Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.16 0.234 -9999.0 0.0 -0.742 29.0 29.0 IHH -0.306 0.314 -9999.0 0.0 -0.589 261.0 261.0 SHH Np/Cholesterol/GAS1 -0.029 0.122 0.197 1.0 -0.328 66.0 67.0 LRPAP1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.029 0.121 0.326 66.0 -0.195 1.0 67.0 SMO/beta Arrestin2 -0.204 0.226 -9999.0 0.0 -0.399 249.0 249.0 SMO -0.22 0.229 -9999.0 0.0 -0.415 255.0 255.0 AKT1 -0.108 0.155 -9999.0 0.0 -0.571 30.0 30.0 ARRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.041 0.239 2.0 -0.561 2.0 4.0 ADRBK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.217 0.226 -9999.0 0.0 -0.41 255.0 255.0 STIL -0.175 0.188 -9999.0 0.0 -0.502 64.0 64.0 DHH N/PTCH2 -0.0 0.12 -9999.0 0.0 -0.404 37.0 37.0 DHH N/PTCH1 -0.182 0.208 -9999.0 0.0 -0.336 284.0 284.0 PIK3CA 0.012 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.15 -9999.0 0.0 -0.561 34.0 34.0 PTHLH -0.198 0.264 -9999.0 0.0 -0.745 28.0 28.0 determination of left/right symmetry -0.217 0.226 -9999.0 0.0 -0.41 255.0 255.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.197 0.262 -9999.0 0.0 -0.737 28.0 28.0 IHH N/Hhip -0.441 0.287 -9999.0 0.0 -0.577 370.0 370.0 DHH N/Hhip -0.278 0.23 -9999.0 0.0 -0.44 305.0 305.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.217 0.226 -9999.0 0.0 -0.41 255.0 255.0 pancreas development -0.338 0.281 -9999.0 0.0 -0.56 294.0 294.0 HHAT 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.07 -9999.0 0.0 -0.561 7.0 7.0 somite specification -0.217 0.226 -9999.0 0.0 -0.41 255.0 255.0 SHH Np/Cholesterol/PTCH1 -0.179 0.199 -9999.0 0.0 -0.391 136.0 136.0 SHH Np/Cholesterol/PTCH2 -0.026 0.118 0.197 1.0 -0.326 62.0 63.0 SHH Np/Cholesterol/Megalin -0.192 0.202 -9999.0 0.0 -0.363 261.0 261.0 SHH -0.06 0.134 0.298 1.0 -0.416 59.0 60.0 catabolic process -0.182 0.211 -9999.0 0.0 -0.355 271.0 271.0 SMO/Vitamin D3 -0.204 0.225 -9999.0 0.0 -0.384 255.0 255.0 SHH Np/Cholesterol/Hhip -0.234 0.195 -9999.0 0.0 -0.368 302.0 302.0 LRP2 -0.272 0.291 -9999.0 0.0 -0.561 241.0 241.0 receptor-mediated endocytosis -0.319 0.262 -9999.0 0.0 -0.58 201.0 201.0 SHH Np/Cholesterol/BOC -0.023 0.11 -9999.0 0.0 -0.328 52.0 52.0 SHH Np/Cholesterol/CDO -0.027 0.119 0.197 1.0 -0.325 64.0 65.0 mesenchymal cell differentiation 0.233 0.194 0.365 302.0 -9999.0 0.0 302.0 mol:Vitamin D3 -0.177 0.204 -9999.0 0.0 -0.466 85.0 85.0 IHH N/PTCH2 -0.187 0.207 -9999.0 0.0 -0.372 259.0 259.0 CDON 0.016 0.06 -9999.0 0.0 -0.561 5.0 5.0 IHH N/PTCH1 -0.176 0.223 -9999.0 0.0 -0.359 271.0 271.0 Megalin/LRPAP1 -0.192 0.222 -9999.0 0.0 -0.411 241.0 241.0 PTCH2 0.02 0.048 0.239 2.0 -0.561 3.0 5.0 SHH Np/Cholesterol -0.033 0.11 -9999.0 0.0 -0.323 59.0 59.0 PTCH1 -0.182 0.212 -9999.0 0.0 -0.356 271.0 271.0 HHIP -0.339 0.281 -9999.0 0.0 -0.561 294.0 294.0