Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.068 0.148 -9999.0 0.0 -0.253 9.0 9.0 epithelial cell differentiation -0.034 0.148 -9999.0 0.0 -0.233 9.0 9.0 CYFIP2 0.03 0.032 -9999.0 0.0 -0.128 1.0 1.0 ENAH -0.052 0.091 -9999.0 0.0 -0.395 1.0 1.0 EGFR -0.005 0.122 -9999.0 0.0 -0.323 3.0 3.0 EPHA2 0.024 0.033 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.072 0.147 -9999.0 0.0 -0.245 9.0 9.0 CTNNB1 0.002 0.12 -9999.0 0.0 -0.421 2.0 2.0 ABI1/Sra1/Nap1 0.06 0.037 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.045 0.115 -9999.0 0.0 -0.377 1.0 1.0 CTNND1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.063 0.124 -9999.0 0.0 -0.221 9.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.064 0.121 0.188 1.0 -0.217 9.0 10.0 EGF 0.022 0.044 -9999.0 0.0 -0.128 2.0 2.0 NCKAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.054 0.136 -9999.0 0.0 -0.409 2.0 2.0 cortical microtubule organization -0.034 0.148 -9999.0 0.0 -0.233 9.0 9.0 GO:0000145 -0.067 0.113 0.172 1.0 -0.211 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.03 0.152 -9999.0 0.0 -0.235 9.0 9.0 MLLT4 0.018 0.087 -9999.0 0.0 -0.421 1.0 1.0 ARF6/GDP -0.072 0.099 -9999.0 0.0 -0.289 2.0 2.0 ARF6 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.073 0.04 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.068 0.112 -9999.0 0.0 -0.301 3.0 3.0 PVRL2 0.012 0.086 -9999.0 0.0 -0.421 1.0 1.0 ZYX -0.06 0.127 -9999.0 0.0 -0.224 9.0 9.0 ARF6/GTP 0.078 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.135 0.196 -9999.0 0.0 -0.295 14.0 14.0 EGFR/EGFR/EGF/EGF -0.062 0.139 -9999.0 0.0 -0.221 11.0 11.0 RhoA/GDP -0.033 0.164 -9999.0 0.0 -0.241 9.0 9.0 actin cytoskeleton organization -0.073 0.139 0.177 1.0 -0.238 9.0 10.0 IGF-1R heterotetramer 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.02 0.087 -9999.0 0.0 -0.421 1.0 1.0 DIAPH1 0.029 0.153 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.034 0.148 0.233 9.0 -9999.0 0.0 9.0 RHOA 0.018 0.087 -9999.0 0.0 -0.421 1.0 1.0 RhoA/GTP -0.077 0.121 -9999.0 0.0 -0.55 1.0 1.0 CTNNA1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.075 0.143 0.178 1.0 -0.244 9.0 10.0 EFNA1 0.031 0.031 -9999.0 0.0 -0.128 1.0 1.0 LPP -0.062 0.103 0.181 1.0 -0.209 2.0 3.0 Ephrin A1/EPHA2 -0.034 0.139 -9999.0 0.0 -0.217 9.0 9.0 SEC6/SEC8 -0.075 0.128 -9999.0 0.0 -0.316 3.0 3.0 MGAT3 -0.065 0.122 -9999.0 0.0 -0.22 9.0 9.0 HGF/MET -0.047 0.135 -9999.0 0.0 -0.222 9.0 9.0 HGF 0.015 0.052 -9999.0 0.0 -0.128 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.068 0.149 -9999.0 0.0 -0.255 9.0 9.0 actin cable formation -0.036 0.085 -9999.0 0.0 -0.262 1.0 1.0 KIAA1543 -0.076 0.104 -9999.0 0.0 -0.212 9.0 9.0 KIFC3 -0.065 0.125 -9999.0 0.0 -0.224 9.0 9.0 NCK1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.069 0.123 -9999.0 0.0 -0.224 9.0 9.0 NCK1/GIT1 0.054 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.034 0.148 -9999.0 0.0 -0.233 9.0 9.0 EXOC4 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.065 0.125 -9999.0 0.0 -0.224 9.0 9.0 PIP5K1C -0.063 0.126 -9999.0 0.0 -0.224 9.0 9.0 LIMA1 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.065 0.109 -9999.0 0.0 -0.474 1.0 1.0 adherens junction assembly -0.042 0.124 0.301 1.0 -0.294 2.0 3.0 IGF-1R heterotetramer/IGF1 -0.038 0.158 -9999.0 0.0 -0.238 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.091 -9999.0 0.0 -0.297 2.0 2.0 MET 0.027 0.033 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.072 0.115 -9999.0 0.0 -0.222 9.0 9.0 mol:GTP 0.071 0.038 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.04 0.159 0.294 1.0 -0.497 1.0 2.0 cortical actin cytoskeleton stabilization -0.068 0.148 -9999.0 0.0 -0.253 9.0 9.0 regulation of cell-cell adhesion -0.073 0.139 0.177 1.0 -0.238 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.068 0.149 -9999.0 0.0 -0.255 9.0 9.0