPT1(1), GNE(1), GNPDA1(2), HEXA(1), HK1(3), HK2(2), HK3(1), RENBP(1) 5548225 14 7 14 4 3 4 3 3 1 0 0.389 0.670 1.000 228 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), GNAS(3), PLCE1(6), PRKACG(1), PRKAR1A(1), RAP2B(1) 4805367 14 9 14 4 4 3 1 2 4 0 0.501 0.675 1.000 229 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), UGDH(1), UGP2(1), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1) 8935182 29 17 28 9 5 2 8 13 1 0 0.429 0.687 1.000 230 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(1) 2136972 3 3 3 0 0 1 0 2 0 0 0.357 0.688 1.000 231 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(1) 2136972 3 3 3 0 0 1 0 2 0 0 0.357 0.688 1.000 232 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(1), HLA-DRA(2), PTPRC(4), ZAP70(3) 2955188 12 6 12 2 4 3 0 5 0 0 0.232 0.688 1.000 233 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), BLNK(2), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(4), RAC1(1), RPS6KA1(2), RPS6KA3(2), SHC1(1), SOS1(1), VAV1(4), VAV2(1), VAV3(5) 10477468 35 16 33 9 6 6 1 13 8 1 0.262 0.689 1.000 234 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3D(1), CD4(1) 1052589 3 2 3 2 1 1 0 1 0 0 0.811 0.697 1.000 235 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(3), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), CAD(4), CRAT(1), GAD1(2), GAD2(1), GOT1(2), PC(1) 8520098 24 10 24 2 7 6 0 7 4 0 0.0115 0.697 1.000 236 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCA(1), SNCAIP(1) 2106098 4 3 4 2 3 0 0 1 0 0 0.719 0.703 1.000 237 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), SEC22B(1), SNAP29(1), STX11(1), TSNARE1(4), USE1(1), VAMP3(1), VAMP4(1), VAMP8(1), VTI1A(1) 5457423 14 8 14 7 3 3 1 1 6 0 0.836 0.707 1.000 238 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(2) 1064742 3 3 3 2 1 0 0 1 1 0 0.802 0.707 1.000 239 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(1), GLUD1(3), OAT(1) 1800853 7 4 7 3 1 1 0 3 2 0 0.766 0.709 1.000 240 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(2), LPO(5), MPO(2), MTHFR(6), SHMT1(1), TPO(3) 3794168 22 8 22 5 8 7 1 4 2 0 0.0713 0.711 1.000 241 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(2) 1226956 3 2 3 0 1 0 0 2 0 0 0.423 0.716 1.000 242 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(2), EPX(2), LPO(5), MPO(2), PRDX1(1), SHMT1(1), TPO(3) 3858611 18 7 18 5 7 7 0 2 2 0 0.117 0.725 1.000 243 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 JAK2(3), JAK3(1), STAT1(2), STAT3(1), STAT5B(2), TYK2(5) 6016194 14 6 14 4 3 0 0 8 2 1 0.657 0.728 1.000 244 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1), RAB3A(1), RAB9A(1) 1382777 3 2 3 0 2 1 0 0 0 0 0.267 0.730 1.000 245 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), UBE2D3(2), UBE2M(1) 3440753 4 4 3 7 0 0 1 0 3 0 1.000 0.734 1.000 246 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 1276996 1 1 1 1 0 1 0 0 0 0 0.876 0.737 1.000 247 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), CRADD(1), DFFA(1), LMNA(2), LMNB2(2), MADD(1), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(9), RB1(4), RIPK1(1), SPTAN1(2), TRADD(1) 12602660 30 17 30 6 8 4 4 5 8 1 0.162 0.740 1.000 248 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT3(1), AGPS(2), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GNPAT(1), LGALS13(2), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(1), PLCG1(6), PLCG2(7), PPAP2A(2), PPAP2C(1) 16311727 59 29 58 15 21 11 6 12 9 0 0.0890 0.740 1.000 249 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1) 15987288 55 23 55 11 20 12 5 12 6 0 0.00961 0.741 1.000 250 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1) 15987288 55 23 55 11 20 12 5 12 6 0 0.00961 0.741 1.000 251 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(2), PLCB2(1) 3634847 10 8 10 4 3 3 0 2 2 0 0.630 0.745 1.000 252 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(3), CCKBR(3), CELSR1(8), CELSR2(9), CELSR3(9), CHRM3(2), EMR2(2), EMR3(1), FSHR(2), GHRHR(2), GNRHR(2), GPR116(5), GPR132(3), GPR133(2), GPR143(3), GPR61(2), GPR77(1), GPR84(2), GRM1(4), GRPR(2), HRH4(1), LPHN2(5), LPHN3(3), LTB4R2(1), NTSR1(1), OR8G2(1), P2RY13(1), PTGFR(5), SMO(2), SSTR2(1), TAAR5(1), TSHR(4) 21771288 95 35 95 29 31 20 11 22 11 0 0.0604 0.748 1.000 253 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(2), CASP1(1), INSR(3), MAGI1(2), MAGI2(4), RERE(7), WWP1(3) 7834218 25 11 25 7 9 6 1 5 4 0 0.300 0.752 1.000 254 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(1), NFS1(3), THTPA(2) 2097971 9 2 9 2 1 3 0 4 1 0 0.514 0.754 1.000 255 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(2), ARSE(2), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(1), UGCG(2) 7906066 29 12 28 6 10 3 1 9 6 0 0.186 0.756 1.000 256 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), LPA(5), PLAT(1), PLAU(1), PLG(3), SERPINB2(1), SERPINE1(1), SERPINF2(1), VWF(5) 11540807 47 17 47 11 13 6 6 13 9 0 0.0867 0.758 1.000 257 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(3), PRKAR1A(1) 2137362 5 5 5 2 1 0 0 2 2 0 0.796 0.765 1.000 258 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(2) 1300108 4 3 4 2 1 0 0 3 0 0 0.800 0.769 1.000 259 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(1), GCK(1), GOT1(2), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PFKL(2), PGAM1(1), PGAM2(1), PKLR(1), TNFAIP1(2), TPI1(1) 13904346 42 17 42 3 15 14 3 7 3 0 4.55e-05 0.774 1.000 260 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(2), GALNT4(2), GALNT6(2), GALNT8(1), GALNT9(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(4) 4727482 16 6 16 4 7 4 0 4 1 0 0.259 0.780 1.000 261 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(1) 538884 3 1 3 0 0 3 0 0 0 0 0.291 0.781 1.000 262 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(3), DDC(1), GAD1(2), GAD2(1), HDC(2), PAH(1), TH(1), TPH1(2) 4695216 16 7 16 6 7 5 0 2 2 0 0.417 0.785 1.000 263 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(6), CAPNS1(1), CAPNS2(1), EP300(3), HDAC2(5), NFATC1(1), NFATC2(4), PPP3CA(1), PPP3CC(1), PRKCA(3) 7974021 26 10 26 8 7 3 4 5 6 1 0.516 0.786 1.000 264 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), IL3RA(2), JAK2(3), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2) 5777052 12 6 12 3 2 0 0 5 4 1 0.499 0.787 1.000 265 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB11(1), ABCB4(4), ABCC1(4), ABCC3(5) 4691159 17 6 17 4 4 2 3 5 2 1 0.290 0.787 1.000 266 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2B(2), ENPP1(1), ENPP3(2), G6PC(3), GAA(5), GANAB(2), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), MGAM(4), PYGB(1), PYGL(3), PYGM(1), SI(6), UCHL3(1), UGDH(1), UGT1A1(6), UGT2B15(1), UGT2B4(2), UXS1(2) 18613303 59 30 59 14 17 11 10 15 6 0 0.0553 0.787 1.000 267 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(4) 2758159 5 3 5 0 1 1 1 1 1 0 0.168 0.790 1.000 268 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(2), HSD17B4(2), MECR(1), PPT2(2) 2770585 9 5 9 5 2 1 0 2 4 0 0.874 0.791 1.000 269 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(3), HK2(2), HK3(1), ISYNA1(2), TGDS(1) 3818082 10 5 10 2 3 4 2 1 0 0 0.183 0.792 1.000 270 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), LARS(3), PDHA1(2), PDHA2(4) 3284254 10 5 10 3 1 2 2 2 3 0 0.538 0.793 1.000 271 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1) 2276418 8 3 8 4 0 0 1 4 3 0 0.908 0.793 1.000 272 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(1), CBR3(1), CYP4F3(4), EPX(2), GGT1(4), LPO(5), LTA4H(3), MPO(2), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TPO(3) 9125763 42 24 42 12 11 10 5 9 7 0 0.121 0.794 1.000 273 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(2), OXCT1(1) 2343265 7 2 7 0 1 3 0 3 0 0 0.119 0.798 1.000 274 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(6), PRKCA(3) 2203308 12 8 11 6 5 2 2 1 1 1 0.769 0.799 1.000 275 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(3), CBS(3), CTH(1), MUT(1) 1603537 8 2 8 0 2 5 0 1 0 0 0.0468 0.799 1.000 276 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(3), EPRS(2), GUSB(2), HCCS(3), UGT1A1(6), UGT2B15(1), UGT2B4(2), UROS(1) 8961250 24 13 24 5 6 1 8 9 0 0 0.166 0.800 1.000 277 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(3) 1007612 3 1 3 2 0 1 0 1 1 0 0.838 0.803 1.000 278 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(3), GTF2F1(2), GTF2H1(1), GTF2IRD1(2), TAF1(6), TAF1L(1), TAF2(1), TAF4(2), TAF4B(3), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(1), TAF9(2), TAF9B(1), TBPL1(1) 11771842 30 12 30 5 6 8 3 8 4 1 0.0554 0.804 1.000 279 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(2), IFNB1(1), STAT1(2), TYK2(5) 3540963 10 4 10 3 2 0 1 5 1 1 0.697 0.806 1.000 280 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NQO2(1), SQLE(1) 3607507 9 3 9 4 3 1 3 1 1 0 0.586 0.810 1.000 281 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAX(1), BCL2L11(1), CASP8AP2(2), CES1(1) 3516106 6 3 6 0 1 2 0 1 2 0 0.181 0.812 1.000 282 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), FH(1), IDH2(8), IDH3B(1), PC(1), PDHA1(2), PDHA2(4), PDK1(2), PDK3(3), PDK4(1), PDP2(1), SDHA(1), SDHC(1), SUCLG2(1) 9272371 29 17 23 9 3 10 4 8 4 0 0.281 0.816 1.000 283 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1) 1546128 1 1 1 0 0 0 0 0 1 0 0.719 0.818 1.000 284 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(9), C5(4), C6(2), C7(4), C8A(1) 4102799 20 10 20 8 5 2 3 5 5 0 0.600 0.826 1.000 285 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(1), CPO(1), HBA2(1), UROS(1) 2575668 6 2 6 1 3 0 0 2 1 0 0.393 0.832 1.000 286 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(8), EP300(3), ESR1(1), MAPK1(1), MAPK3(1), PELP1(1) 4819147 15 4 15 4 5 1 0 5 3 1 0.443 0.833 1.000 287 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(1), PLCB1(2), PRKCA(3), RELA(1) 2691881 8 5 8 5 2 0 1 3 1 1 0.870 0.833 1.000 288 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), RAC1(1), WASF1(1), WASL(1) 2658707 7 2 7 1 0 1 1 4 1 0 0.365 0.835 1.000 289 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ECHS1(2), EHHADH(1) 3977369 16 9 16 7 8 2 1 1 4 0 0.521 0.840 1.000 290 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CD4(1), HLA-DRA(2), IL1B(1), IL5RA(1), IL6(1) 1747785 7 3 7 2 0 0 0 7 0 0 0.710 0.841 1.000 291 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(3), HK2(2), HK3(1), TGDS(1) 3346466 8 4 8 2 3 3 2 0 0 0 0.296 0.842 1.000 292 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), NAGLU(2), SPAM1(1) 6699207 19 8 19 5 7 1 4 3 4 0 0.423 0.843 1.000 293 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK2(3), PTPRU(2), REG1A(1), STAT1(2) 3734110 9 5 9 4 2 1 0 2 3 1 0.743 0.844 1.000 294 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(3), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(1) 4996404 13 7 13 4 3 0 0 6 4 0 0.746 0.848 1.000 295 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), CEL(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GK(1), GLA(1), GLB1(1), LCT(5), LIPC(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(3), PPAP2A(2), PPAP2C(1) 15748464 57 20 57 15 22 6 9 13 7 0 0.0719 0.848 1.000 296 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(2), HDC(2), TH(1), TPH1(2) 1972646 7 3 7 2 4 2 0 1 0 0 0.349 0.849 1.000 297 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKACG(1), PRKAG1(1) 3297900 7 3 7 1 1 0 0 4 2 0 0.487 0.850 1.000 298 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(1), GCDH(1) 2549570 6 3 6 5 1 1 0 2 2 0 0.932 0.856 1.000 299 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT3(1), CHPF(1), CHST11(1), CHST13(1), CHST3(2), CHSY1(1), DSE(1), XYLT1(1), XYLT2(1) 4549569 10 6 10 2 3 1 0 6 0 0 0.349 0.857 1.000 300 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 RIPK1(1), TNFRSF1B(2), TRADD(1) 2735438 4 3 4 2 2 0 0 0 2 0 0.775 0.859 1.000 301 