Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.009 0.084 -9999.0 0.0 -0.561 10.0 10.0 ENAH 0.008 0.068 0.253 12.0 -9999.0 0.0 12.0 EGFR 0.022 0.084 0.367 11.0 -0.561 6.0 17.0 EPHA2 0.018 0.046 -9999.0 0.0 -0.561 3.0 3.0 MYO6 -0.008 0.025 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.033 0.057 -9999.0 0.0 -0.358 8.0 8.0 AQP5 -0.137 0.226 -9999.0 0.0 -0.484 140.0 140.0 CTNND1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.086 0.128 -9999.0 0.0 -0.293 129.0 129.0 EGF 0.015 0.072 0.239 3.0 -0.561 7.0 10.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.061 0.169 -9999.0 0.0 -0.476 65.0 65.0 cortical microtubule organization 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.009 0.022 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.049 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.019 0.023 -9999.0 0.0 -0.277 3.0 3.0 ARF6 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.039 -9999.0 0.0 -0.329 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.009 0.024 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.046 0.041 -9999.0 0.0 -0.309 3.0 3.0 CDH1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.031 0.062 -9999.0 0.0 -0.315 12.0 12.0 RhoA/GDP 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.005 0.102 0.239 1.0 -0.561 15.0 16.0 DIAPH1 -0.016 0.166 -9999.0 0.0 -0.574 21.0 21.0 Wnt receptor signaling pathway -0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.023 -9999.0 0.0 -0.275 3.0 3.0 CTNNA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.008 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.036 0.031 -9999.0 0.0 -0.295 3.0 3.0 SEC6/SEC8 -0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.087 0.13 -9999.0 0.0 -0.298 129.0 129.0 HGF/MET -0.025 0.13 -9999.0 0.0 -0.286 93.0 93.0 HGF -0.093 0.232 -9999.0 0.0 -0.561 94.0 94.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.046 0.1 0.319 25.0 -9999.0 0.0 25.0 KIAA1543 -0.01 0.02 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.01 0.024 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.018 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.009 0.025 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.028 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.017 0.086 0.297 19.0 -9999.0 0.0 19.0 adherens junction assembly -0.013 0.093 0.295 2.0 -0.71 6.0 8.0 IGF-1R heterotetramer/IGF1 0.03 0.057 -9999.0 0.0 -0.291 13.0 13.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.041 0.38 1.0 -0.561 2.0 3.0 PLEKHA7 -0.01 0.022 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.041 0.038 -9999.0 0.0 -0.327 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.022 0.083 0.343 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0