Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.013 0.088 -9999.0 0.0 -0.229 36.0 36.0 epithelial cell differentiation 0.022 0.091 -9999.0 0.0 -0.23 30.0 30.0 CYFIP2 0.023 0.032 -9999.0 0.0 -0.449 1.0 1.0 ENAH -0.025 0.065 0.271 3.0 -9999.0 0.0 3.0 EGFR -0.009 0.115 -9999.0 0.0 -0.449 17.0 17.0 EPHA2 0.012 0.046 -9999.0 0.0 -0.449 1.0 1.0 MYO6 -0.018 0.08 0.178 7.0 -0.221 30.0 37.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.026 -9999.0 0.0 -0.249 1.0 1.0 AQP5 -0.063 0.161 -9999.0 0.0 -0.454 32.0 32.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.017 0.079 0.176 8.0 -0.219 29.0 37.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.085 0.176 8.0 -0.224 33.0 41.0 EGF -0.001 0.101 -9999.0 0.0 -0.313 21.0 21.0 NCKAP1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.029 0.123 -9999.0 0.0 -0.503 12.0 12.0 cortical microtubule organization 0.022 0.091 -9999.0 0.0 -0.23 30.0 30.0 GO:0000145 -0.03 0.071 0.165 8.0 -0.209 29.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.094 -9999.0 0.0 -0.232 30.0 30.0 MLLT4 0.023 0.029 -9999.0 0.0 -0.449 1.0 1.0 ARF6/GDP -0.039 0.059 -9999.0 0.0 -0.205 18.0 18.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.054 0.034 -9999.0 0.0 -0.248 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.031 0.087 0.175 1.0 -0.267 24.0 25.0 PVRL2 0.02 0.03 -9999.0 0.0 -0.449 1.0 1.0 ZYX -0.016 0.07 0.178 3.0 -0.222 24.0 27.0 ARF6/GTP 0.059 0.036 -9999.0 0.0 -0.232 1.0 1.0 CDH1 -0.052 0.157 -9999.0 0.0 -0.288 67.0 67.0 EGFR/EGFR/EGF/EGF -0.018 0.116 -9999.0 0.0 -0.244 51.0 51.0 RhoA/GDP 0.024 0.088 -9999.0 0.0 -0.219 30.0 30.0 actin cytoskeleton organization -0.032 0.074 0.166 7.0 -0.219 30.0 37.0 IGF-1R heterotetramer 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.012 0.073 -9999.0 0.0 -0.29 12.0 12.0 DIAPH1 0.028 0.106 -9999.0 0.0 -0.626 2.0 2.0 Wnt receptor signaling pathway -0.022 0.091 0.23 30.0 -9999.0 0.0 30.0 RHOA 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.039 0.059 -9999.0 0.0 -0.206 18.0 18.0 CTNNA1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.032 0.075 0.168 7.0 -0.223 30.0 37.0 EFNA1 0.025 0.011 -9999.0 0.0 -0.131 1.0 1.0 LPP -0.041 0.079 0.171 6.0 -0.221 36.0 42.0 Ephrin A1/EPHA2 0.013 0.083 -9999.0 0.0 -0.211 30.0 30.0 SEC6/SEC8 -0.017 0.066 -9999.0 0.0 -0.224 14.0 14.0 MGAT3 -0.021 0.087 0.178 8.0 -0.227 33.0 41.0 HGF/MET -0.023 0.121 -9999.0 0.0 -0.255 49.0 49.0 HGF -0.005 0.082 -9999.0 0.0 -0.189 33.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.089 -9999.0 0.0 -0.23 36.0 36.0 actin cable formation -0.003 0.103 0.351 8.0 -0.252 5.0 13.0 KIAA1543 -0.034 0.073 0.167 4.0 -0.22 30.0 34.0 KIFC3 -0.019 0.084 0.178 8.0 -0.229 30.0 38.0 NCK1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.024 0.081 0.178 6.0 -0.223 31.0 37.0 NCK1/GIT1 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.022 0.091 -9999.0 0.0 -0.23 30.0 30.0 EXOC4 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.018 0.082 0.178 8.0 -0.222 30.0 38.0 PIP5K1C -0.017 0.08 0.178 8.0 -0.222 29.0 37.0 LIMA1 0.015 0.07 -9999.0 0.0 -0.449 6.0 6.0 ABI1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.021 0.09 0.389 5.0 -0.223 1.0 6.0 adherens junction assembly -0.013 0.087 0.29 3.0 -0.385 3.0 6.0 IGF-1R heterotetramer/IGF1 0.013 0.093 -9999.0 0.0 -0.226 34.0 34.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.034 -9999.0 0.0 -0.321 2.0 2.0 MET -0.045 0.14 -9999.0 0.0 -0.449 25.0 25.0 PLEKHA7 -0.021 0.082 0.18 5.0 -0.23 30.0 35.0 mol:GTP 0.052 0.033 -9999.0 0.0 -0.247 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.012 0.115 0.313 14.0 -0.308 2.0 16.0 cortical actin cytoskeleton stabilization -0.013 0.088 -9999.0 0.0 -0.229 36.0 36.0 regulation of cell-cell adhesion -0.032 0.074 0.166 7.0 -0.219 30.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.089 -9999.0 0.0 -0.23 36.0 36.0