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AGK(1), AGPAT3(1), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CEL(1), DAK(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GK(1), GK2(3), GLA(1), GLB1(1), GPAM(1), LCT(5), LIPA(2), LIPC(1), LIPG(2), LPL(2), MGLL(1), PNLIP(1), PNLIPRP1(3), PNPLA3(1), PPAP2A(2), PPAP2C(1) 19181957 69 23 69 16 26 6 12 17 8 0 0.0279 0.860 1.000 302 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ARAF(1), ATF4(1), BRAF(3), CACNA1C(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CREBBP(8), EP300(3), GRIA1(4), GRIA2(2), GRIN2A(2), GRIN2B(4), GRIN2C(3), GRIN2D(4), GRM1(4), GRM5(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), RAF1(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2) 32509929 98 38 98 25 25 10 12 30 19 2 0.0725 0.861 1.000 303 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(5), MPI(1), PYGL(3), PYGM(1), TPI1(1), TREH(1) 4388226 15 6 15 4 4 4 2 1 4 0 0.273 0.862 1.000 304 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FHL5(1), FSHR(2), GNAS(3), XPO1(1) 3107805 8 7 8 3 1 1 1 3 2 0 0.771 0.869 1.000 305 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(2), ACAT2(1), ECHS1(2), EHHADH(1) 2732852 6 4 6 7 1 1 0 1 3 0 0.986 0.869 1.000 306 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS2(2), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(3), INPP5B(2), INPP5D(2), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPR1(2), ITPR2(11), ITPR3(6), OCRL(4), PI4KA(5), PI4KB(1), PIK3C2A(3), PIK3C2G(1), PIK3C3(2), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(2), PIP5K1C(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(7), PLCZ1(3), PRKCA(3), PRKCG(1), PTEN(13), SYNJ1(4), SYNJ2(7) 40713314 171 75 161 36 41 30 25 38 36 1 0.00253 0.871 1.000 307 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(3), AGT(2), AGTR2(1), ANPEP(2), CMA1(2), CTSG(1), ENPEP(4), LNPEP(1), MME(2), REN(1), THOP1(3) 6931932 24 10 24 4 7 5 1 7 4 0 0.0724 0.871 1.000 308 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), GNAI1(1), GNAS(3), MAPK1(1), MAPK3(1), MYT1(3), PRKACG(1), PRKAR1A(1), RPS6KA1(2) 6691715 14 10 14 9 1 0 0 4 8 1 0.963 0.876 1.000 309 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(1), CHST13(1), SULT2A1(1), SULT2B1(2), SUOX(1) 2995273 7 3 7 3 0 1 0 5 1 0 0.814 0.877 1.000 310 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(1), GUSB(2), HEXA(1), IDS(1), LCT(5), NAGLU(2) 4701953 12 5 12 4 6 1 2 1 2 0 0.555 0.879 1.000 311 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(3), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), G6PC2(1), GALM(1), GAPDHS(1), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PFKL(2), PGAM1(1), PGAM2(1), PKLR(1), TPI1(1) 19041582 67 26 67 10 25 12 6 16 8 0 0.000423 0.880 1.000 312 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(8), EP300(3), LPL(2), NCOA1(1), PPARG(1), RXRA(1) 6036117 16 8 16 5 3 3 0 8 2 0 0.592 0.880 1.000 313 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 2682816 6 2 6 3 1 2 0 0 2 1 0.521 0.883 1.000 314 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), MAPK1(1), MAPK8(1), PRKCA(3) 2888684 6 2 6 1 1 1 1 0 2 1 0.221 0.884 1.000 315 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(1), IL6(1), IL9(1) 1947293 3 2 3 1 0 0 0 2 1 0 0.803 0.884 1.000 316 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD4(1), IL6(1), KITLG(2) 2019579 5 2 5 1 0 1 1 3 0 0 0.522 0.887 1.000 317 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), MAP2(4), PRKACG(1), PRKAG1(1) 5944506 11 5 11 3 1 2 1 4 3 0 0.562 0.888 1.000 318 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BAX(1), BIRC2(1), CYCS(2), DFFA(1), DIABLO(1) 4386978 7 3 7 1 1 2 0 3 1 0 0.323 0.892 1.000 319 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CSK(1), PRKCA(3), PTPRA(4) 3016988 9 2 9 3 3 2 2 1 0 1 0.500 0.893 1.000 320 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(1), BRAF(3), CREB1(1), MAPK1(1), RAF1(1), SNX13(1) 3647303 8 3 8 2 1 0 2 2 3 0 0.412 0.893 1.000 321 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), PTPRU(2), REG1A(1), STAT1(2), TYK2(5) 4087799 11 6 11 4 2 1 1 3 3 1 0.705 0.894 1.000 322 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST3GAL4(1), ST6GALNAC4(1) 1852581 3 3 3 3 2 0 0 0 1 0 0.946 0.895 1.000 323 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(2), AXIN1(1), BTRC(1), CCND1(1), CREBBP(8), CSNK1A1(2), CSNK1D(1), CSNK2A1(2), CTBP1(3), FZD1(1), NLK(1), WIF1(2) 9590894 25 8 25 5 5 4 2 9 5 0 0.170 0.896 1.000 324 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(1), RECK(2), TIMP3(1), TIMP4(1) 2462085 5 2 5 2 1 2 1 0 1 0 0.610 0.898 1.000 325 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(2), ARSE(2), B4GALT6(1), DEGS1(2), DEGS2(1), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(1), SMPD2(1), SMPD3(2), SPTLC1(2), SPTLC2(1), UGCG(2) 11655704 39 14 38 8 13 4 2 14 6 0 0.103 0.900 1.000 326 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1), VAV1(4) 12495234 39 15 38 10 13 6 3 9 6 2 0.135 0.900 1.000 327 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(1), FARS2(2), GOT1(2), PAH(1), TAT(1), YARS(1) 2719843 11 4 11 3 5 2 1 1 2 0 0.446 0.900 1.000 328 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), FH(1), IDH2(8), SDHA(1) 3075492 12 10 6 5 2 6 1 2 1 0 0.521 0.901 1.000 329 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), MAPK3(1), POLR2A(3), PRKACG(1), PRKAR1A(1) 4210359 7 4 7 2 1 0 0 3 2 1 0.652 0.904 1.000 330 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1) 5394351 15 10 15 5 4 2 2 4 3 0 0.666 0.905 1.000 331 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CYCS(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(1), SMPD1(1), TRADD(1) 6707373 15 8 15 7 4 2 0 3 5 1 0.749 0.907 1.000 332 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(2), AGTR2(1), CMA1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A5(3), COL4A6(5), REN(1) 8257680 24 10 24 8 7 9 1 3 3 1 0.416 0.909 1.000 333 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASDHPPT(1) 2277318 3 2 3 0 0 0 1 1 1 0 0.384 0.910 1.000 334 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PFKL(2), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2), TKTL2(1) 7940739 23 11 23 7 11 7 0 2 3 0 0.151 0.911 1.000 335 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), JAK2(3), JAK3(1), PIAS3(1), PTPRU(2), REG1A(1), STAT3(1) 4984696 11 8 11 4 2 1 0 5 3 0 0.658 0.914 1.000 336 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 FBP2(2), G6PC(3), GAA(5), GANAB(2), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4) 10655193 30 14 30 9 17 4 2 5 2 0 0.252 0.915 1.000 337 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), GOT1(2), PAH(1), TAT(1), YARS(1) 2847929 7 4 7 3 2 2 1 1 1 0 0.736 0.916 1.000 338 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1B2(2), EEF1D(3), EEF2(1), EEF2K(1), EIF1AX(3), EIF2AK3(2), EIF2B4(1), EIF4A1(3), EIF4A2(1), EIF4E(1), EIF4G1(3), EIF4G3(4), GSPT2(4), KIAA0664(4), PABPC1(4), PABPC3(2), PAIP1(1) 14319867 41 27 40 10 9 6 6 10 10 0 0.222 0.917 1.000 339 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(2), EHHADH(1), HSD17B4(2), SIRT7(1) 3873594 8 4 8 5 2 0 1 2 3 0 0.906 0.917 1.000 340 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(2), GLB1(1), HEXA(1), LCT(5), SLC33A1(2), ST3GAL1(1), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3) 5392115 18 9 18 7 9 1 1 1 6 0 0.768 0.918 1.000 341 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TPI1(1) 5898973 12 5 12 2 5 2 1 2 2 0 0.213 0.922 1.000 342 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(1), SHH(1), XPO1(1) 2835325 5 3 5 3 1 4 0 0 0 0 0.752 0.923 1.000 343 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), IARS2(2), ILVBL(3), LARS(3), PDHA1(2), PDHA2(4), VARS(3), VARS2(1) 6079186 19 7 19 5 3 4 2 6 4 0 0.431 0.925 1.000 344 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(4), PER2(3), PER3(1) 5577406 16 6 16 5 2 4 1 7 2 0 0.628 0.926 1.000 345 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(1), ARHGDIB(1), CASP1(1), CASP10(1), CYCS(2), PRF1(1) 4209081 8 4 8 4 1 4 0 3 0 0 0.750 0.928 1.000 346 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(2), ALG6(3), DAD1(1), DHDDS(1), DPAGT1(1), DPM1(2), FUT8(3), GANAB(2), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(2), RPN2(1), ST6GAL1(1), STT3B(1) 13833237 43 17 43 11 9 9 7 7 11 0 0.222 0.928 1.000 347 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 4928004 7 3 7 1 2 4 0 0 0 1 0.221 0.929 1.000 348 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 4928004 7 3 7 1 2 4 0 0 0 1 0.221 0.929 1.000 349 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 4928004 7 3 7 1 2 4 0 0 0 1 0.221 0.929 1.000 350 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(5), EPHB1(1), FYN(1), ITGA1(2), ITGB1(2), L1CAM(4), SELP(2) 5164763 17 5 17 5 5 3 2 6 1 0 0.373 0.930 1.000 351 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA2(2), ACADM(1), ACADS(1), ACAT2(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), ALDH7A1(2), AOX1(3), BCKDHA(1), DBT(2), ECHS1(2), EHHADH(1), HIBADH(1), HIBCH(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2) 14064956 48 18 47 13 17 11 3 8 9 0 0.157 0.930 1.000 352 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), EGFR(13), ELK1(3), MAP2K2(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(3), PTK2(1), RAC1(1), RAF1(1), SHC1(1), SOS1(1) 10952706 37 16 34 11 6 8 1 11 9 2 0.324 0.930 1.000 353 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 HSD11B1(1) 2262904 1 1 1 1 1 0 0 0 0 0 0.848 0.930 1.000 354 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(2), RPL10L(1), RPL13A(1), RPL18A(1), RPL29(1), RPL32(1), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(1), RPS3(1), RPSA(2) 7355295 18 7 18 2 7 2 3 4 2 0 0.124 0.933 1.000 355 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(2), DAG1(1), DLG4(3), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RYR1(9) 14959075 46 16 46 11 12 6 9 11 8 0 0.0940 0.934 1.000 356 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), PNPLA3(1), SH3GLB1(3) 8162661 24 8 23 6 7 3 1 11 2 0 0.360 0.934 1.000 357 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC1(2), APOBEC3F(1), APOBEC4(2) 2397289 7 5 7 4 1 1 0 4 1 0 0.881 0.935 1.000 358 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1), GREB1(5), MTA3(2) 3562644 8 3 8 1 5 0 1 2 0 0 0.191 0.939 1.000 359 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(3), CTH(1), GGT1(4), LCMT1(2), LCMT2(1), MARS(4), MARS2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SCLY(2) 8161124 26 8 26 4 5 7 4 9 1 0 0.0343 0.939 1.000 360 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(1), CASP10(1), CASP4(1), CYCS(2), DFFA(1), LMNA(2), LMNB2(2), PRF1(1) 6310337 14 5 14 4 3 5 1 4 1 0 0.379 0.942 1.000 361 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 HSD17B2(1), HSD17B4(2) 2649945 3 3 3 4 1 0 0 1 1 0 0.986 0.947 1.000 362 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), FDXR(1), SHMT1(1) 5244576 8 3 8 1 3 4 0 0 0 1 0.165 0.948 1.000 363 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 FLT3(2), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1) 2657254 9 3 9 3 2 1 1 3 2 0 0.579 0.950 1.000 364 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPOR(1), JAK2(3), NFKB1(1), NFKBIA(1), RELA(1), SOD2(1) 4135148 8 3 8 5 2 1 0 3 2 0 0.866 0.950 1.000 365 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), ICAM1(2), ITGAL(1), ITGB2(1), PTPRC(4) 3521477 10 7 10 5 4 4 0 1 1 0 0.617 0.951 1.000 366 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(2), FCGR3A(1), IL1B(1), SPN(1), TGFB2(2), TNFRSF1B(2), TNFRSF8(1), TNFSF8(1) 4273265 13 5 13 4 5 3 1 2 2 0 0.349 0.951 1.000 367 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCK1(1), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB3(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1) 17153168 46 15 46 13 15 6 10 10 