E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.044 0.178 -9999.0 0.0 -0.486 34.0 34.0 KLHL20 -0.027 0.056 -9999.0 0.0 -0.277 3.0 3.0 CYFIP2 0.008 0.059 -9999.0 0.0 -0.542 3.0 3.0 Rac1/GDP 0.004 0.12 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.045 0.178 -9999.0 0.0 -0.486 34.0 34.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.031 -9999.0 0.0 -0.49 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.04 0.075 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.018 0.039 -9999.0 0.0 -0.177 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.1 0.174 -9999.0 0.0 -0.435 42.0 42.0 RAPGEF1 -0.019 0.157 -9999.0 0.0 -0.409 34.0 34.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.082 0.168 -9999.0 0.0 -0.507 34.0 34.0 CRK -0.031 0.169 -9999.0 0.0 -0.45 34.0 34.0 E-cadherin/gamma catenin/alpha catenin -0.089 0.156 -9999.0 0.0 -0.344 70.0 70.0 alphaE/beta7 Integrin -0.033 0.115 -9999.0 0.0 -0.423 21.0 21.0 IQGAP1 0.009 0.053 -9999.0 0.0 -0.49 3.0 3.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.002 0.027 -9999.0 0.0 -0.364 1.0 1.0 DLG1 -0.043 0.178 -9999.0 0.0 -0.486 34.0 34.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.054 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.012 0.04 -9999.0 0.0 -0.646 1.0 1.0 ARF6/GTP/NME1/Tiam1 -0.001 0.022 -9999.0 0.0 -0.364 1.0 1.0 PI3K -0.036 0.068 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.107 0.186 -9999.0 0.0 -0.413 70.0 70.0 TIAM1 0.012 0.04 -9999.0 0.0 -0.646 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.071 0.125 -9999.0 0.0 -0.336 34.0 34.0 AKT1 -0.021 0.039 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.132 0.255 -9999.0 0.0 -0.568 68.0 68.0 RhoA/GDP 0.004 0.12 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.02 0.042 -9999.0 0.0 -0.199 3.0 3.0 CDC42/GDP 0.004 0.12 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.034 0.113 -9999.0 0.0 -0.289 35.0 35.0 ITGB7 -0.032 0.162 -9999.0 0.0 -0.587 21.0 21.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.075 0.133 -9999.0 0.0 -0.356 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.073 0.129 -9999.0 0.0 -0.29 68.0 68.0 mol:GDP -0.007 0.136 -9999.0 0.0 -0.331 34.0 34.0 CDC42/GTP/IQGAP1 -0.003 0.03 -9999.0 0.0 -0.288 3.0 3.0 JUP 0.007 0.064 -9999.0 0.0 -0.594 3.0 3.0 p120 catenin/RhoA/GDP -0.047 0.095 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.003 0.03 -9999.0 0.0 -0.288 3.0 3.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.062 -9999.0 0.0 -0.216 13.0 13.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.044 0.178 -9999.0 0.0 -0.486 34.0 34.0 regulation of cell-cell adhesion -0.036 0.066 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.009 0.02 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.046 0.086 -9999.0 0.0 -0.322 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.095 0.168 -9999.0 0.0 -0.42 42.0 42.0 CCND1 0.011 0.076 -9999.0 0.0 -0.27 13.0 13.0 VAV2 -0.025 0.165 -9999.0 0.0 -0.437 34.0 34.0 RAP1/GDP -0.045 0.09 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.04 0.173 -9999.0 0.0 -0.47 34.0 34.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.089 0.158 -9999.0 0.0 -0.599 13.0 13.0 E-cadherin/beta catenin -0.075 0.143 -9999.0 0.0 -0.414 34.0 34.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.043 0.178 -9999.0 0.0 -0.486 34.0 34.0 PIK3CA 0.012 0.04 -9999.0 0.0 -0.646 1.0 1.0 Rac1/GTP -0.044 0.09 -9999.0 0.0 -0.476 3.0 3.0 E-cadherin/beta catenin/alpha catenin -0.085 0.15 -9999.0 0.0 -0.339 68.0 68.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.084 0.172 -9999.0 0.0 -0.52 34.0 34.0