Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.432 0.296 -9999.0 0.0 -0.693 225.0 225.0 IHH -0.47 0.385 -9999.0 0.0 -0.811 269.0 269.0 SHH Np/Cholesterol/GAS1 -0.071 0.166 -9999.0 0.0 -0.456 71.0 71.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.071 0.165 0.453 71.0 -9999.0 0.0 71.0 SMO/beta Arrestin2 -0.362 0.251 -9999.0 0.0 -0.594 232.0 232.0 SMO -0.381 0.272 -9999.0 0.0 -0.63 233.0 233.0 AKT1 -0.151 0.109 -9999.0 0.0 -0.341 1.0 1.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.005 0.06 -9999.0 0.0 -0.656 4.0 4.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.375 0.267 -9999.0 0.0 -0.618 233.0 233.0 STIL -0.329 0.248 -9999.0 0.0 -0.703 84.0 84.0 DHH N/PTCH2 -0.046 0.155 -9999.0 0.0 -0.563 39.0 39.0 DHH N/PTCH1 -0.364 0.244 -9999.0 0.0 -0.576 238.0 238.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.052 0.19 -9999.0 0.0 -0.741 34.0 34.0 PTHLH -0.581 0.357 -9999.0 0.0 -0.918 225.0 225.0 determination of left/right symmetry -0.375 0.267 -9999.0 0.0 -0.618 233.0 233.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.574 0.35 -9999.0 0.0 -0.905 225.0 225.0 IHH N/Hhip -0.654 0.378 -9999.0 0.0 -0.821 383.0 383.0 DHH N/Hhip -0.408 0.295 -9999.0 0.0 -0.596 330.0 330.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.375 0.267 -9999.0 0.0 -0.618 233.0 233.0 pancreas development -0.494 0.348 -9999.0 0.0 -0.739 322.0 322.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.012 0.095 -9999.0 0.0 -0.741 8.0 8.0 somite specification -0.375 0.267 -9999.0 0.0 -0.618 233.0 233.0 SHH Np/Cholesterol/PTCH1 -0.352 0.252 -9999.0 0.0 -0.558 248.0 248.0 SHH Np/Cholesterol/PTCH2 -0.069 0.159 -9999.0 0.0 -0.431 77.0 77.0 SHH Np/Cholesterol/Megalin -0.288 0.269 -9999.0 0.0 -0.5 276.0 276.0 SHH -0.066 0.202 -9999.0 0.0 -0.546 72.0 72.0 catabolic process -0.372 0.253 -9999.0 0.0 -0.571 278.0 278.0 SMO/Vitamin D3 -0.372 0.266 -9999.0 0.0 -0.593 248.0 248.0 SHH Np/Cholesterol/Hhip -0.357 0.26 -9999.0 0.0 -0.503 342.0 342.0 LRP2 -0.38 0.37 -9999.0 0.0 -0.741 247.0 247.0 receptor-mediated endocytosis -0.499 0.312 -9999.0 0.0 -0.718 281.0 281.0 SHH Np/Cholesterol/BOC -0.067 0.16 -9999.0 0.0 -0.451 66.0 66.0 SHH Np/Cholesterol/CDO -0.069 0.158 -9999.0 0.0 -0.429 77.0 77.0 mesenchymal cell differentiation 0.354 0.257 0.498 342.0 -9999.0 0.0 342.0 mol:Vitamin D3 -0.35 0.261 -9999.0 0.0 -0.563 248.0 248.0 IHH N/PTCH2 -0.306 0.269 -9999.0 0.0 -0.54 269.0 269.0 CDON -0.008 0.075 -9999.0 0.0 -0.741 5.0 5.0 IHH N/PTCH1 -0.377 0.257 -9999.0 0.0 -0.579 278.0 278.0 Megalin/LRPAP1 -0.286 0.279 -9999.0 0.0 -0.559 247.0 247.0 PTCH2 -0.009 0.076 -9999.0 0.0 -0.684 6.0 6.0 SHH Np/Cholesterol -0.065 0.156 -9999.0 0.0 -0.435 72.0 72.0 PTCH1 -0.373 0.254 -9999.0 0.0 -0.573 278.0 278.0 HHIP -0.495 0.349 -9999.0 0.0 -0.741 322.0 322.0