4 1 0.144 0.953 1.000 368 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCK1(1), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB3(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1) 17153168 46 15 46 13 15 6 10 10 4 1 0.144 0.953 1.000 369 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(1), PTPRC(4) 3692971 11 7 11 5 4 4 0 2 1 0 0.587 0.954 1.000 370 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TKTL2(1), TPI1(1) 6596962 13 6 13 2 5 2 1 3 2 0 0.183 0.955 1.000 371 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1) 2512805 6 2 6 4 1 2 0 0 3 0 0.937 0.955 1.000 372 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PLCB1(2), PRKCA(3), RAF1(1), RELA(1) 5073779 11 6 11 6 2 0 1 3 3 2 0.747 0.956 1.000 373 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), OAT(1), ODC1(2), SMS(1) 5728120 18 6 18 5 3 4 0 3 8 0 0.476 0.957 1.000 374 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL6(1), STAT1(2), STAT3(1) 3980292 6 3 6 3 2 0 0 3 0 1 0.839 0.957 1.000 375 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACSL1(3), ACSL3(2), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1), SCP2(1), SLC25A20(1) 5504660 15 6 15 6 0 5 0 4 6 0 0.700 0.958 1.000 376 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), AR(3), ESR1(1), ESR2(3), ESRRA(2), HNF4A(1), NPM1(2), NR1D1(1), NR1D2(1), NR1H2(1), NR1H3(4), NR1I2(1), NR2C2(1), NR2E1(1), NR2F2(1), NR3C1(2), NR4A1(1), NR4A2(1), NR5A1(1), PGR(2), PPARA(2), PPARG(1), ROR1(2), RXRA(1), RXRG(3), VDR(1) 13724367 41 13 40 10 14 7 6 10 4 0 0.0920 0.960 1.000 377 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA1B(2), ADRB2(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), DRD3(1), DRD5(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1) 8363588 30 15 30 10 9 4 4 6 7 0 0.305 0.960 1.000 378 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), PNPLA3(1), SH3GLB1(3) 5407039 10 3 9 1 5 2 0 2 1 0 0.161 0.961 1.000 379 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(3), ST3GAL1(1), ST3GAL4(1) 2565737 5 4 5 3 2 2 0 0 1 0 0.829 0.961 1.000 380 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK2(3), JAK3(1), PIAS1(1), PIAS3(1), PTPRU(2), REG1A(1), SOAT1(1) 4479069 11 8 11 7 2 1 0 5 3 0 0.937 0.962 1.000 381 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12B(2), ALOX15(1), CBR3(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2U1(1), CYP4A11(1), CYP4F3(4), EPHX2(2), GGT1(4), GPX1(2), GPX4(1), LTA4H(3), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS1(2), PTGS2(2) 12725384 47 31 46 13 12 7 7 12 9 0 0.239 0.963 1.000 382 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), BLNK(2), BTK(1), CARD11(1), CD22(1), CD81(1), CR2(3), IFITM1(1), INPP5D(2), KRAS(1), LILRB3(4), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NRAS(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PLCG2(7), PPP3CA(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(1), RASGRP3(1), VAV1(4), VAV2(1), VAV3(5) 24300376 102 50 91 29 28 17 12 18 27 0 0.134 0.965 1.000 383 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), CES1(1), CES2(1), UGT1A1(6) 7474823 12 6 12 4 3 2 3 3 1 0 0.505 0.966 1.000 384 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(2), DHRS3(1), DHRS7(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1) 4916153 15 3 14 3 6 2 1 5 1 0 0.176 0.968 1.000 385 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(3), CREBBP(8), EP300(3), MAPK3(1), SKIL(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2) 8394581 25 7 25 4 5 4 1 12 2 1 0.142 0.968 1.000 386 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLOCK(2), CRY1(2), EIF4G2(1), ETV6(2), HERPUD1(1), HSPA8(1), IDI1(1), NCKAP1(2), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), TUBB3(3), UGP2(1), ZFR(1) 11933393 35 12 35 7 5 9 6 11 4 0 0.117 0.969 1.000 387 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP7A(5), ATP7B(2), COX7A1(1), COX7B(1), NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1), SDHA(1), SHMT1(1), UQCRC1(2), UQCRH(2) 12489967 32 10 32 5 4 6 3 12 6 1 0.0553 0.973 1.000 388 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(6), ACTN3(1), BCAR1(1), CSK(1), CTNNA2(2), PTK2(1), VCL(1) 6264821 13 4 13 3 6 3 0 3 1 0 0.239 0.973 1.000 389 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(1), GNA11(1), GNAI1(1), JAK2(3), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MYLK(3), PLCG1(6), PRKCA(3), RAF1(1), SHC1(1), SOS1(1), STAT1(2), STAT3(1) 13618366 37 14 36 9 11 5 3 7 8 3 0.134 0.974 1.000 390 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), G6PC(3), G6PC2(1), GAA(5), GANC(3), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4), PFKL(2), UGP2(1) 12636199 35 13 35 10 19 4 2 7 3 0 0.224 0.975 1.000 391 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), MAPK8(1), PLCG1(6), PRKCA(3) 4506142 11 8 10 5 2 3 3 1 1 1 0.632 0.975 1.000 392 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOB(1), FBP1(1), FBP2(2), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), MPI(1), MTMR1(1), MTMR2(2), MTMR6(1), PFKFB1(3), PFKFB2(1), PFKFB3(2), PFKL(2), PGM2(5), SORD(1), TPI1(1), TSTA3(1) 12164345 35 12 35 7 15 9 2 4 5 0 0.0308 0.976 1.000 393 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOB(1), TPI1(1) 1282520 4 1 4 0 0 4 0 0 0 0 0.151 0.978 1.000 394 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), DPAGT1(1), DPM1(2), FUT8(3), MAN1A1(2), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), RPN2(1), ST6GAL1(1) 6492770 20 8 20 6 4 5 3 3 5 0 0.391 0.979 1.000 395 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), CEL(1), CYP27A1(1), CYP7A1(1), SOAT2(2), SRD5A1(1) 7590964 31 14 31 11 11 4 2 9 5 0 0.435 0.980 1.000 396 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GLA(1), HEXA(1), ST3GAL1(1), ST3GAL4(1) 3307389 6 3 6 5 3 0 0 2 1 0 0.978 0.980 1.000 397 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(2), FGA(4), FGB(1), PLAT(1), PLAU(1), PLG(3), SERPINB2(1), SERPINE1(1) 4384847 17 8 17 6 8 2 1 2 4 0 0.432 0.981 1.000 398 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(1), PRMT6(1) 4600473 12 2 12 3 3 2 1 5 1 0 0.353 0.981 1.000 399 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(9), C5(4), C6(2), C7(4), ICAM1(2), IL6(1), ITGA4(2), ITGAL(1), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), VCAM1(1) 8109986 32 17 32 12 8 5 5 8 6 0 0.455 0.981 1.000 400 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TOB1(1), TOB2(1) 3451115 10 4 10 2 3 3 1 3 0 0 0.254 0.982 1.000 401 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), FUT2(2), FUT5(2), FUT6(2), ST3GAL6(2) 5266985 16 9 16 7 5 1 3 5 2 0 0.768 0.983 1.000 402 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT2(2), GLA(1), HEXA(1), ST3GAL1(1) 3510574 6 2 6 6 3 0 0 2 1 0 0.990 0.983 1.000 403 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(2), CA1(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUL(1), HAL(1) 6216215 15 9 15 6 2 5 1 3 4 0 0.660 0.983 1.000 404 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CTH(1), GOT1(2), LDHB(1), SULT1B1(2), SULT1C2(3) 4102936 9 2 9 1 1 3 0 3 2 0 0.262 0.983 1.000 405 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(7), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(4), GPHN(1), NSF(2) 3905847 20 11 20 8 5 7 1 5 2 0 0.575 0.984 1.000 406 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(2), CES1(1), ESCO2(2), LIPA(2), PLA1A(2), PNPLA3(1), SH3GLB1(3) 8278529 13 4 13 4 3 3 2 3 2 0 0.488 0.985 1.000 407 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), FBP1(1), FBP2(2), GCK(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), MPI(1), PFKFB1(3), PFKFB3(2), SORD(1), TPI1(1) 7830685 21 7 21 4 8 8 1 2 2 0 0.0317 0.985 1.000 408 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1) 4185003 8 3 8 3 3 4 0 0 1 0 0.527 0.985 1.000 409 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(2), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), GCDH(1), ITGB1BP3(1), PNPLA3(1), SH3GLB1(3) 8476043 19 6 18 7 8 3 1 4 3 0 0.556 0.988 1.000 410 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(2), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1) 4145486 8 6 8 6 2 1 1 3 1 0 0.946 0.988 1.000 411 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1) 4383062 8 3 8 3 3 4 0 0 1 0 0.520 0.988 1.000 412 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(2), COL4A4(4), COL4A5(3), COL4A6(5), SLC23A2(3), SLC2A1(1), SLC2A3(2) 8195407 21 9 21 8 7 7 1 2 3 1 0.459 0.989 1.000 413 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(1), ALOX5AP(1), GGT1(4), LTA4H(3), PLA2G6(2), PTGS1(2), PTGS2(2) 4928859 15 8 15 6 2 5 3 3 2 0 0.592 0.989 1.000 414 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFAT5(3), PDE6B(3), PDE6C(6), SLC6A13(2), TF(1) 11705089 39 16 39 13 13 8 7 6 5 0 0.259 0.989 1.000 415 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CFL1(1), GNAS(3), LIMK1(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(1), PIK3C2G(1), PLCB1(2), PRKCA(3), PTK2(1), RAF1(1), ROCK2(2) 8186049 21 13 21 9 3 1 2 7 6 2 0.814 0.990 1.000 416 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(1) 5234270 10 2 10 3 2 3 1 3 1 0 0.524 0.990 1.000 417 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), MAPK8(1), STAT4(2), TYK2(5) 6100376 16 6 16 8 6 3 1 4 2 0 0.823 0.990 1.000 418 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), GNAI1(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), PLA2G4A(4), PLCB1(2), PRKCA(3), PTGS1(2), PTK2(1), RAF1(1) 7967874 22 13 22 9 2 1 4 8 5 2 0.726 0.991 1.000 419 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(2), CA1(1), CA13(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), HAL(1) 6949108 17 10 17 8 2 6 1 4 4 0 0.776 0.992 1.000 420 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(10), ACACB(5), FASN(1), MCAT(1), OXSM(1) 5167358 18 10 17 8 4 4 2 6 2 0 0.675 0.992 1.000 421 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 MAP3K1(2), MAP3K5(2), MAP4K5(1), MAPK8(1), NFKB1(1), NFKBIA(1), RELA(1), TNFRSF9(2) 6318123 11 7 11 5 4 2 2 1 2 0 0.682 0.992 1.000 422 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), MAF(1), MAP2K3(2), NFATC1(1), NFATC2(4), PRKACG(1), PRKAR1A(1) 3969455 11 6 11 6 6 1 0 3 1 0 0.783 0.993 1.000 423 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IRS1(2), JAK3(1), RPS6KB1(1), SHC1(1), STAT6(3) 4838413 9 5 9 4 2 2 0 4 1 0 0.725 0.993 1.000 424 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGW(1), PIGZ(1) 7785233 19 4 19 5 9 3 3 4 0 0 0.191 0.993 1.000 425 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(3), MARS(4), MARS2(1), MTR(2) 5698444 22 7 22 9 6 5 0 8 1 2 0.540 0.994 1.000 426 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), NCK1(1), NCKAP1(2), RAC1(1), WASF1(1), WASF3(2), WASL(1) 4995003 12 3 12 3 2 2 1 5 2 0 0.376 0.994 1.000 427 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPP(1), ALPP(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), PON1(3) 9546704 19 14 19 7 8 1 1 4 5 0 0.630 0.995 1.000 428 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD33(1), CD7(1), IFNB1(1), IL12B(2), TLR7(3), TLR9(1) 6078194 11 5 10 8 1 2 2 4 2 0 0.954 0.995 1.000 429 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), EPRS(2), FARS2(2), GARS(2), HARS(1), IARS(1), LARS(3), MARS(4), MARS2(1), QARS(1), RARS(2), WARS2(2), YARS(1) 10492055 23 7 23 6 4 7 1 8 3 0 0.361 0.995 1.000 430 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(1), AP2M1(1), BIN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(7) 7009110 19 6 19 5 6 2 2 4 5 0 0.331 0.995 1.000 431 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), CHST1(1), CHST4(1), FUT8(3), ST3GAL1(1), ST3GAL4(1) 4064224 8 6 8 7 3 3 1 0 1 0 0.947 0.995 1.000 432 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(2), AGPAT3(1), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), ESCO2(2), ETNK2(2), GNPAT(1), GPAM(1), PCYT1B(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(5), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(1), SH3GLB1(3) 