Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.038 0.252 0.628 4.0 -0.792 5.0 9.0 IHH -0.0 0.226 0.391 6.0 -0.863 7.0 13.0 SHH Np/Cholesterol/GAS1 -0.11 0.248 -9999.0 0.0 -0.617 24.0 24.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.108 0.245 0.611 24.0 -9999.0 0.0 24.0 SMO/beta Arrestin2 -0.012 0.238 -9999.0 0.0 -0.713 11.0 11.0 SMO -0.012 0.257 0.341 3.0 -0.762 11.0 14.0 AKT1 0.002 0.172 -9999.0 0.0 -1.589 1.0 1.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.053 0.358 3.0 -9999.0 0.0 3.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.25 0.34 3.0 -0.742 11.0 14.0 STIL 0.019 0.219 0.345 8.0 -0.514 14.0 22.0 DHH N/PTCH2 -0.002 0.066 -9999.0 0.0 -0.685 1.0 1.0 DHH N/PTCH1 0.001 0.216 0.344 5.0 -0.649 10.0 15.0 PIK3CA -0.007 0.076 -9999.0 0.0 -0.879 1.0 1.0 DHH 0.003 0.031 0.358 1.0 -9999.0 0.0 1.0 PTHLH 0.043 0.272 0.611 4.0 -0.832 5.0 9.0 determination of left/right symmetry -0.011 0.25 0.34 3.0 -0.742 11.0 14.0 PIK3R1 -0.007 0.076 -9999.0 0.0 -0.879 1.0 1.0 skeletal system development 0.043 0.27 0.61 4.0 -0.822 5.0 9.0 IHH N/Hhip -0.383 0.401 -9999.0 0.0 -0.749 71.0 71.0 DHH N/Hhip -0.345 0.348 -9999.0 0.0 -0.686 68.0 68.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.25 0.34 3.0 -0.742 11.0 14.0 pancreas development -0.443 0.442 0.357 1.0 -0.877 68.0 69.0 HHAT 0.005 0.043 0.358 2.0 -9999.0 0.0 2.0 PI3K -0.009 0.106 -9999.0 0.0 -1.234 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.144 0.326 -9999.0 0.0 -0.879 22.0 22.0 somite specification -0.011 0.25 0.34 3.0 -0.742 11.0 14.0 SHH Np/Cholesterol/PTCH1 -0.014 0.214 -9999.0 0.0 -0.56 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.021 0.118 -9999.0 0.0 -0.554 6.0 6.0 SHH Np/Cholesterol/Megalin -0.093 0.233 -9999.0 0.0 -0.555 26.0 26.0 SHH -0.023 0.133 -9999.0 0.0 -0.687 5.0 5.0 catabolic process 0.026 0.242 0.404 5.0 -0.684 11.0 16.0 SMO/Vitamin D3 -0.011 0.248 0.358 4.0 -0.613 15.0 19.0 SHH Np/Cholesterol/Hhip -0.299 0.294 -9999.0 0.0 -0.569 71.0 71.0 LRP2 -0.116 0.339 0.358 8.0 -0.879 21.0 29.0 receptor-mediated endocytosis -0.066 0.261 0.327 1.0 -0.688 13.0 14.0 SHH Np/Cholesterol/BOC -0.014 0.112 -9999.0 0.0 -0.554 5.0 5.0 SHH Np/Cholesterol/CDO -0.019 0.106 -9999.0 0.0 -0.554 5.0 5.0 mesenchymal cell differentiation 0.296 0.291 0.564 71.0 -9999.0 0.0 71.0 mol:Vitamin D3 -0.005 0.225 0.359 4.0 -0.562 14.0 18.0 IHH N/PTCH2 -0.009 0.161 0.258 2.0 -0.596 8.0 10.0 CDON 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.017 0.255 0.462 5.0 -0.691 11.0 16.0 Megalin/LRPAP1 -0.093 0.262 -9999.0 0.0 -0.685 21.0 21.0 PTCH2 -0.004 0.082 0.358 1.0 -0.879 1.0 2.0 SHH Np/Cholesterol -0.018 0.11 -9999.0 0.0 -0.561 5.0 5.0 PTCH1 0.026 0.244 0.405 5.0 -0.688 11.0 16.0 HHIP -0.443 0.443 0.358 1.0 -0.879 68.0 69.0