Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.032 0.116 -9999.0 0.0 -0.275 41.0 41.0 epithelial cell differentiation -0.07 0.124 -9999.0 0.0 -0.333 34.0 34.0 CYFIP2 0.008 0.059 -9999.0 0.0 -0.542 3.0 3.0 ENAH 0.006 0.106 -9999.0 0.0 -0.358 2.0 2.0 EGFR -0.078 0.216 -9999.0 0.0 -0.57 43.0 43.0 EPHA2 -0.016 0.122 -9999.0 0.0 -0.5 16.0 16.0 MYO6 -0.033 0.134 -9999.0 0.0 -0.311 34.0 34.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.004 0.034 -9999.0 0.0 -0.399 1.0 1.0 AQP5 -0.14 0.188 -9999.0 0.0 -0.544 35.0 35.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.033 0.132 -9999.0 0.0 -0.307 34.0 34.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.139 -9999.0 0.0 -0.316 38.0 38.0 EGF -0.039 0.172 -9999.0 0.0 -0.587 24.0 24.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.089 0.154 -9999.0 0.0 -0.577 15.0 15.0 cortical microtubule organization -0.07 0.124 -9999.0 0.0 -0.333 34.0 34.0 GO:0000145 -0.031 0.126 -9999.0 0.0 -0.293 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.071 0.125 -9999.0 0.0 -0.336 34.0 34.0 MLLT4 0.012 0.04 -9999.0 0.0 -0.646 1.0 1.0 ARF6/GDP -0.061 0.097 -9999.0 0.0 -0.412 2.0 2.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.016 0.061 -9999.0 0.0 -0.356 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.035 0.133 -9999.0 0.0 -0.449 2.0 2.0 PVRL2 0.012 0.04 -9999.0 0.0 -0.646 1.0 1.0 ZYX -0.038 0.135 -9999.0 0.0 -0.311 34.0 34.0 ARF6/GTP -0.014 0.055 -9999.0 0.0 -0.323 1.0 1.0 CDH1 -0.132 0.255 -9999.0 0.0 -0.568 68.0 68.0 EGFR/EGFR/EGF/EGF -0.127 0.176 -9999.0 0.0 -0.563 21.0 21.0 RhoA/GDP -0.065 0.114 -9999.0 0.0 -0.308 34.0 34.0 actin cytoskeleton organization -0.026 0.129 -9999.0 0.0 -0.294 34.0 34.0 IGF-1R heterotetramer 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.012 0.121 -9999.0 0.0 -0.568 12.0 12.0 DIAPH1 0.001 0.047 -9999.0 0.0 -0.698 1.0 1.0 Wnt receptor signaling pathway 0.07 0.124 0.333 34.0 -9999.0 0.0 34.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.061 0.098 -9999.0 0.0 -0.413 2.0 2.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.027 0.132 -9999.0 0.0 -0.301 34.0 34.0 EFNA1 0.012 0.031 -9999.0 0.0 -0.49 1.0 1.0 LPP -0.049 0.146 -9999.0 0.0 -0.52 3.0 3.0 Ephrin A1/EPHA2 -0.074 0.117 -9999.0 0.0 -0.479 2.0 2.0 SEC6/SEC8 -0.057 0.104 -9999.0 0.0 -0.528 2.0 2.0 MGAT3 -0.04 0.141 -9999.0 0.0 -0.321 38.0 38.0 HGF/MET -0.172 0.181 -9999.0 0.0 -0.519 35.0 35.0 HGF -0.08 0.205 -9999.0 0.0 -0.519 48.0 48.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.032 0.117 -9999.0 0.0 -0.277 41.0 41.0 actin cable formation 0.017 0.108 -9999.0 0.0 -0.341 2.0 2.0 KIAA1543 -0.069 0.184 -9999.0 0.0 -0.617 12.0 12.0 KIFC3 -0.036 0.138 -9999.0 0.0 -0.321 34.0 34.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.05 0.143 -9999.0 0.0 -0.322 36.0 36.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.07 0.124 -9999.0 0.0 -0.333 34.0 34.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.033 0.134 -9999.0 0.0 -0.311 34.0 34.0 PIP5K1C -0.033 0.134 -9999.0 0.0 -0.311 34.0 34.0 LIMA1 -0.003 0.105 -9999.0 0.0 -0.646 7.0 7.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.053 0.085 -9999.0 0.0 -0.393 1.0 1.0 adherens junction assembly -0.048 0.18 -9999.0 0.0 -0.577 12.0 12.0 IGF-1R heterotetramer/IGF1 -0.073 0.127 -9999.0 0.0 -0.6 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.003 0.041 -9999.0 0.0 -0.474 2.0 2.0 MET -0.148 0.261 -9999.0 0.0 -0.557 77.0 77.0 PLEKHA7 -0.041 0.142 -9999.0 0.0 -0.328 35.0 35.0 mol:GTP -0.016 0.061 -9999.0 0.0 -0.354 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.001 0.126 -9999.0 0.0 -0.499 2.0 2.0 cortical actin cytoskeleton stabilization -0.032 0.116 -9999.0 0.0 -0.275 41.0 41.0 regulation of cell-cell adhesion -0.026 0.129 -9999.0 0.0 -0.294 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.032 0.117 -9999.0 0.0 -0.277 41.0 41.0