Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.087 0.298 -9999.0 0.0 -0.752 31.0 31.0 IHH -0.008 0.075 -9999.0 0.0 -0.488 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.09 0.16 -9999.0 0.0 -0.405 42.0 42.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.09 0.159 0.402 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.027 0.175 -9999.0 0.0 -0.655 10.0 10.0 SMO -0.037 0.185 -9999.0 0.0 -0.628 13.0 13.0 AKT1 0.007 0.09 -9999.0 0.0 -0.387 4.0 4.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.006 0.071 -9999.0 0.0 -0.568 4.0 4.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.036 0.182 -9999.0 0.0 -0.615 13.0 13.0 STIL -0.081 0.224 -9999.0 0.0 -0.585 29.0 29.0 DHH N/PTCH2 -0.055 0.143 -9999.0 0.0 -0.415 36.0 36.0 DHH N/PTCH1 -0.058 0.201 -9999.0 0.0 -0.578 21.0 21.0 PIK3CA 0.012 0.04 -9999.0 0.0 -0.646 1.0 1.0 DHH -0.042 0.171 -9999.0 0.0 -0.562 26.0 26.0 PTHLH -0.1 0.349 -9999.0 0.0 -0.972 30.0 30.0 determination of left/right symmetry -0.036 0.182 -9999.0 0.0 -0.615 13.0 13.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.098 0.343 -9999.0 0.0 -0.954 30.0 30.0 IHH N/Hhip -0.135 0.229 -9999.0 0.0 -0.47 83.0 83.0 DHH N/Hhip -0.164 0.22 -9999.0 0.0 -0.436 102.0 102.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.036 0.182 -9999.0 0.0 -0.615 13.0 13.0 pancreas development -0.166 0.276 -9999.0 0.0 -0.58 82.0 82.0 HHAT -0.004 0.103 -9999.0 0.0 -0.587 8.0 8.0 PI3K -0.002 0.029 -9999.0 0.0 -0.474 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.022 0.134 -9999.0 0.0 -0.507 19.0 19.0 somite specification -0.036 0.182 -9999.0 0.0 -0.615 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.084 0.225 -9999.0 0.0 -0.565 32.0 32.0 SHH Np/Cholesterol/PTCH2 -0.084 0.159 -9999.0 0.0 -0.396 42.0 42.0 SHH Np/Cholesterol/Megalin -0.18 0.218 -9999.0 0.0 -0.462 78.0 78.0 SHH -0.075 0.195 -9999.0 0.0 -0.435 59.0 59.0 catabolic process -0.037 0.185 -9999.0 0.0 -0.625 13.0 13.0 SMO/Vitamin D3 -0.075 0.225 -9999.0 0.0 -0.607 25.0 25.0 SHH Np/Cholesterol/Hhip -0.167 0.221 -9999.0 0.0 -0.462 75.0 75.0 LRP2 -0.19 0.284 -9999.0 0.0 -0.575 94.0 94.0 receptor-mediated endocytosis -0.171 0.224 -9999.0 0.0 -0.6 43.0 43.0 SHH Np/Cholesterol/BOC -0.076 0.148 -9999.0 0.0 -0.387 38.0 38.0 SHH Np/Cholesterol/CDO -0.088 0.158 -9999.0 0.0 -0.392 45.0 45.0 mesenchymal cell differentiation 0.167 0.218 0.459 75.0 -9999.0 0.0 75.0 mol:Vitamin D3 -0.082 0.226 -9999.0 0.0 -0.565 32.0 32.0 IHH N/PTCH2 -0.007 0.109 -9999.0 0.0 -0.502 11.0 11.0 CDON -0.016 0.134 -9999.0 0.0 -0.61 13.0 13.0 IHH N/PTCH1 -0.038 0.187 -9999.0 0.0 -0.63 13.0 13.0 Megalin/LRPAP1 -0.143 0.201 -9999.0 0.0 -0.413 94.0 94.0 PTCH2 -0.009 0.119 -9999.0 0.0 -0.615 10.0 10.0 SHH Np/Cholesterol -0.074 0.146 -9999.0 0.0 -0.34 59.0 59.0 PTCH1 -0.038 0.186 -9999.0 0.0 -0.628 13.0 13.0 HHIP -0.166 0.277 -9999.0 0.0 -0.581 82.0 82.0