21329299 52 17 52 14 17 12 5 10 8 0 0.0984 0.996 1.000 433 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), CRKL(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), PAK1(2), PLCG1(6), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1) 9316962 25 12 24 7 7 5 2 2 7 2 0.210 0.997 1.000 434 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(2), TRAF3(1) 7340558 13 6 13 7 6 1 1 1 4 0 0.772 0.997 1.000 435 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), TNFAIP3(1), TRAF3(1) 5930476 9 4 9 8 5 0 1 1 2 0 0.959 0.997 1.000 436 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(2), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HIBCH(1), MLYCD(3), SMS(1), SRM(1) 8826247 36 14 36 13 15 6 3 7 5 0 0.364 0.997 1.000 437 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA2(2), CNGA3(2), CNGB1(1), GNAL(1), PDE1C(5), PRKACG(1), PRKG1(1), PRKG2(1) 9969387 25 7 25 9 11 4 1 3 6 0 0.407 0.997 1.000 438 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), AOX1(3), BCKDHA(1), ECHS1(2), EHHADH(1), HIBADH(1), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2) 11775989 39 15 38 13 12 12 2 6 7 0 0.307 0.997 1.000 439 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), CASP10(1), DFFA(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(1) 5968998 9 3 9 4 2 3 1 3 0 0 0.674 0.998 1.000 440 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN2(6), ACTN3(1), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(1), RAC1(1), SPTAN1(2), TLN1(2) 9324741 21 6 21 6 6 2 4 5 4 0 0.349 0.998 1.000 441 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CRADD(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TANK(1), TRADD(1) 7883288 13 8 13 8 6 3 0 1 3 0 0.858 0.998 1.000 442 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(2), CD1A(2), CD1B(3), CD1E(3), CD22(1), CD33(1), CD36(3), CD3D(1), CD4(1), CD44(2), CD55(1), CD7(1), CR1(4), CR2(3), CSF1R(3), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(2), GP5(1), GP9(1), HLA-DRA(2), HLA-DRB5(3), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(2), IL5RA(1), IL6(1), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(3), KITLG(2), MME(2), MS4A1(2), TFRC(1), TPO(3) 26606506 84 26 84 25 18 20 8 25 13 0 0.110 0.998 1.000 443 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(2), ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CEL(1), CYP27A1(1), CYP7A1(1), LIPA(2), SLC27A5(3), SOAT1(1), SOAT2(2), SRD5A1(1) 10330337 45 17 45 16 15 5 3 15 7 0 0.527 0.998 1.000 444 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(2), SDHA(1), SDHC(1), UQCRC1(2) 2161567 6 3 6 2 0 1 2 3 0 0 0.625 0.998 1.000 445 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(2), LDHB(1) 2240265 4 1 4 1 1 2 0 1 0 0 0.531 0.998 1.000 446 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR3(1), MAP3K1(2), NFATC1(1), NFATC2(4), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), RELA(1) 9140842 21 12 20 9 7 2 1 7 4 0 0.780 0.998 1.000 447 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PRPS1L1(1), PRPS2(3), RBKS(1), TAL1(1), TALDO1(2), TKT(2) 6676944 21 9 21 8 9 7 0 1 4 0 0.271 0.998 1.000 448 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(1), GLI3(2), PRKACG(1), PRKAR1A(1), SHH(1), SMO(2), SUFU(1) 5438954 10 4 10 5 1 5 0 3 1 0 0.722 0.998 1.000 449 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(1), CMAS(1), GFPT1(1), GFPT2(3), GNE(1), GNPDA1(2), GNPNAT1(1), HEXA(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1), RENBP(1) 9387718 23 11 23 8 4 7 3 5 4 0 0.519 0.999 1.000 450 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(1), DHCR24(2), DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NSDHL(2), SQLE(1) 6290354 14 6 14 8 6 1 4 2 1 0 0.848 0.999 1.000 451 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATP6V0C(1), GART(3), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1) 5848674 18 3 18 8 5 6 2 3 1 1 0.585 0.999 1.000 452 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(1), UROS(1) 2487800 4 1 4 1 2 0 0 2 0 0 0.640 0.999 1.000 453 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY3(2), ADCY9(3), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ERO1L(1), GNAS(3), PLCG1(6), PLCG2(7), PRKCA(3), SEC61A1(1) 12073310 36 20 35 11 17 7 3 4 4 1 0.247 0.999 1.000 454 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), ELK1(3), IL2RB(1), JAK3(1), MAPK3(1), MAPK8(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2) 7623685 14 8 14 6 1 4 0 6 2 1 0.646 0.999 1.000 455 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), CREB1(1), DAG1(1), EPHB2(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1) 9348084 15 7 15 5 3 2 2 4 4 0 0.453 0.999 1.000 456 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), CASP10(1), CFLAR(1), CYCS(2), DFFA(1), GAS2(1), LMNA(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), SPTAN1(2), TRADD(1) 10903246 18 7 18 7 5 3 1 5 4 0 0.611 0.999 1.000 457 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(5), AOX1(3), DDC(1), ESCO2(2), GOT1(2), GSTZ1(2), HGD(3), HPD(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), SH3GLB1(3), TAT(1), TH(1), TPO(3), TYR(4), TYRP1(2) 19440047 60 19 60 20 19 8 6 20 7 0 0.331 0.999 1.000 458 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), CREB1(1), ELK1(3), GNAI1(1), GNAS(3), MAPK3(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), PRKCA(3), RAF1(1), RPS6KA3(2) 11392110 36 17 35 12 10 4 4 8 8 2 0.471 0.999 1.000 459 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1) 8870879 15 5 15 7 8 1 1 1 4 0 0.728 1.000 1.000 460 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(1), TOP2A(4), TOP2B(1) 2862465 6 1 6 3 3 1 1 0 1 0 0.767 1.000 1.000 461 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(1), AKT1(1), ARRB1(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(1), CACNA1B(7), CACNA1C(1), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CACNA2D1(2), CACNA2D2(1), CACNA2D3(1), CACNA2D4(2), CACNB2(3), CACNB3(1), CACNB4(1), CACNG1(2), CACNG2(1), CACNG3(2), CACNG7(3), CACNG8(1), CRKL(1), DAXX(2), DDIT3(1), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(2), DUSP7(1), DUSP9(2), EGF(3), EGFR(13), ELK1(3), FAS(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(2), FGFR4(3), FLNA(8), FLNB(7), FLNC(7), GNG12(1), IL1B(1), IL1R1(1), IL1R2(2), KRAS(1), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K8(2), MAP4K3(1), MAP4K4(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MRAS(1), NF1(20), NFATC2(4), NFATC4(3), NFKB1(1), NFKB2(1), NLK(1), NR4A1(1), NRAS(1), PAK1(2), PDGFA(1), PDGFRA(8), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PTPN5(1), PTPN7(1), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(3), RASA1(4), RASA2(2), RASGRF1(2), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RRAS(1), SOS1(1), SOS2(4), SRF(2), STK3(2), TAOK2(3), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TP53(154) 93268267 466 161 388 112 145 75 55 101 75 15 7.58e-07 1.000 1.000 462 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(5), AOX1(3), DDC(1), GOT1(2), GSTZ1(2), HGD(3), HPD(1), TAT(1), TH(1), TPO(3), TYR(4) 10371892 40 17 40 15 16 3 4 12 5 0 0.483 1.000 1.000 463 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(2), PPP3CA(1), PPP3CC(1), SLC2A4(1), YWHAH(1) 6611233 19 4 19 6 5 6 0 2 6 0 0.427 1.000 1.000 464 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), ARHGEF1(1), MYL2(1), MYLK(3), PLCB1(2), PRKCA(3), ROCK1(2) 6744538 13 5 13 6 5 1 3 2 1 1 0.670 1.000 1.000 465 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(4), CDK4(1), CDKN1B(1), CEBPB(1), DMC1(2), EGR1(1), ESR2(3), FSHR(2), GJA4(1), MLH1(4), MSH5(1), NCOR1(8), NR5A1(1), NRIP1(1), PGR(2), PRLR(1), SMPD1(1), VDR(1), ZP2(1) 11455712 37 13 37 12 9 7 2 12 6 1 0.532 1.000 1.000 466 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(1), FBXW7(1), ITK(1), LAT(1), MAPK1(1), NCK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PLCG1(6), PTPRC(4), RAF1(1), RASGRP2(2), RASGRP3(1), RASGRP4(1), SOS1(1), SOS2(4), VAV1(4), ZAP70(3) 18181796 55 20 54 15 17 11 4 11 12 0 0.148 1.000 1.000 467 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(2), EXTL1(2), EXTL3(1), HS6ST2(3), NDST1(2), NDST2(2), NDST3(2), NDST4(1) 6756766 18 10 18 8 8 1 3 5 1 0 0.723 1.000 1.000 468 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), CHRM1(1), CHRNA1(2), FLT1(3), FLT4(3), KDR(6), NOS3(5), PDE3A(2), PRKACG(1), PRKAR1A(1), PRKG1(1), PRKG2(1), RYR2(11), SLC7A1(1), TNNI1(1) 13209940 40 21 40 14 11 6 7 10 6 0 0.376 1.000 1.000 469 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(3), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVRL1(3), AMHR2(1), BMP4(2), BMP5(3), BMP6(1), CHRD(1), CREBBP(8), CUL1(1), DCN(1), E2F5(1), EP300(3), GDF5(1), GDF6(1), INHBA(1), INHBB(1), INHBE(1), LTBP1(4), MAPK1(1), MAPK3(1), NODAL(1), PITX2(3), PPP2CB(1), PPP2R2C(3), RBL1(2), RBL2(2), ROCK1(2), ROCK2(2), RPS6KB1(1), RPS6KB2(2), SMAD1(3), SMAD2(3), SMAD3(2), SMAD5(1), SMAD7(2), SMAD9(2), SMURF1(1), SMURF2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS1(1), THBS2(4), THBS3(2), THBS4(3) 32296175 93 26 93 26 30 14 11 26 11 1 0.0644 1.000 1.000 470 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), SHC1(1), SOS1(1) 2889427 3 2 3 2 0 0 0 1 2 0 0.854 1.000 1.000 471 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMB8(1) 2857245 7 1 7 1 2 1 1 3 0 0 0.328 1.000 1.000 472 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(1), EIF4E(1), FBL(1), LDHB(1), NCL(1) 2914310 7 1 7 2 2 2 1 1 1 0 0.402 1.000 1.000 473 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(3), GRIN2A(2), GRIN2B(4), GRIN2C(3), GRIN2D(4), NOS1(2), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), PRKCA(3) 8347480 25 15 25 10 8 4 2 6 4 1 0.572 1.000 1.000 474 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11B1(2), HSD11B1(1) 3012109 4 3 4 3 1 0 1 1 1 0 0.887 1.000 1.000 475 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11B1(2), HSD11B1(1) 3012109 4 3 4 3 1 0 1 1 1 0 0.887 1.000 1.000 476 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(2), AXIN1(1), BMP10(1), BMP4(2), BMP5(3), CHRD(1), FZD1(1), MYL2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2) 11869396 21 6 21 4 8 4 2 5 2 0 0.113 1.000 1.000 477 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(2), HSD11B1(1), HSD17B2(1), SRD5A1(1), SULT2A1(1), UGT1A1(6), UGT2B15(1), UGT2B4(2) 8939447 20 14 20 9 8 1 5 5 1 0 0.632 1.000 1.000 478 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR161(1), GPR171(1), GPR34(1) 3208136 5 1 5 7 0 1 1 1 2 0 0.985 1.000 1.000 479 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(1), F2(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), MYEF2(2), PLD1(5), PLD3(1), PTK2(1), RAF1(1), RASAL1(2), TEC(1), VAV1(4) 8962801 30 11 30 10 8 6 1 10 5 0 0.403 1.000 1.000 480 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(6), CAMK4(2), CEBPB(1), CNR1(1), CREBBP(8), CSNK2A1(2), CTLA4(1), EGR3(1), EP300(3), FCGR3A(1), GATA3(1), IFNB1(1), IL1B(1), IL6(1), ITK(1), KPNA5(2), MAPK8(1), MAPK9(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB2(1), NFKBIE(1), NUP214(2), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(4), RELA(1), RPL13A(1), SLA(2), SP3(2), TRPV6(3), VAV1(4), VAV2(1), VAV3(5) 29715003 87 27 85 27 20 23 4 23 17 0 0.200 1.000 1.000 481 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(1), BLVRA(2), COX15(1), CP(3), EARS2(2), EPRS(2), FTH1(3), GUSB(2), HCCS(3), MMAB(1), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROS(1) 13816303 48 23 47 15 12 5 12 18 1 0 0.324 1.000 1.000 482 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP4(1), ARHGAP5(1), ARHGEF1(1), ARHGEF11(1), ARPC1B(1), ARPC3(1), BAIAP2(2), CFL1(1), DIAPH1(3), GSN(1), LIMK1(2), MYL2(1), MYLK(3), OPHN1(2), ROCK1(2), TLN1(2), VCL(1) 14813083 28 