Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.032 0.06 0.336 7.0 -0.238 1.0 8.0 KIRREL 0.016 0.07 -9999.0 0.0 -0.558 7.0 7.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.032 0.06 0.239 1.0 -0.336 7.0 8.0 PLCG1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.05 0.055 0.325 1.0 -0.34 4.0 5.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.013 0.036 -9999.0 0.0 -0.301 2.0 2.0 FYN 0.009 0.078 0.281 17.0 -0.372 4.0 21.0 mol:Ca2+ 0.048 0.05 0.315 1.0 -0.285 3.0 4.0 mol:DAG 0.049 0.051 0.32 1.0 -0.286 3.0 4.0 NPHS2 -0.004 0.031 0.262 3.0 -9999.0 0.0 3.0 mol:IP3 0.049 0.051 0.32 1.0 -0.286 3.0 4.0 regulation of endocytosis 0.039 0.052 -9999.0 0.0 -0.345 4.0 4.0 Nephrin/NEPH1/podocin/Cholesterol 0.037 0.052 0.309 1.0 -0.342 4.0 5.0 establishment of cell polarity 0.032 0.06 0.238 1.0 -0.336 7.0 8.0 Nephrin/NEPH1/podocin/NCK1-2 0.051 0.057 0.323 1.0 -0.32 4.0 5.0 Nephrin/NEPH1/beta Arrestin2 0.042 0.054 -9999.0 0.0 -0.349 4.0 4.0 NPHS1 0.024 0.059 0.268 23.0 -9999.0 0.0 23.0 Nephrin/NEPH1/podocin 0.039 0.056 0.312 1.0 -0.373 4.0 5.0 TJP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.05 0.051 0.325 1.0 -0.287 3.0 4.0 CD2AP 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.049 0.054 0.325 1.0 -0.351 3.0 4.0 GRB2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.009 0.099 0.278 15.0 -0.364 18.0 33.0 cytoskeleton organization 0.004 0.042 0.197 1.0 -0.364 2.0 3.0 Nephrin/NEPH1 0.027 0.046 0.195 1.0 -0.315 4.0 5.0 Nephrin/NEPH1/ZO-1 0.041 0.053 -9999.0 0.0 -0.354 4.0 4.0