Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.192 -9999.0 0.0 -0.604 25.0 25.0 IHH 0.015 0.052 -9999.0 0.0 -0.18 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.008 0.087 0.15 8.0 -0.248 27.0 35.0 LRPAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.008 0.086 0.247 27.0 -0.148 8.0 35.0 SMO/beta Arrestin2 -0.001 0.115 -9999.0 0.0 -0.439 10.0 10.0 SMO -0.013 0.113 -9999.0 0.0 -0.423 13.0 13.0 AKT1 -0.0 0.113 -9999.0 0.0 -0.488 10.0 10.0 ARRB2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.021 0.043 -9999.0 0.0 -0.449 2.0 2.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.013 0.112 -9999.0 0.0 -0.417 13.0 13.0 STIL -0.01 0.13 0.217 1.0 -0.297 25.0 26.0 DHH N/PTCH2 0.011 0.074 -9999.0 0.0 -0.319 11.0 11.0 DHH N/PTCH1 -0.011 0.125 -9999.0 0.0 -0.317 33.0 33.0 PIK3CA 0.024 0.029 -9999.0 0.0 -0.449 1.0 1.0 DHH -0.002 0.099 -9999.0 0.0 -0.271 25.0 25.0 PTHLH -0.056 0.259 -9999.0 0.0 -0.825 25.0 25.0 determination of left/right symmetry -0.013 0.112 -9999.0 0.0 -0.417 13.0 13.0 PIK3R1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.055 0.255 -9999.0 0.0 -0.814 25.0 25.0 IHH N/Hhip -0.05 0.145 -9999.0 0.0 -0.356 44.0 44.0 DHH N/Hhip -0.056 0.145 -9999.0 0.0 -0.322 55.0 55.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.013 0.112 -9999.0 0.0 -0.417 13.0 13.0 pancreas development -0.07 0.173 -9999.0 0.0 -0.311 76.0 76.0 HHAT 0.016 0.066 -9999.0 0.0 -0.449 5.0 5.0 PI3K 0.037 0.023 -9999.0 0.0 -0.321 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.013 0.054 -9999.0 0.0 -0.449 2.0 2.0 somite specification -0.013 0.112 -9999.0 0.0 -0.417 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.029 0.116 -9999.0 0.0 -0.27 45.0 45.0 SHH Np/Cholesterol/PTCH2 -0.014 0.082 -9999.0 0.0 -0.251 27.0 27.0 SHH Np/Cholesterol/Megalin -0.057 0.125 0.148 1.0 -0.294 50.0 51.0 SHH -0.027 0.1 -9999.0 0.0 -0.324 26.0 26.0 catabolic process -0.013 0.116 -9999.0 0.0 -0.356 24.0 24.0 SMO/Vitamin D3 -0.027 0.119 -9999.0 0.0 -0.348 19.0 19.0 SHH Np/Cholesterol/Hhip -0.055 0.126 -9999.0 0.0 -0.291 52.0 52.0 LRP2 -0.083 0.18 -9999.0 0.0 -0.301 90.0 90.0 receptor-mediated endocytosis -0.056 0.144 -9999.0 0.0 -0.416 24.0 24.0 SHH Np/Cholesterol/BOC -0.012 0.084 -9999.0 0.0 -0.25 28.0 28.0 SHH Np/Cholesterol/CDO -0.016 0.088 -9999.0 0.0 -0.256 29.0 29.0 mesenchymal cell differentiation 0.055 0.125 0.29 52.0 -9999.0 0.0 52.0 mol:Vitamin D3 0.0 0.142 0.204 1.0 -0.297 31.0 32.0 IHH N/PTCH2 0.025 0.043 -9999.0 0.0 -0.259 2.0 2.0 CDON 0.005 0.091 -9999.0 0.0 -0.449 10.0 10.0 IHH N/PTCH1 -0.007 0.119 -9999.0 0.0 -0.359 24.0 24.0 Megalin/LRPAP1 -0.045 0.136 -9999.0 0.0 -0.32 48.0 48.0 PTCH2 0.019 0.033 -9999.0 0.0 -0.237 3.0 3.0 SHH Np/Cholesterol -0.016 0.078 0.198 1.0 -0.247 26.0 27.0 PTCH1 -0.013 0.116 -9999.0 0.0 -0.358 24.0 24.0 HHIP -0.07 0.173 -9999.0 0.0 -0.311 76.0 76.0