12 28 9 7 3 3 11 4 0 0.415 1.000 1.000 483 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), CYCS(2), DAXX(2), FAS(1), MAPKAPK2(1), MAPKAPK3(1) 3705299 8 2 8 4 0 2 2 3 1 0 0.834 1.000 1.000 484 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(1), CREB1(1) 3783734 10 2 10 2 4 3 0 0 3 0 0.191 1.000 1.000 485 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(2), CANX(1), CD4(1), CIITA(1), CREB1(1), CTSB(1), HLA-A(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(3), HLA-E(1), HLA-F(1), HSP90AB1(1), IFI30(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), KIR2DL1(2), KLRC1(1), KLRC2(1), LGMN(1), RFX5(1), RFXANK(1) 15088707 36 16 36 13 6 5 6 12 7 0 0.613 1.000 1.000 486 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(13), ELK1(3), GNAS(3), IGF1R(3), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), PDGFRA(8), PTPRR(3), RAF1(1), RPS6KA1(2), SHC1(1), SOS1(1), STAT3(1) 10795895 45 28 42 16 6 9 4 14 11 1 0.607 1.000 1.000 487 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(3), ATP5B(1), ATP5G2(1), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), COX15(1), COX17(1), COX7A1(1), COX7B(1), COX7B2(1), NDUFA10(3), NDUFA9(3), NDUFB11(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(1), SDHA(1), SDHC(1), TCIRG1(1), UQCRC1(2), UQCRH(2) 18218904 46 14 46 15 9 9 5 14 8 1 0.424 1.000 1.000 488 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), MBTPS1(1), MBTPS2(2), SCAP(1), SREBF1(2), SREBF2(1) 3916853 8 2 8 3 0 2 2 4 0 0 0.632 1.000 1.000 489 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(2), EGF(3), EGFR(13), ETS1(3), HOXA7(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKBIA(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(1), RAF1(1), RELA(1), RIPK1(1), TNFRSF1B(2) 16042379 47 23 44 17 12 9 4 11 8 3 0.333 1.000 1.000 490 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(1), ARHGDIB(1), BIRC2(1), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(1), GSN(1), LMNA(2), LMNB2(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(6), PRKDC(9), PTK2(1), RASA1(4), RB1(4), RELA(1), RIPK1(1), SPTAN1(2), TNFRSF1B(2), TRADD(1) 22532800 56 25 56 16 15 7 8 13 12 1 0.261 1.000 1.000 491 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), RPN2(1) 4218635 8 2 8 4 2 2 1 2 1 0 0.813 1.000 1.000 492 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ATP6V0C(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), PLOD1(2), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(1) 12105981 36 11 36 13 16 6 3 4 7 0 0.238 1.000 1.000 493 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(3), DNMT1(3), MTNR1A(1), PTGER4(1), PTGFR(5), TBXA2R(1) 3646401 15 4 15 9 4 2 0 8 1 0 0.908 1.000 1.000 494 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), IMPDH1(2), POLB(1), POLD1(1), POLG(1), PRPS2(3), RRM1(3), SRM(1) 4058917 15 5 15 6 5 4 1 3 2 0 0.560 1.000 1.000 495 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(4), CANT1(3), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), NT5C(2), NT5E(1), NT5M(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(5), POLR3GL(1), PRIM1(1), PRIM2(2), RRM1(3), TK2(3), TXNRD2(2), UCK1(2), UMPS(1), UPP1(1), UPP2(2), UPRT(2) 26431402 81 33 80 25 19 14 7 29 12 0 0.273 1.000 1.000 496 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 FYN(1), RELN(6), VLDLR(1) 4586918 8 3 8 8 2 3 0 2 1 0 0.975 1.000 1.000 497 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), ACVR1B(2), ACVR1C(1), BAIAP2(2), CDH1(3), CREBBP(8), CSNK2A1(2), CTNNA2(2), CTNNA3(1), EGFR(13), EP300(3), ERBB2(1), FARP2(1), FER(1), FGFR1(1), FYN(1), IGF1R(3), INSR(3), IQGAP1(8), LMO7(4), MAPK1(1), MAPK3(1), MET(6), MLLT4(4), NLK(1), PARD3(1), PTPRB(5), PTPRF(3), PTPRJ(3), PTPRM(4), PVRL1(1), PVRL4(2), RAC1(1), RAC2(1), SMAD2(3), SMAD3(2), SORBS1(1), SSX2IP(1), TCF7L2(2), TGFBR1(1), TGFBR2(2), TJP1(4), VCL(1), WAS(2), WASF1(1), WASF3(2), WASL(1), YES1(2) 39167400 129 50 126 32 34 19 12 40 22 2 0.0160 1.000 1.000 498 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(1) 4748947 8 2 8 5 2 3 1 1 1 0 0.814 1.000 1.000 499 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1) 4409957 8 3 8 4 4 1 1 2 0 0 0.755 1.000 1.000 500 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN2(6), ACTN3(1), BCAR1(1), BCR(1), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), SOS1(1), TLN1(2), VCL(1) 15394246 31 8 31 11 10 5 4 7 4 1 0.440 1.000 1.000 501 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), ALDH1A3(3), ALDH3A1(5), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2S1(1), CYP3A7(1), EPHX1(3), GSTA4(1), GSTA5(3), GSTZ1(2), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1) 18745806 66 31 65 22 19 7 11 22 7 0 0.378 1.000 1.000 502 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(2), HSD11B1(1), HSD17B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SRD5A1(1), SULT2A1(1), SULT2B1(2), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1) 16427814 49 25 48 18 13 4 10 18 4 0 0.468 1.000 1.000 503 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALT2(1), B3GALT5(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT2(2), FUT5(2), FUT6(2), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL4(1), ST3GAL6(2), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3), UGCG(2) 15846047 47 17 47 16 18 6 5 12 6 0 0.408 1.000 1.000 504 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BRAF(3), CD244(1), FAS(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-A(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IFNGR2(1), ITGAL(1), ITGB2(1), KIR2DL1(2), KLRC1(1), KLRC2(1), KRAS(1), LAT(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(3), NCR2(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NRAS(1), PAK1(2), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PLCG1(6), PLCG2(7), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCA(3), PRKCG(1), PTPN11(6), RAC1(1), RAC2(1), RAF1(1), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(4), VAV2(1), VAV3(5), ZAP70(3) 37047622 153 73 140 41 33 21 26 32 39 2 0.0510 1.000 1.000 505 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(2), CLTA(1), COPA(2), GBF1(2), GPLD1(1) 5307445 9 3 9 4 2 2 1 2 2 0 0.700 1.000 1.000 506 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), CREB1(1), EP300(3), NOS3(5) 5556247 10 3 10 6 5 0 2 2 1 0 0.849 1.000 1.000 507 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1) 5436563 14 2 14 9 3 2 1 7 1 0 0.938 1.000 1.000 508 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), DARS2(2), EARS2(2), EPRS(2), FARS2(2), GARS(2), HARS(1), HARS2(1), IARS(1), IARS2(2), LARS(3), MARS(4), MARS2(1), MTFMT(1), NARS2(1), PARS2(1), QARS(1), RARS(2), RARS2(4), SARS2(2), TARS2(1), VARS(3), VARS2(1), WARS2(2), YARS(1) 17742852 44 11 44 13 6 12 5 15 6 0 0.371 1.000 1.000 509 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(2), CLK3(3), CLK4(1), COL2A1(4), CPSF1(2), CPSF3(1), CSTF1(1), CSTF2(1), CSTF3(3), DDIT3(1), DHX16(2), DHX38(3), DHX8(7), DHX9(3), DICER1(2), FUS(2), LOC440563(2), METTL3(2), NCBP1(1), NONO(1), PAPOLA(5), POLR2A(3), PRPF4(1), PRPF4B(2), PRPF8(6), PSKH1(1), PTBP1(1), RBM5(2), RNGTT(1), SF3A3(1), SF3B1(5), SF3B2(1), SNRPA(1), SNRPB2(1), SNRPD3(1), SNRPE(1), SNRPN(1), SPOP(2), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), U2AF1(2), U2AF2(2), XRN2(3) 34544345 93 34 92 23 28 17 7 25 16 0 0.143 1.000 1.000 510 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(2), BMP5(3), BMP6(1), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(1), GLI1(2), GLI2(1), GLI3(2), HHIP(2), LRP2(12), PRKACG(1), PTCH1(3), RAB23(1), SHH(1), SMO(2), SUFU(1), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1), ZIC2(2) 19881568 57 22 57 20 21 11 8 11 6 0 0.300 1.000 1.000 511 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), CANT1(3), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), NT5C(2), NT5E(1), NT5M(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), RRM1(3), TK2(3), UCK1(2), UMPS(1), UPP1(1) 18714446 52 17 52 18 15 11 3 18 5 0 0.458 1.000 1.000 512 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), BCAR1(1), CAPN10(3), CAPN11(3), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(3), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(1), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(2), MAPK4(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PIK3R2(1), PTK2(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK1(2), ROCK2(2), SDCCAG8(1), SEPP1(2), SHC1(1), SORBS1(1), SOS1(1), TLN1(2), TNS1(2), VAV2(1), VAV3(5), VCL(1) 43766312 114 35 112 30 34 17 13 28 22 0 0.0533 1.000 1.000 513 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACADM(1), ACOX1(1), ACOX2(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(1), ACSL6(1), ANGPTL4(1), APOA1(1), AQP7(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(1), CYP7A1(1), EHHADH(1), FABP7(1), FADS2(2), GK(1), GK2(3), HMGCS2(2), LPL(2), ME1(1), MMP1(1), NR1H3(4), PCK1(3), PPARA(2), PPARG(1), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A5(3), SORBS1(1), UBC(7) 21391658 70 29 67 25 14 16 9 24 7 0 0.403 1.000 1.000 514 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), CARD11(1), CBLB(1), CBLC(1), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FYN(1), ITK(1), KRAS(1), LAT(1), MAP3K14(1), MAP3K8(2), NCK1(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PDK1(2), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(1), PTPRC(4), SOS1(1), SOS2(4), TEC(1), VAV1(4), VAV2(1), VAV3(5), ZAP70(3) 33154995 125 57 113 34 29 22 16 24 33 1 0.102 1.000 1.000 515 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C3AR1(2), C4BPA(2), C4BPB(1), C5(4), C6(2), C7(4), C8A(1), C8B(2), CD46(2), CD55(1), CFD(1), CFH(7), CPB2(1), CR1(4), CR2(3), F13A1(2), F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), KNG1(1), MBL2(2), PLAT(1), PLAU(1), PLG(3), PROS1(1), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), VWF(5) 29570330 110 44 110 33 31 18 14 30 17 0 0.101 1.000 1.000 516 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ATF4(1), CACNA1C(1), CACNA1D(5), CACNA1F(4), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), EGFR(13), ELK1(3), GNA11(1), GNAS(3), GNRHR(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAP3K3(2), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLD1(5), PRKACG(1), PRKCA(3), RAF1(1), SOS1(1), SOS2(4) 41578377 137 56 134 37 47 22 16 28 22 2 0.0151 1.000 1.000 517 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), ARHGAP5(1), BCAR1(1), BIRC2(1), BRAF(3), CCND1(1), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(7), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A6(5), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(2), COL6A3(10), COL6A6(3), CRKL(1), DIAPH1(3), DOCK1(1), EGF(3), EGFR(13), ELK1(3), ERBB2(1), FARP2(1), FLNA(8), FLNB(7), FLNC(7), FLT1(3), FN1(2), FYN(1), HGF(2), IBSP(1), IGF1R(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KDR(6), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(9), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), MET(6), MYL2(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PARVA(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PRKCA(3), PRKCG(1), PTEN(13), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(3), RELN(6), ROCK1(2), ROCK2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TLN1(2), TLN2(4), TNC(3), TNN(7), TNR(4), TNXB(9), VAV1(4), VAV2(1), VAV3(5), VCL(1), VEGFA(2), VEGFB(1), VEGFC(2), VWF(5) 121292622 411 118 397 115 105 82 52 95 72 5 0.000727 1.000 1.000 518 