Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	307.0	51.0	-0.761	0.037	1000.0	-1000.0	-0.081	-1000.0
E-cadherin signaling events	6.0	34.0	5.0	-0.135	0.037	1000.0	-1000.0	0.014	-1000.0
Ephrin A  reverse signaling	5.0	38.0	7.0	-0.105	0.004	1000.0	-1000.0	-0.0	-1000.0
Thromboxane A2 receptor signaling	4.0	473.0	105.0	-0.236	0.06	1000.0	-1000.0	-0.032	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	287.0	68.0	-0.5	0.317	1000.0	-1000.0	-0.053	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	323.0	74.0	-0.135	0.078	1000.0	-1000.0	-0.058	-1000.0
IL23-mediated signaling events	4.0	288.0	60.0	-0.654	0.039	1000.0	-1000.0	-0.063	-1000.0
IL12-mediated signaling events	3.0	286.0	87.0	-0.41	0.075	1000.0	-1000.0	-0.046	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	-0.037	-1000.0	1000.0	-1000.0	0.004	-1000.0
Osteopontin-mediated events	3.0	115.0	38.0	-0.107	0.037	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by the Hedgehog family	3.0	172.0	52.0	-0.133	0.062	1000.0	-1000.0	-0.029	-1000.0
Ephrin B reverse signaling	3.0	165.0	48.0	-0.106	0.041	1000.0	-1000.0	-0.036	-1000.0
Endothelins	3.0	340.0	96.0	-0.33	0.048	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	255.0	76.0	-0.148	0.058	1000.0	-1000.0	-0.055	-1000.0
TCGA08_retinoblastoma	3.0	30.0	8.0	-0.053	0.084	1000.0	-1000.0	-0.005	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	281.0	136.0	-0.435	0.097	1000.0	-1000.0	-0.035	-1000.0
Syndecan-1-mediated signaling events	2.0	85.0	34.0	-0.183	0.037	1000.0	-1000.0	-0.015	-1000.0
Visual signal transduction: Cones	2.0	82.0	38.0	-0.064	0.043	1000.0	-1000.0	-0.0	-1000.0
HIF-1-alpha transcription factor network	2.0	193.0	76.0	-0.209	0.065	1000.0	-1000.0	-0.03	-1000.0
Arf6 signaling events	2.0	150.0	62.0	-0.055	0.08	1000.0	-1000.0	-0.012	-1000.0
PLK1 signaling events	2.0	223.0	85.0	-0.146	0.054	1000.0	-1000.0	-0.028	-1000.0
PDGFR-alpha signaling pathway	2.0	110.0	44.0	-0.236	0.046	1000.0	-1000.0	-0.022	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	165.0	82.0	-0.058	0.054	1000.0	-1000.0	-0.049	-1000.0
Syndecan-3-mediated signaling events	2.0	94.0	35.0	-0.105	0.082	1000.0	-1000.0	-0.017	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	69.0	31.0	-0.108	0.043	1000.0	-1000.0	-0.041	-1000.0
Nongenotropic Androgen signaling	2.0	131.0	52.0	-0.202	0.102	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	368.0	125.0	-0.083	0.09	1000.0	-1000.0	-0.034	-1000.0
Wnt signaling	2.0	14.0	7.0	-0.022	0.036	1000.0	-1000.0	0.001	-1000.0
IL6-mediated signaling events	2.0	154.0	75.0	-0.151	0.061	1000.0	-1000.0	-0.053	-1000.0
BCR signaling pathway	2.0	210.0	99.0	-0.099	0.056	1000.0	-1000.0	-0.056	-1000.0
Syndecan-4-mediated signaling events	2.0	163.0	67.0	-0.101	0.049	1000.0	-1000.0	-0.029	-1000.0
Aurora B signaling	2.0	149.0	67.0	-0.173	0.055	1000.0	-1000.0	-0.041	-1000.0
Caspase cascade in apoptosis	1.0	130.0	74.0	-0.071	0.042	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	1.0	81.0	76.0	-0.082	0.065	1000.0	-1000.0	-0.034	-1000.0
ErbB4 signaling events	1.0	70.0	69.0	-0.116	0.056	1000.0	-1000.0	-0.029	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	28.0	28.0	-0.037	0.051	1000.0	-1000.0	-0.011	-1000.0
Noncanonical Wnt signaling pathway	1.0	41.0	26.0	-0.024	0.036	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	1.0	88.0	69.0	-0.064	0.054	1000.0	-1000.0	-0.036	-1000.0
Cellular roles of Anthrax toxin	1.0	66.0	39.0	-0.171	0.038	1000.0	-1000.0	-0.022	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	81.0	61.0	-0.175	0.082	1000.0	-1000.0	-0.057	-1000.0
Aurora A signaling	1.0	66.0	60.0	-0.089	0.092	1000.0	-1000.0	-0.011	-1000.0
p75(NTR)-mediated signaling	1.0	153.0	125.0	-0.183	0.082	1000.0	-1000.0	-0.023	-1000.0
IL4-mediated signaling events	1.0	126.0	91.0	-0.513	0.26	1000.0	-1000.0	-0.096	-1000.0
