E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.01 0.091 -9999.0 0.0 -0.335 26.0 26.0 KLHL20 0.016 0.059 0.174 1.0 -0.25 9.0 10.0 CYFIP2 0.009 0.084 -9999.0 0.0 -0.561 10.0 10.0 Rac1/GDP 0.011 0.07 0.273 1.0 -9999.0 0.0 1.0 ENAH -0.01 0.096 -9999.0 0.0 -0.335 29.0 29.0 AP1M1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.015 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.037 -9999.0 0.0 -0.197 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.026 -9999.0 0.0 -0.329 1.0 1.0 RAPGEF1 -0.005 0.08 -9999.0 0.0 -0.323 1.0 1.0 CTNND1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.007 0.1 -9999.0 0.0 -0.342 29.0 29.0 CRK -0.004 0.073 -9999.0 0.0 -0.332 6.0 6.0 E-cadherin/gamma catenin/alpha catenin 0.043 0.014 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.031 0.022 -9999.0 0.0 -0.415 1.0 1.0 IQGAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.002 0.066 -9999.0 0.0 -0.336 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.007 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.041 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.009 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.049 0.018 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.004 0.031 0.133 1.0 -9999.0 0.0 1.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.016 0.066 0.272 1.0 -9999.0 0.0 1.0 actin cytoskeleton organization 0.015 0.048 0.168 5.0 -0.183 8.0 13.0 CDC42/GDP 0.014 0.069 0.253 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.022 0.027 -9999.0 0.0 -0.561 1.0 1.0 RAC1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.053 0.019 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.037 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.075 0.282 1.0 -9999.0 0.0 1.0 CDC42/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.022 0.065 0.272 1.0 -9999.0 0.0 1.0 RAC1/GTP/IQGAP1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.01 0.042 0.152 7.0 -0.24 6.0 13.0 NME1 0.023 0.01 0.239 1.0 -9999.0 0.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.092 -9999.0 0.0 -0.336 25.0 25.0 regulation of cell-cell adhesion 0.009 0.024 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.007 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.017 0.039 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.028 -9999.0 0.0 -0.313 1.0 1.0 CCND1 0.01 0.05 0.157 6.0 -0.303 6.0 12.0 VAV2 -0.013 0.126 -9999.0 0.0 -0.652 10.0 10.0 RAP1/GDP 0.019 0.054 0.247 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.007 0.09 -9999.0 0.0 -0.327 25.0 25.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.026 -9999.0 0.0 -0.304 1.0 1.0 E-cadherin/beta catenin 0.01 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.009 0.093 -9999.0 0.0 -0.336 25.0 25.0 PIK3CA 0.012 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.014 0.079 -9999.0 0.0 -0.411 11.0 11.0 E-cadherin/beta catenin/alpha catenin 0.042 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.007 0.101 -9999.0 0.0 -0.348 29.0 29.0