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN2(6), ACTN3(1), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(1), ARHGEF4(3), ARHGEF6(3), ARPC1B(1), ARPC3(1), BAIAP2(2), BCAR1(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(5), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(1), EGF(3), EGFR(13), EZR(1), F2(2), FGD3(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(2), FGFR4(3), FN1(2), GIT1(1), GNG12(1), GSN(1), IQGAP1(8), IQGAP2(4), IQGAP3(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(1), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KRAS(1), LIMK1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MRAS(1), MYH10(4), MYH14(4), MYL2(1), MYLK(3), MYLK2(1), NCKAP1(2), NCKAP1L(3), NRAS(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PDGFA(1), PDGFRA(8), PFN3(1), PFN4(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(2), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(2), RRAS(1), SCIN(2), SOS1(1), SOS2(4), SSH2(1), SSH3(1), TIAM1(3), TIAM2(4), VAV1(4), VAV2(1), VAV3(5), VCL(1), WAS(2), WASF1(1), WASL(1) 90272579 295 104 281 83 56 52 43 73 68 3 0.0135 1.000 1.000 519 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY7(2), ADCY9(3), ADRA1A(1), ADRA1B(2), ADRB2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), AVPR1A(2), AVPR1B(1), CACNA1A(1), CACNA1B(7), CACNA1C(1), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CCKBR(3), CHRM1(1), CHRM3(2), CHRM5(4), CHRNA7(1), CYSLTR1(1), CYSLTR2(1), EDNRB(1), EGFR(13), ERBB2(1), ERBB3(2), ERBB4(4), GNA11(1), GNA14(1), GNAL(1), GNAS(3), GRIN2A(2), GRIN2C(3), GRIN2D(4), GRM1(4), GRM5(2), GRPR(2), HRH1(1), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), ITPR1(2), ITPR2(11), ITPR3(6), LTB4R2(1), MYLK(3), MYLK2(1), NOS1(2), NOS3(5), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRA(8), PHKA1(2), PHKA2(4), PHKG1(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(7), PLCZ1(3), PPID(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PTGER3(1), PTGFR(5), RYR1(9), RYR2(11), RYR3(8), SLC25A5(1), SLC25A6(1), SLC8A2(3), SLC8A3(2), TACR2(1), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(2) 87837108 302 103 297 98 94 56 34 66 50 2 0.0320 1.000 1.000 520 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), CHAD(1), COL11A1(5), COL11A2(4), COL17A1(2), COL1A1(2), COL1A2(7), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A6(5), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(2), COL6A3(10), COL6A6(3), DSC1(2), DSC2(1), DSC3(4), DSG1(2), DSG2(1), DSG3(2), DSG4(1), FN1(2), GJA1(4), GJA10(1), GJA3(1), GJA4(1), GJA8(1), GJB2(1), GJB6(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(2), KRT1(3), KRT12(1), KRT14(1), KRT15(1), KRT16(3), KRT17(2), KRT2(1), KRT20(2), KRT24(1), KRT25(1), KRT27(1), KRT28(2), KRT3(3), KRT31(1), KRT33A(4), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT39(2), KRT5(4), KRT6B(2), KRT6C(3), KRT7(1), KRT71(2), KRT73(1), KRT75(2), KRT76(1), KRT77(1), KRT78(1), KRT8(3), KRT83(3), KRT84(1), KRT86(2), KRT9(1), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(9), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), LMNA(2), LMNB2(2), NES(3), PRPH(1), RELN(6), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VIM(2), VWF(5) 81328014 256 90 254 87 92 59 22 54 27 2 0.0669 1.000 1.000 521 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(3), ADORA3(2), ADRA1A(1), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CALCR(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CNR1(1), CNR2(3), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD3(1), DRD5(2), EDNRB(1), F2(2), FPR1(1), FSHR(2), GABBR1(2), GABRA1(7), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(4), GABRB1(4), GABRB2(2), GABRB3(2), GABRD(2), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(1), GABRP(1), GABRQ(1), GABRR1(2), GALR1(1), GH1(1), GHR(2), GHRHR(2), GIPR(2), GLP2R(1), GLRA1(1), GLRB(2), GNRHR(2), GPR35(1), GPR50(2), GPR63(1), GPR83(2), GRIA1(4), GRIA2(2), GRIA3(5), GRIA4(2), GRID1(1), GRID2(3), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(4), GRIK5(2), GRIN2A(2), GRIN2B(4), GRIN2C(3), GRIN2D(4), GRIN3A(2), GRIN3B(1), GRM1(4), GRM2(3), GRM3(4), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(1), GRPR(2), HCRTR2(2), HRH1(1), HRH4(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LEPR(1), LTB4R(1), LTB4R2(1), MC3R(1), MC4R(3), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(1), NPY1R(3), NR3C1(2), NTSR1(1), OPRL1(1), OPRM1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(3), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(1), PPYR1(2), PRLR(1), PRSS1(1), PRSS3(1), PTGER3(1), PTGER4(1), PTGFR(5), PTH2R(1), RXFP1(2), RXFP2(1), SSTR2(1), SSTR3(2), SSTR4(5), TAAR5(1), TAAR6(1), TACR2(1), TBXA2R(1), TRHR(2), TSHR(4), UTS2R(1), VIPR1(1) 72397897 279 88 279 89 85 54 31 77 32 0 0.0112 1.000 1.000 522 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), AMOTL1(1), ASH1L(4), CASK(1), CDK4(1), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(2), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), HCLS1(1), INADL(4), JAM2(3), JAM3(2), KRAS(1), LLGL1(3), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(5), MLLT4(4), MPDZ(6), MRAS(1), MYH1(5), MYH10(4), MYH11(2), MYH13(5), MYH14(4), MYH15(5), MYH2(9), MYH3(6), MYH4(5), MYH6(2), MYH7(5), MYH7B(5), MYH8(7), MYL2(1), NRAS(1), OCLN(1), PARD3(1), PARD6A(1), PPM1J(2), PPP2CB(1), PPP2R2C(3), PPP2R3A(2), PPP2R4(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PTEN(13), RAB3B(1), RRAS(1), SPTAN1(2), SYMPK(2), TJAP1(1), TJP1(4), TJP2(1), TJP3(1), YES1(2) 63287132 197 76 197 67 64 30 26 51 24 2 0.177 1.000 1.000 523 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(10), ACACB(5), AKT1(1), ARAF(1), BRAF(3), CBLB(1), CBLC(1), CRKL(1), ELK1(3), EXOC7(1), FASN(1), FBP1(1), FBP2(2), FLOT1(1), FLOT2(1), G6PC(3), G6PC2(1), GCK(1), GYS1(1), INPP5D(2), INSR(3), IRS1(2), IRS2(1), IRS4(6), KRAS(1), LIPE(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PCK1(3), PDE3A(2), PFKL(2), PHKA1(2), PHKA2(4), PHKG1(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PKLR(1), PPP1CB(1), PPP1R3A(2), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKCI(1), PTPRF(3), PYGB(1), PYGL(3), PYGM(1), RAF1(1), RAPGEF1(3), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(1), SOS2(4), SREBF1(2), TSC1(2), TSC2(2) 52368850 167 69 156 54 36 30 21 44 33 3 0.240 1.000 1.000 524 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(3), ACVR1B(2), ACVR2A(1), AMHR2(1), CCL11(1), CCL20(1), CCL26(2), CCL27(1), CCL5(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(2), CSF1R(3), CSF2RA(3), CSF2RB(1), CSF3R(1), CX3CR1(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(4), EGF(3), EGFR(13), EPOR(1), FAS(1), FLT1(3), FLT3(2), FLT4(3), GDF5(1), GH1(1), GHR(2), HGF(2), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(1), IL17RA(1), IL18RAP(1), IL1B(1), IL1R1(1), IL1R2(2), IL1RAP(1), IL20RA(2), IL23A(1), IL23R(4), IL25(1), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), INHBA(1), INHBB(1), INHBE(1), KDR(6), KIT(3), KITLG(2), LEPR(1), LIFR(1), LTBR(2), MET(6), MPL(2), NGFR(1), OSMR(3), PDGFC(1), PDGFRA(8), PRLR(1), RELT(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF19(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(2), TNFSF14(1), TNFSF15(3), TNFSF8(1), TPO(3), VEGFA(2), VEGFB(1), VEGFC(2), XCL1(1) 57812716 197 68 194 71 48 46 30 44 29 0 0.186 1.000 1.000 525 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN2(6), ACTN3(1), ACTN4(2), ARHGAP5(1), BCAR1(1), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(2), CTNNA3(1), CXCR4(1), CYBB(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), ICAM1(2), ITGA4(2), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(1), ITK(1), JAM2(3), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(4), MMP9(1), MYL2(1), NCF1(1), NCF2(3), NOX1(1), NOX3(1), OCLN(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PLCG1(6), PLCG2(7), PRKCA(3), PRKCG(1), PTK2(1), PTPN11(6), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(2), SIPA1(2), TXK(1), VAV1(4), VAV2(1), VAV3(5), VCAM1(1), VCL(1) 40599884 154 68 141 49 41 27 21 33 31 1 0.148 1.000 1.000 526 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(5), EFNA1(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB3(1), EPHA2(2), EPHA3(3), EPHA4(5), EPHA5(2), EPHA6(1), EPHA7(4), EPHA8(2), EPHB1(1), EPHB2(1), EPHB3(1), EPHB4(1), EPHB6(3), FES(2), FYN(1), GNAI1(1), ITGB1(2), KRAS(1), L1CAM(4), LIMK1(2), LRRC4C(4), MAPK1(1), MAPK3(1), MET(6), NCK1(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NGEF(3), NRAS(1), NRP1(3), NTN4(1), NTNG1(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PLXNA1(7), PLXNA2(4), PLXNA3(5), PLXNB1(4), PLXNB2(5), PLXNB3(3), PLXNC1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC2(1), RASA1(4), RGS3(5), RHOD(1), RND1(1), ROBO1(3), ROBO2(5), ROBO3(2), ROCK1(2), ROCK2(2), SEMA3A(4), SEMA3B(1), SEMA3C(1), SEMA3D(2), SEMA3E(4), SEMA3F(2), SEMA4B(1), SEMA4D(2), SEMA4F(2), SEMA4G(1), SEMA6A(2), SEMA6B(3), SEMA6C(2), SEMA6D(2), SEMA7A(2), SLIT1(4), SLIT2(3), SLIT3(1), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(1) 64538174 214 65 214 72 61 38 28 56 30 1 0.120 1.000 1.000 527 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(3), CD44(2), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(7), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A6(5), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(2), COL6A3(10), COL6A6(3), DAG1(1), FN1(2), FNDC1(2), FNDC3A(3), FNDC5(1), GP5(1), GP9(1), HSPG2(8), IBSP(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(9), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), RELN(6), SDC1(1), SDC3(1), SPP1(1), SV2A(2), SV2B(2), SV2C(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VWF(5) 73172025 217 65 217 64 68 54 24 47 22 2 0.00850 1.000 1.000 528 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(1), CBLB(1), CBLC(1), CCND1(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(8), CRLF2(2), CSF2RA(3), CSF2RB(1), CSF3R(1), EP300(3), EPOR(1), GH1(1), GHR(2), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL20RA(2), IL23A(1), IL23R(4), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), IRF9(2), JAK2(3), JAK3(1), LEPR(1), LIFR(1), MPL(2), OSMR(3), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), PIM1(2), PRLR(1), PTPN11(6), SOCS4(1), SOS1(1), SOS2(4), SPRED1(1), SPRED2(2), SPRY1(1), SPRY4(1), STAM2(1), STAT1(2), STAT3(1), STAT4(2), STAT5B(2), STAT6(3), TPO(3), TYK2(5) 47456510 163 62 153 47 32 25 28 48 29 1 0.151 1.000 1.000 529 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADRA1A(1), ADRA1B(2), ADRB2(1), ANXA6(2), ARRB1(2), ATP1B2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), CACNA1A(1), CACNA1B(7), CACNA1C(1), CACNA1D(5), CACNA1E(5), CACNA1S(6), CACNB3(1), CALR(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CASQ1(2), CASQ2(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), GJA1(4), GJA4(1), GJB2(1), GJB6(1), GNA11(1), GNAO1(2), GNB5(1), GNG12(1), GRK4(4), GRK5(4), ITPR1(2), ITPR2(11), ITPR3(6), KCNB1(2), KCNJ3(1), KCNJ5(2), MIB1(1), PLCB3(3), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(1), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(1), RYR1(9), RYR2(11), RYR3(8), SLC8A3(2), YWHAH(1), YWHAQ(1) 61223447 187 59 186 64 64 32 20 42 27 2 0.127 1.000 1.000 530 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CSNK1D(1), EGF(3), EGFR(13), GJA1(4), GNA11(1), GNAI1(1), GNAS(3), GRM1(4), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), HTR2A(1), HTR2B(2), HTR2C(1), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(3), NPR1(1), NPR2(2), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), SOS1(1), SOS2(4), TJP1(4), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB3(3), TUBB6(2), TUBB8(1) 43207722 139 59 136 45 43 23 16 29 26 2 0.159 1.000 1.000 531 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADK(1), ADSL(3), ADSSL1(1), AK5(1), AK7(4), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), CANT1(3), ENPP1(1), ENPP3(2), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), GART(3), GMPR(1), GMPR2(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5E(1), NT5M(1), PAICS(1), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE7A(1), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(5), POLR3GL(1), PPAT(2), PRIM1(1), PRIM2(2), PRPS1L1(1), PRPS2(3), RRM1(3), XDH(7) 