BMP receptor signaling	1.0	125.0	81.0	-0.064	0.074	1000.0	-1000.0	-0.025	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	159.0	97.0	-0.107	0.063	1000.0	-1000.0	-0.06	-1000.0
amb2 Integrin signaling	1.0	107.0	82.0	-0.082	0.053	1000.0	-1000.0	-0.014	-1000.0
Nectin adhesion pathway	1.0	84.0	63.0	-0.135	0.074	1000.0	-1000.0	-0.044	-1000.0
Glucocorticoid receptor regulatory network	1.0	120.0	114.0	-0.267	0.086	1000.0	-1000.0	-0.046	-1000.0
Ceramide signaling pathway	1.0	113.0	76.0	-0.076	0.064	1000.0	-1000.0	-0.022	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	45.0	37.0	-0.093	0.069	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class III	1.0	63.0	40.0	-0.135	0.095	1000.0	-1000.0	-0.03	-1000.0
TRAIL signaling pathway	1.0	56.0	48.0	-0.001	0.063	1000.0	-1000.0	-0.032	-1000.0
IL1-mediated signaling events	1.0	117.0	62.0	-0.103	0.063	1000.0	-1000.0	-0.015	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	64.0	52.0	-0.248	0.108	1000.0	-1000.0	-0.028	-1000.0
S1P1 pathway	1.0	54.0	36.0	-0.094	0.037	1000.0	-1000.0	-0.028	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.042	0.036	1000.0	-1000.0	-0.007	-1000.0
FAS signaling pathway (CD95)	1.0	66.0	47.0	-0.046	0.052	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	75.0	44.0	-0.061	0.036	1000.0	-1000.0	-0.01	-1000.0
Integrins in angiogenesis	1.0	118.0	84.0	-0.079	0.088	1000.0	-1000.0	-0.032	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	51.0	45.0	-0.027	0.062	1000.0	-1000.0	-0.044	-1000.0
Canonical Wnt signaling pathway	1.0	59.0	51.0	-0.175	0.082	1000.0	-1000.0	-0.035	-1000.0
EPHB forward signaling	1.0	126.0	85.0	-0.056	0.083	1000.0	-1000.0	-0.039	-1000.0
Effects of Botulinum toxin	1.0	37.0	26.0	-0.152	0.051	1000.0	-1000.0	-0.0	-1000.0
Glypican 2 network	1.0	6.0	4.0	0.0	0.018	1000.0	-1000.0	0.0	-1000.0
LPA receptor mediated events	1.0	107.0	102.0	-0.154	0.059	1000.0	-1000.0	-0.061	-1000.0
Class I PI3K signaling events	1.0	84.0	73.0	-0.061	0.07	1000.0	-1000.0	-0.029	-1000.0
EGFR-dependent Endothelin signaling events	1.0	32.0	21.0	-0.027	0.068	1000.0	-1000.0	-0.03	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	125.0	88.0	-0.136	0.049	1000.0	-1000.0	-0.054	-1000.0
Rapid glucocorticoid signaling	1.0	28.0	20.0	-0.092	0.029	1000.0	-1000.0	-0.0	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	130.0	120.0	-0.154	0.108	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Rods	1.0	99.0	52.0	-0.064	0.049	1000.0	-1000.0	-0.0	-1000.0
Signaling events mediated by PRL	1.0	54.0	34.0	-0.164	0.049	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in keratinocytes	1.0	83.0	43.0	-0.134	0.041	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	138.0	78.0	-0.077	0.049	1000.0	-1000.0	-0.052	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	25.0	17.0	-0.043	0.04	1000.0	-1000.0	-0.016	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.049	0.012	1000.0	-1000.0	-0.008	-1000.0
ErbB2/ErbB3 signaling events	0.0	50.0	65.0	-0.065	0.053	1000.0	-1000.0	-0.062	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	-0.007	0.07	1000.0	-1000.0	-0.025	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	5.0	34.0	-0.046	0.085	1000.0	-1000.0	-0.03	-1000.0
Canonical NF-kappaB pathway	0.0	17.0	39.0	-0.027	0.079	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by HDAC Class II	0.0	26.0	75.0	-0.052	0.095	1000.0	-1000.0	-0.014	-1000.0
BARD1 signaling events	0.0	51.0	57.0	-0.065	0.074	1000.0	-1000.0	-0.046	-1000.0
Circadian rhythm pathway	0.0	16.0	22.0	-0.073	0.063	1000.0	-1000.0	-0.03	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	34.0	54.0	-0.022	0.082	1000.0	-1000.0	-0.011	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	4.0	17.0	-0.0	0.068	1000.0	-1000.0	-0.019	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.013	0.036	1000.0	-1000.0	0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	60.0	85.0	-0.296	0.095	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by PTP1B	0.0	72.0	76.0	-0.034	0.062	1000.0	-1000.0	-0.04	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	46.0	65.0	-0.035	0.079	1000.0	-1000.0	-0.046	-1000.0
