E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.029 0.146 -9999.0 0.0 -0.419 32.0 32.0 KLHL20 0.009 0.072 0.16 2.0 -0.206 2.0 4.0 CYFIP2 0.023 0.032 -9999.0 0.0 -0.449 1.0 1.0 Rac1/GDP -0.006 0.102 0.259 3.0 -0.263 29.0 32.0 ENAH -0.037 0.155 -9999.0 0.0 -0.425 36.0 36.0 AP1M1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.005 0.07 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.036 -9999.0 0.0 -0.147 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.013 0.13 -9999.0 0.0 -0.286 40.0 40.0 RAPGEF1 -0.021 0.144 0.235 4.0 -0.373 34.0 38.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.159 -9999.0 0.0 -0.425 37.0 37.0 CRK -0.036 0.142 -9999.0 0.0 -0.396 35.0 35.0 E-cadherin/gamma catenin/alpha catenin -0.004 0.11 -9999.0 0.0 -0.272 34.0 34.0 alphaE/beta7 Integrin 0.017 0.079 -9999.0 0.0 -0.321 13.0 13.0 IQGAP1 0.024 0.017 -9999.0 0.0 -0.131 3.0 3.0 NCKAP1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.039 0.027 -9999.0 0.0 -0.246 1.0 1.0 DLG1 -0.034 0.151 -9999.0 0.0 -0.418 35.0 35.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.048 -9999.0 0.0 -0.152 1.0 1.0 MLLT4 0.023 0.029 -9999.0 0.0 -0.449 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.017 0.062 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.023 0.121 -9999.0 0.0 -0.321 34.0 34.0 TIAM1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.027 0.094 -9999.0 0.0 -0.232 30.0 30.0 AKT1 -0.003 0.047 0.141 1.0 -9999.0 0.0 1.0 PIK3R1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.052 0.157 -9999.0 0.0 -0.288 67.0 67.0 RhoA/GDP 0.002 0.108 0.254 4.0 -0.262 31.0 35.0 actin cytoskeleton organization 0.013 0.062 0.164 10.0 -0.151 2.0 12.0 CDC42/GDP -0.003 0.104 0.242 2.0 -0.258 30.0 32.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.079 -9999.0 0.0 -0.223 33.0 33.0 ITGB7 -0.002 0.104 -9999.0 0.0 -0.328 21.0 21.0 RAC1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.029 0.1 -9999.0 0.0 -0.247 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.012 0.092 -9999.0 0.0 -0.23 33.0 33.0 mol:GDP -0.014 0.119 0.256 5.0 -0.299 32.0 37.0 CDC42/GTP/IQGAP1 0.028 0.017 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.024 0.029 -9999.0 0.0 -0.449 1.0 1.0 p120 catenin/RhoA/GDP 0.008 0.11 0.261 3.0 -0.27 29.0 32.0 RAC1/GTP/IQGAP1 0.03 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.012 0.053 0.141 10.0 -0.191 6.0 16.0 NME1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.153 -9999.0 0.0 -0.419 36.0 36.0 regulation of cell-cell adhesion -0.01 0.059 -9999.0 0.0 -0.171 3.0 3.0 WASF2 0.009 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.0 0.087 0.235 1.0 -0.213 4.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.024 0.131 -9999.0 0.0 -0.277 40.0 40.0 CCND1 0.013 0.062 0.157 9.0 -0.237 6.0 15.0 VAV2 -0.015 0.155 -9999.0 0.0 -0.409 29.0 29.0 RAP1/GDP 0.006 0.096 0.249 1.0 -0.228 29.0 30.0 adherens junction assembly -0.034 0.149 -9999.0 0.0 -0.406 36.0 36.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.011 0.122 -9999.0 0.0 -0.267 40.0 40.0 E-cadherin/beta catenin -0.033 0.11 -9999.0 0.0 -0.331 32.0 32.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.036 0.151 -9999.0 0.0 -0.415 36.0 36.0 PIK3CA 0.024 0.029 -9999.0 0.0 -0.449 1.0 1.0 Rac1/GTP -0.02 0.085 -9999.0 0.0 -0.305 3.0 3.0 E-cadherin/beta catenin/alpha catenin -0.003 0.108 -9999.0 0.0 -0.272 33.0 33.0 ITGAE 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.032 0.162 -9999.0 0.0 -0.434 37.0 37.0