53337016 157 56 155 49 51 30 15 41 20 0 0.0553 1.000 1.000 532 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(4), CD22(1), CD226(1), CD274(1), CD276(1), CD28(1), CD4(1), CD40(1), CD40LG(2), CDH1(3), CDH15(1), CDH2(2), CDH3(1), CDH4(3), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(1), CNTNAP1(4), CNTNAP2(4), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-A(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(3), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ITGA4(2), ITGA6(3), ITGA8(3), ITGAL(1), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(3), JAM3(2), L1CAM(4), MPZ(1), NCAM1(1), NEGR1(2), NEO1(5), NLGN1(2), NLGN2(2), NLGN3(2), NRCAM(3), NRXN1(5), NRXN3(2), OCLN(1), PDCD1LG2(1), PTPRC(4), PTPRF(3), PTPRM(4), PVR(2), PVRL1(1), SDC1(1), SDC3(1), SELE(4), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(1), VCAN(5) 48273981 154 55 153 55 43 37 13 39 22 0 0.157 1.000 1.000 533 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), CCL5(1), CD40(1), CXCL9(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IKBKE(4), IL12B(2), IL1B(1), IL6(1), IRAK4(1), IRF7(2), LBP(1), MAP2K2(1), MAP2K3(2), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CA(21), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(14), PIK3R2(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(1), SPP1(1), STAT1(2), TBK1(2), TICAM1(1), TLR1(1), TLR3(5), TLR6(2), TLR7(3), TLR9(1), TRAF3(1) 29315149 105 53 95 34 21 19 20 19 24 2 0.254 1.000 1.000 534 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(3), ACVR1B(2), ACVRL1(3), AKT1(1), BUB1(3), CDS2(2), CLK1(2), CLK4(1), CSNK2A1(2), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(3), INPPL1(4), NEK3(1), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CA(21), PIK3CB(1), PIK3CG(4), PIM2(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(7), PLK3(1), PRKACG(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(1), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), TGFBR1(1), VRK1(3) 36829753 117 52 108 38 28 21 18 26 21 3 0.284 1.000 1.000 535 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(2), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ARRB1(2), ATF4(1), ATF5(1), ATP2A2(3), ATP2A3(1), CACNB3(1), CALCA(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), GABPA(2), GABPB2(1), GBA2(1), GJA1(4), GNB5(1), GNG12(1), GRK4(4), GRK5(4), GUCY1A3(1), IGFBP2(1), IGFBP3(1), IL1B(1), IL6(1), ITPR1(2), ITPR2(11), ITPR3(6), MIB1(1), MYL2(1), MYLK2(1), NFKB1(1), NOS1(2), NOS3(5), PDE4D(3), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(7), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCQ(1), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(1), RLN1(1), RYR1(9), RYR2(11), RYR3(8), TNXB(9), YWHAH(1), YWHAQ(1) 56502908 169 52 167 64 59 24 20 42 22 2 0.388 1.000 1.000 536 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA3(2), ADRA1A(1), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCBP2(1), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CHML(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD3(1), DRD5(2), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GPR174(1), GPR35(1), GPR37(1), GPR4(1), GPR50(2), GPR6(1), GPR63(1), GPR77(1), GPR83(2), GPR85(2), GPR87(1), GRPR(2), HCRTR2(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LTB4R(1), MC3R(1), MC4R(3), MC5R(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPY1R(3), NTSR1(1), OPN1SW(1), OPN3(1), OPRL1(1), OPRM1(1), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(2), OR7C1(1), P2RY1(1), P2RY12(1), P2RY13(1), P2RY2(3), P2RY6(2), PPYR1(2), PTGER4(1), PTGFR(5), SSTR2(1), SSTR3(2), SSTR4(5), SUCNR1(1), TBXA2R(1), TRHR(2) 39696183 146 51 146 53 47 23 17 44 15 0 0.153 1.000 1.000 537 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(3), CACNA1A(1), GNA11(1), GNAI1(1), GNAO1(2), GNAS(3), GRIA1(4), GRIA2(2), GRIA3(5), GRID2(3), GRM1(4), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IGF1R(3), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(2), NOS3(5), NPR1(1), NPR2(2), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PPP2CB(1), PPP2R2C(3), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), RYR1(9) 36016225 115 46 115 34 28 18 19 25 23 2 0.115 1.000 1.000 538 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(2), ACTN2(6), ACTN3(1), ACTN4(2), DMD(6), FAM48A(1), MYBPC1(2), MYBPC2(3), MYH3(6), MYH6(2), MYH7(5), MYH8(7), MYL1(1), MYL2(1), MYOM1(1), NEB(16), TNNI1(1), TNNT1(1), TNNT3(1), TPM1(4), TPM2(1), TPM3(2), TPM4(1), TTN(66), VIM(2) 44367286 141 46 141 40 42 26 18 41 12 2 0.0547 1.000 1.000 539 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2B(2), ASCC3(2), ATP13A2(1), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), ENPP1(1), ENPP3(2), EP400(2), ERCC2(1), ERCC3(1), G6PC(3), G6PC2(1), GAA(5), GANC(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), IFIH1(1), LYZL1(1), MGAM(4), MOV10L1(1), PYGB(1), PYGL(3), PYGM(1), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(3), SI(6), SKIV2L2(2), SMARCA2(1), SMARCA5(1), TREH(1), UGDH(1), UGP2(1), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UXS1(2) 40423287 115 45 114 36 32 20 19 33 11 0 0.199 1.000 1.000 540 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(8), CTBP1(3), DTX1(1), DTX2(1), DTX3L(1), DTX4(1), DVL2(1), DVL3(1), EP300(3), HDAC2(5), JAG1(2), LFNG(1), MAML1(1), MAML2(1), MAML3(3), MFNG(1), NCOR2(3), NCSTN(3), NOTCH1(26), NOTCH2(10), NOTCH3(4), NOTCH4(8), NUMBL(2), RBPJ(2), RBPJL(1), SNW1(2) 22598968 95 45 92 32 24 13 6 20 28 4 0.512 1.000 1.000 541 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(4), ASH2L(1), CTCFL(2), DOT1L(2), EHMT1(4), EHMT2(2), EZH1(3), EZH2(1), HCFC1(2), HSF4(1), JMJD6(2), KDM6A(2), MEN1(1), MLL(7), MLL2(19), MLL3(12), MLL5(2), NSD1(2), OGT(6), PAXIP1(1), PPP1CB(1), PRDM2(3), PRDM7(2), PRDM9(6), PRMT5(1), PRMT6(1), SATB1(2), SETD1A(1), SETD2(6), SETD7(3), SETD8(1), SETDB1(1), SETDB2(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(2), WHSC1L1(3) 38709017 114 42 114 30 31 19 15 33 16 0 0.0775 1.000 1.000 542 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), AKAP11(1), AKAP12(1), AKAP3(1), AKAP4(4), AKAP5(2), AKAP6(8), AKAP7(1), AKAP8(2), AKAP9(5), ARHGEF1(1), GNA11(1), GNA14(1), GNAL(1), GNAO1(2), GNB5(1), GNG12(1), ITPR1(2), KCNJ3(1), KRAS(1), NRAS(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE7A(1), PDE7B(2), PDE8A(4), PLCB3(3), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), RRAS(1) 38245125 91 38 91 45 28 14 8 21 18 2 0.889 1.000 1.000 543 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(3), B3GNT7(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHST3(2), CHST4(1), CHSY1(1), DAD1(1), DPAGT1(1), EXT1(3), EXT2(2), EXTL1(2), EXTL3(1), FUT8(3), GALNT1(1), GALNT12(2), GALNT14(2), GALNT2(2), GALNT4(2), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GANAB(2), GCNT4(2), HS6ST2(3), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(2), NDST1(2), NDST2(2), NDST3(2), NDST4(1), OGT(6), RPN2(1), ST3GAL1(1), ST3GAL4(1), ST6GAL1(1), ST6GALNAC1(1), STT3B(1), WBSCR17(4), XYLT1(1), XYLT2(1) 35958403 103 38 103 33 31 19 12 27 14 0 0.271 1.000 1.000 544 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3L1(1), CREB3L2(1), CREBBP(8), DVL2(1), DVL3(1), EDNRB(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAO1(2), GNAS(3), KIT(3), KITLG(2), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PRKACG(1), PRKCA(3), PRKCG(1), RAF1(1), TCF7L2(2), TYR(4), TYRP1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1) 35559005 95 38 95 33 35 9 7 26 16 2 0.272 1.000 1.000 545 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADK(1), ADSL(3), AK5(1), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), ATP5B(1), ATP5G2(1), CANT1(3), ENPP1(1), ENPP3(2), ENTPD1(1), GART(3), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5E(1), NT5M(1), PAICS(1), PDE1A(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE6B(3), PDE6C(6), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), PPAT(2), PRPS1L1(1), PRPS2(3), RRM1(3) 41879607 118 38 118 48 43 25 11 27 12 0 0.499 1.000 1.000 546 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(3), CREB1(1), DAXX(2), ELK1(3), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K8(2), MAP3K9(3), MAP4K3(1), MAP4K4(2), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), NFKB1(1), NFKBIA(1), PAK1(2), RAC1(1), RAF1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1) 31017992 86 32 85 33 24 10 14 21 15 2 0.598 1.000 1.000 547 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(3), ACSL3(2), ACSL4(1), ACSL6(1), ADIPOR1(2), ADIPOR2(3), AKT1(1), CAMKK1(1), CAMKK2(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), G6PC(3), G6PC2(1), IRS1(2), IRS2(1), IRS4(6), JAK2(3), JAK3(1), LEPR(1), MAPK10(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(3), PPARA(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(1), PTPN11(6), RELA(1), RXRA(1), RXRG(3), SLC2A1(1), SLC2A4(1), STAT3(1), TNFRSF1B(2), TRADD(1), TYK2(5) 27113275 87 29 85 36 23 18 4 28 13 1 0.663 1.000 1.000 548 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(3), ABCA12(3), ABCA13(10), ABCA2(3), ABCA3(3), ABCA4(3), ABCA5(2), ABCA6(5), ABCA7(4), ABCA8(3), ABCA9(2), ABCB1(3), ABCB11(1), ABCB4(4), ABCB5(3), ABCB7(2), ABCB8(1), ABCB9(1), ABCC1(4), ABCC10(7), ABCC11(3), ABCC12(4), ABCC3(5), ABCC4(2), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(3), ABCD1(2), ABCG1(1), ABCG4(2), ABCG5(3), ABCG8(3), CFTR(2) 38522644 105 28 105 41 28 18 15 30 12 2 0.507 1.000 1.000 549 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GNRHR(2), GPR77(1), GRPR(2), MC3R(1), MC4R(3), MC5R(1), NMBR(3), NPY1R(3), NTSR1(1), OPRL1(1), OPRM1(1), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(5), TACR2(1), TRHR(2), TSHR(4) 17108011 60 26 60 27 19 10 10 18 3 0 0.569 1.000 1.000 550 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACAT2(1), ACOX1(1), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2) 16018658 52 22 52 21 14 8 3 14 13 0 0.652 1.000 1.000 551 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), AOX1(3), CAT(2), CYP1A2(2), CYP1B1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2), KMO(2), LCMT1(2), LCMT2(1), LNX1(3), METTL2B(3), METTL6(1), NFX1(1), OGDHL(2), PRMT2(2), PRMT5(1), PRMT6(1), TDO2(1), TPH1(2), TPH2(1), WARS2(2) 19815859 59 22 59 25 22 10 4 13 10 0 0.613 1.000 1.000 552 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), AOX1(3), CAT(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), KMO(2), TDO2(1), TPH1(2), WARS2(2) 17991212 48 22 48 21 18 9 3 9 9 0 0.705 1.000 1.000 553 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH4A1(2), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), GOT1(2), NOS1(2), NOS3(5), OAT(1), ODC1(2), P4HA1(1), RARS(2), SMS(1) 14460858 46 20 46 22 17 10 3 7 9 0 0.771 1.000 1.000 554 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(1), FTCD(1), HAL(1), HARS(1), HARS2(1), HDC(2), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRPS2(3) 12966290 42 18 42 18 19 8 3 9 3 0 0.499 1.000 1.000 555 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPNS1(1), CAPNS2(1), EGF(3), EGFR(13), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PRKACG(1), PRKAR1A(1), PTK2(1), TLN1(2) 10679600 33 18 30 14 7 4 4 12 5 1 0.783 1.000 1.000 556 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(6), FAU(1), IL6ST(2), MRPL19(2), RPL10(3), RPL13A(1), RPL15(1), RPL18A(1), RPL29(1), RPL32(1), RPL36(1), RPL5(1), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(1), RPS3(1), RPS4X(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), RPSA(2), SLC36A2(1), TBC1D10C(1), UBC(7) 17094562 51 18 49 17 13 8 5 18 7 0 0.603 