Arf6 downstream pathway	0.0	20.0	43.0	-0.054	0.069	1000.0	-1000.0	-0.032	-1000.0
Aurora C signaling	0.0	1.0	7.0	-0.0	0.039	1000.0	-1000.0	-0.001	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	18.0	46.0	-0.035	0.059	1000.0	-1000.0	-0.072	-1000.0
Glypican 1 network	0.0	38.0	48.0	-0.038	0.068	1000.0	-1000.0	-0.023	-1000.0
EPO signaling pathway	0.0	19.0	55.0	-0.0	0.094	1000.0	-1000.0	-0.028	-1000.0
Insulin-mediated glucose transport	0.0	9.0	32.0	-0.0	0.076	1000.0	-1000.0	-0.017	-1000.0
mTOR signaling pathway	0.0	25.0	53.0	-0.05	0.066	1000.0	-1000.0	-0.042	-1000.0
IFN-gamma pathway	0.0	39.0	68.0	-0.063	0.061	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	25.0	68.0	-0.046	0.07	1000.0	-1000.0	-0.029	-1000.0
Reelin signaling pathway	0.0	28.0	56.0	-0.047	0.087	1000.0	-1000.0	-0.013	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.009	0.037	1000.0	-1000.0	-0.003	-1000.0
ceramide signaling pathway	0.0	42.0	49.0	-0.027	0.049	1000.0	-1000.0	-0.041	-1000.0
HIF-2-alpha transcription factor network	0.0	26.0	43.0	-0.124	0.127	1000.0	-1000.0	-0.042	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	46.0	83.0	-0.025	0.073	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class I	0.0	35.0	104.0	-0.072	0.079	1000.0	-1000.0	-0.033	-1000.0
FoxO family signaling	0.0	31.0	64.0	-0.1	0.066	1000.0	-1000.0	-0.035	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	12.0	15.0	-0.055	0.036	1000.0	-1000.0	-0.011	-1000.0
Retinoic acid receptors-mediated signaling	0.0	22.0	58.0	-0.038	0.07	1000.0	-1000.0	-0.024	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	23.0	36.0	-0.093	0.07	1000.0	-1000.0	-0.033	-1000.0
Atypical NF-kappaB pathway	0.0	13.0	31.0	-0.009	0.051	1000.0	-1000.0	-0.009	-1000.0
IL2 signaling events mediated by PI3K	0.0	17.0	58.0	-0.014	0.064	1000.0	-1000.0	-0.042	-1000.0
TCR signaling in naïve CD8+ T cells	0.0	90.0	93.0	-0.108	0.127	1000.0	-1000.0	-0.04	-1000.0
Regulation of p38-alpha and p38-beta	0.0	35.0	54.0	-0.037	0.086	1000.0	-1000.0	-0.044	-1000.0
IL27-mediated signaling events	0.0	35.0	51.0	-0.099	0.067	1000.0	-1000.0	-0.053	-1000.0
TCGA08_rtk_signaling	0.0	23.0	26.0	-0.05	0.078	1000.0	-1000.0	-0.007	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	0.0	0.089	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by STAT5	0.0	9.0	22.0	-0.076	0.055	1000.0	-1000.0	-0.042	-1000.0
Arf6 trafficking events	0.0	19.0	71.0	-0.049	0.069	1000.0	-1000.0	-0.025	-1000.0
Regulation of Telomerase	0.0	87.0	102.0	-0.137	0.095	1000.0	-1000.0	-0.033	-1000.0
IGF1 pathway	0.0	15.0	57.0	-0.039	0.098	1000.0	-1000.0	-0.024	-1000.0
Insulin Pathway	0.0	38.0	74.0	-0.039	0.094	1000.0	-1000.0	-0.026	-1000.0
Plasma membrane estrogen receptor signaling	0.0	75.0	86.0	-0.051	0.054	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	0.0	15.0	56.0	-0.016	0.081	1000.0	-1000.0	-0.025	-1000.0
S1P3 pathway	0.0	18.0	42.0	-0.04	0.055	1000.0	-1000.0	-0.032	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	7.0	33.0	-0.051	0.091	1000.0	-1000.0	-0.029	-1000.0
PDGFR-beta signaling pathway	0.0	65.0	97.0	-0.04	0.103	1000.0	-1000.0	-0.034	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.035	0.035	1000.0	-1000.0	-0.021	-1000.0
S1P4 pathway	0.0	3.0	25.0	-0.0	0.051	1000.0	-1000.0	-0.011	-1000.0
p38 MAPK signaling pathway	0.0	36.0	44.0	-0.044	0.067	1000.0	-1000.0	-0.015	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.001	0.051	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	-0.0	0.07	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	36.0	70.0	-0.186	0.064	1000.0	-1000.0	-0.047	-1000.0
Total	134	10758	7203	-13.7125304319	-991.192030987	131000	-131000	-3.80731462003	-131000