1.000 1.000 557 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), ARHGEF11(1), DLG4(3), LPA(5), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PDK1(2), PHKA2(4), PI3(1), PIK3CB(1), PLD1(5), PLD3(1), PTK2(1), RDX(5), ROCK1(2), ROCK2(2), SERPINA4(1), SRF(2), TBXA2R(1) 16007579 47 17 47 17 14 8 6 12 6 1 0.519 1.000 1.000 558 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(2), AGXT(2), AGXT2(1), ALAS1(1), ATP6V0C(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PLCB2(1), PLCG1(6), PLCG2(7), SARDH(2), SHMT1(1) 13758495 34 16 33 17 13 10 2 4 5 0 0.682 1.000 1.000 559 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(2), ADC(2), ALDH18A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), ARG2(1), ASL(2), ASS1(1), CPS1(4), ODC1(2), SMS(1), SRM(1) 9640696 31 16 31 12 11 4 3 4 9 0 0.585 1.000 1.000 560 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), HSD17B4(2), NSD1(2), OGDHL(2), PIPOX(1), PLOD1(2), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(3), SETDB1(1), SHMT1(1), SUV39H1(1), TMLHE(1) 18990407 49 16 49 22 21 6 2 8 12 0 0.676 1.000 1.000 561 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), EPRS(2), GLUD1(3), GLUD2(1), GOT1(2), LAP3(1), NOS1(2), NOS3(5), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4) 11747414 38 16 38 16 11 9 2 9 7 0 0.687 1.000 1.000 562 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(2), ALDH1A3(3), ALDH3A1(5), DDC(1), EPX(2), ESCO2(2), GOT1(2), HPD(1), LPO(5), MPO(2), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(3) 11182153 33 16 33 14 15 8 3 4 3 0 0.506 1.000 1.000 563 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), AKT1(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PDK1(2), PHKA2(4), PIK3CB(1), PITX2(3), PLD1(5), PLD3(1) 14644016 43 16 43 18 14 7 8 10 3 1 0.576 1.000 1.000 564 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CCND1(1), CREBBP(8), EP300(3), ERCC3(1), ESR1(1), GRIP1(1), GTF2E1(3), GTF2F1(2), HDAC2(5), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), NCOR2(3), NRIP1(1), PELP1(1), POLR2A(3) 15076153 41 15 41 22 11 5 2 13 10 0 0.962 1.000 1.000 565 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1G(1), ELK1(3), FPR1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NCF1(1), NCF2(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(1), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1) 12501259 38 15 38 18 15 4 1 8 9 1 0.753 1.000 1.000 566 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ASPA(1), CNDP1(2), DDC(1), HAL(1), HARS(1), HDC(2), PRPS2(3) 7996227 26 15 26 13 14 5 2 3 2 0 0.676 1.000 1.000 567 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(1), FUCA2(1), GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NAGLU(2), NEU1(1), NEU2(2), NEU3(1), SPAM1(1) 11256997 30 15 30 16 8 3 5 8 6 0 0.931 1.000 1.000 568 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(2), ALDH1A3(3), ALDH3A1(5), DDC(1), EPX(2), GOT1(2), HPD(1), LPO(5), MPO(2), PRDX1(1), TAT(1), TPO(3) 7190390 28 15 28 13 14 6 3 2 3 0 0.506 1.000 1.000 569 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(2), AXIN1(1), CCND1(1), CSNK1E(1), DVL2(1), DVL3(1), FZD1(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), MAPK10(1), MAPK9(1), PAFAH1B1(4), PLAU(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), RAC1(1), SFRP4(1), WNT11(4), WNT2(2), WNT2B(1), WNT5B(1), WNT7A(1) 19610292 40 15 40 18 14 3 7 9 5 2 0.659 1.000 1.000 570 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(2), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), MLYCD(3), SMS(1) 9502426 34 14 34 14 13 7 2 7 5 0 0.518 1.000 1.000 571 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPP(2), ASCC3(2), ATP13A2(1), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), EP400(2), ERCC2(1), ERCC3(1), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(3), SKIV2L2(2), SMARCA2(1), SMARCA5(1), SPR(1) 20484502 42 14 42 18 14 9 4 9 6 0 0.745 1.000 1.000 572 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), ANKRD6(2), APC(2), AXIN1(1), CSNK1A1(2), DACT1(2), DKK1(1), DKK2(2), DKK4(2), LRP1(15), NKD2(1), PTPRA(4), SENP2(2), SFRP1(1), WIF1(2) 13170762 40 14 40 15 12 8 3 13 4 0 0.616 1.000 1.000 573 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(4), CUL1(1), CUL2(3), CUL3(1), FBXW7(1), FZR1(2), SKP2(2), SMURF1(1), SMURF2(1), UBE2D3(2), UBE2D4(2), WWP1(3) 13127225 35 13 33 18 6 5 5 11 8 0 0.967 1.000 1.000 574 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB1(1), EEF2K(1), EIF4E(1), ELK1(3), IL1R1(1), MAP2K3(2), MAP3K4(4), MAP3K5(2), MAPK1(1), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MYEF2(2), NFKB1(1), NR2C2(1), SRF(2) 10870869 29 13 29 14 8 3 7 7 4 0 0.820 1.000 1.000 575 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(3), APOA1(1), APOA4(2), APOE(1), CETP(1), CYP7A1(1), LIPC(1), LPL(2), LRP1(15), SCARB1(1), SOAT1(1) 8950619 29 13 29 12 10 6 1 9 3 0 0.663 1.000 1.000 576 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C5(4), C6(2), C7(4), C8A(1), MBL2(2) 6947273 29 12 29 11 8 3 4 8 6 0 0.568 1.000 1.000 577 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCR(1), ELTD1(1), EMR1(2), EMR2(2), GHRHR(2), GIPR(2), GLP2R(1), GPR64(2), LPHN1(1), LPHN2(5), LPHN3(3), VIPR1(1) 8723239 26 12 26 12 5 5 6 10 0 0 0.807 1.000 1.000 578 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(1), ANXA6(2), EDNRB(1), HSD11B1(1), PLA2G4A(4), PTGER4(1), PTGFR(5), PTGS1(2), PTGS2(2), SCGB1A1(1) 6744468 24 12 24 10 7 3 3 8 3 0 0.732 1.000 1.000 579 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(1), CASP1(1), CASP10(1), CASP4(1), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(1), FAS(1), IKBKE(4), NFKB1(1), NFKBIA(1), NGFR(1), NR3C1(2), PTPN13(1), RIPK1(1), TFG(1), TNFRSF1B(2), TRADD(1), TRAF3(1) 14177378 31 11 31 16 11 5 1 6 8 0 0.839 1.000 1.000 580 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1) 6653788 18 11 18 13 5 2 2 5 4 0 0.983 1.000 1.000 581 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(2), AXIN1(1), CREBBP(8), EP300(3), FZD1(1), LDB1(2), PITX2(3), TRRAP(7) 10839859 27 11 27 12 9 4 1 11 2 0 0.737 1.000 1.000 582 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 ELK1(3), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), NFKBIA(1), PPARA(2), RELA(1), TLR10(4), TLR3(5), TLR6(2), TLR7(3), TLR9(1) 11930811 29 11 28 15 8 6 5 7 3 0 0.838 1.000 1.000 583 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C5(4), C6(2), C7(4), C8A(1) 5709916 27 10 27 10 8 3 3 8 5 0 0.535 1.000 1.000 584 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C5(4), C6(2), C7(4), C8A(1), C8B(2) 6788833 29 10 29 14 8 5 3 8 5 0 0.755 1.000 1.000 585 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDK2(1), CDT1(1), DIAPH2(1), GMNN(1), MCM10(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), POLD1(1), POLD2(2), POLD3(2), POLE(7), PRIM1(1), RFC4(2), RPA1(2), UBC(7) 16543469 41 10 39 18 7 4 5 17 8 0 0.837 1.000 1.000 586 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5D(1), GRM1(4), GRM2(3), GRM3(4), GRM4(2), GRM5(2), GRM7(2), GRM8(1) 6869392 23 10 23 12 7 4 1 7 4 0 0.878 1.000 1.000 587 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLB(1), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLG(1), POLH(1), POLI(4), POLK(1), POLL(1), POLM(2), POLQ(1), PRIM1(1), PRIM2(2), REV1(2), REV3L(3) 13197584 34 10 34 13 6 5 3 12 8 0 0.827 1.000 1.000 588 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(1), GTF2E1(3), GTF2H1(1), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3B(5), POLR3D(1), TAF6(1), TAF9(2) 11458992 28 10 27 23 9 5 1 9 4 0 0.995 1.000 1.000 589 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(3), E2F1(1), ETS1(3), ETV3(1), HDAC2(5), HDAC5(1), NCOR2(3), RBL1(2), RBL2(2), SIN3A(1), SIN3B(1) 8483748 23 9 23 10 5 4 1 6 7 0 0.803 1.000 1.000 590 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(5), POLR3GL(1) 7677525 23 9 22 11 7 3 2 8 3 0 0.748 1.000 1.000 591 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IL1B(1), IL1R1(1), IL1RAP(1), IL6(1), IRAK2(1), IRAK3(4), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), NFKBIA(1), RELA(1), TGFB2(2), TGFB3(1) 9681245 22 9 22 10 6 4 4 5 3 0 0.720 1.000 1.000 592 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), PFKL(2), PLCG1(6), RAC1(1), RPS6KB1(1), VAV2(1) 8128976 19 9 18 10 6 6 1 3 3 0 0.771 1.000 1.000 593 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(3), MARS(4), MARS2(1), MTFMT(1), MTR(2), SRM(1), TAT(1) 6785366 25 8 25 11 6 5 1 10 1 2 0.650 1.000 1.000 594 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR4(1), CCR7(1), CD28(1), CD4(1), CXCR4(1), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1), TGFB2(2), TGFB3(1) 6531957 13 8 13 10 4 2 3 3 1 0 0.946 1.000 1.000 595 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(8), EP300(3), IL1B(1), MAP2K3(2), MAP3K14(1), NFKB1(1), NFKBIA(1), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(2) 9703149 23 8 23 12 5 3 2 9 4 0 0.898 1.000 1.000 596 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2E1(3), GTF2F1(2), HDAC3(1), NCOA1(1), NCOA3(1), NCOR2(3), POLR2A(3), RXRA(1) 8149316 16 8 16 14 3 4 0 6 3 0 0.987 1.000 1.000 597 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(2), AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PHGDH(2), PIPOX(1), SARDH(2), SARS2(2), SHMT1(1), TARS2(1) 13965240 27 7 27 15 6 9 3 3 6 0 0.785 1.000 1.000 598 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), LPO(5), MPO(2), TPO(3) 2732106 12 7 12 5 6 5 0 1 0 0 0.401 1.000 1.000 599 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IL1R1(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1) 7952070 12 7 12 12 6 0 1 1 4 0 0.993 1.000 1.000 600 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(8), EP300(3), HDAC3(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNFRSF1B(2), TRADD(1) 7305473 19 7 19 11 6 1 0 7 5 0 0.939 1.000 1.000 601 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(3), CREB1(1), DUSP4(1), DUSP9(2), EEF2K(1), EIF4E(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), NFKB1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(1), SOS2(4), TRAF3(1) 9642812 28 7 28 12 8 2 5 9 3 1 0.664 1.000 1.000 602 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(1), ACOX3(3), FADS2(2), FASN(1), SCD(1) 4680768 8 5 8 11 1 1 0 4 2 0 0.998 1.000 1.000 603 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), FTCD(1), GART(3), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1) 6190459 19 4 19 10 5 6 2 4 1 1 0.747 1.000 1.000 604 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(2), CES1(1) 1976473 3 3 3 3 1 1 1 0 0 0 0.904 1.000 1.000 605 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2) 3771087 4 3 4 4 1 1 1 1 0 0 0.954 1.000 1.000 606 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT2(2) 1995071 3 2 3 3 1 0 1 1 0 0 0.969 1.000 1.000 607 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR2(2), IFNB1(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF11A(2) 3621228 8 2 8 7 1 1 1 5 0 0 0.970 1.000 1.000 608 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2) 2059797 2 2 2 3 1 0 1 0 0 0 0.979 1.000 1.000 609 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(3), FYN(1), THBS1(1) 2417804 5 2 5 4 2 2 1 0 0 0 0.840 1.000 1.000 610 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1) 3026565 6 1 6 5 1 0 3 2 0 0 0.951 1.000 1.000 611 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1) 1988165 1 1 1 2 0 0 1 0 0 0 0.971 1.000 1.000 612 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), SULT2A1(1), SUOX(1) 2000721 3 1 3 3 0 1 0 2 0 0 0.959 1.000 1.000 613 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 236839 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 166633 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 499787 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 560372 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000