Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	159.0	14047.0	88.0	-0.715	0.076	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by the Hedgehog family	137.0	7132.0	52.0	-0.441	0.233	1000.0	-1000.0	-0.034	-1000.0
Endothelins	90.0	8700.0	96.0	-0.374	0.108	1000.0	-1000.0	-0.061	-1000.0
Fc-epsilon receptor I signaling in mast cells	61.0	5920.0	97.0	-0.146	0.023	1000.0	-1000.0	-0.061	-1000.0
Thromboxane A2 receptor signaling	59.0	6241.0	105.0	-0.201	0.056	1000.0	-1000.0	-0.039	-1000.0
Aurora B signaling	57.0	3827.0	67.0	-0.298	0.288	1000.0	-1000.0	-0.044	-1000.0
IL4-mediated signaling events	55.0	5024.0	91.0	-0.801	0.483	1000.0	-1000.0	-0.117	-1000.0
amb2 Integrin signaling	55.0	4520.0	82.0	-0.506	0.036	1000.0	-1000.0	-0.052	-1000.0
Signaling mediated by p38-alpha and p38-beta	54.0	2419.0	44.0	-0.106	0.022	1000.0	-1000.0	-0.033	-1000.0
TCGA08_retinoblastoma	54.0	433.0	8.0	-0.01	0.098	1000.0	-1000.0	-0.003	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	51.0	2672.0	52.0	-0.262	0.048	1000.0	-1000.0	-0.049	-1000.0
Aurora C signaling	49.0	349.0	7.0	-0.0	0.154	1000.0	-1000.0	-0.02	-1000.0
Signaling events regulated by Ret tyrosine kinase	42.0	3507.0	82.0	-0.11	0.055	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	38.0	3006.0	78.0	-0.156	0.051	1000.0	-1000.0	-0.046	-1000.0
BMP receptor signaling	37.0	3050.0	81.0	-0.273	0.15	1000.0	-1000.0	-0.044	-1000.0
Nongenotropic Androgen signaling	37.0	1924.0	52.0	-0.113	0.077	1000.0	-1000.0	-0.04	-1000.0
PLK1 signaling events	35.0	2998.0	85.0	-0.028	0.158	1000.0	-1000.0	-0.023	-1000.0
Integrins in angiogenesis	34.0	2878.0	84.0	-0.335	0.13	1000.0	-1000.0	-0.054	-1000.0
Calcium signaling in the CD4+ TCR pathway	34.0	1067.0	31.0	-0.172	0.024	1000.0	-1000.0	-0.057	-1000.0
Arf6 signaling events	32.0	1995.0	62.0	-0.138	0.043	1000.0	-1000.0	-0.029	-1000.0
IL6-mediated signaling events	30.0	2278.0	75.0	-0.466	0.05	1000.0	-1000.0	-0.048	-1000.0
Reelin signaling pathway	29.0	1651.0	56.0	-0.071	0.059	1000.0	-1000.0	-0.041	-1000.0
Canonical Wnt signaling pathway	29.0	1520.0	51.0	-0.34	0.157	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	28.0	3593.0	125.0	-0.131	0.051	1000.0	-1000.0	-0.053	-1000.0
Glypican 2 network	27.0	110.0	4.0	0.028	0.059	1000.0	-1000.0	0.011	-1000.0
Presenilin action in Notch and Wnt signaling	26.0	1635.0	61.0	-0.34	0.157	1000.0	-1000.0	-0.044	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	26.0	1769.0	68.0	-0.184	0.04	1000.0	-1000.0	-0.092	-1000.0
IL23-mediated signaling events	26.0	1602.0	60.0	-0.195	0.023	1000.0	-1000.0	-0.099	-1000.0
Coregulation of Androgen receptor activity	25.0	1916.0	76.0	-0.328	0.097	1000.0	-1000.0	-0.032	-1000.0
FOXA2 and FOXA3 transcription factor networks	25.0	1181.0	46.0	-0.7	0.106	1000.0	-1000.0	-0.105	-1000.0
Syndecan-3-mediated signaling events	25.0	889.0	35.0	-0.246	0.055	1000.0	-1000.0	-0.022	-1000.0
Visual signal transduction: Cones	24.0	931.0	38.0	-0.041	0.128	1000.0	-1000.0	-0.026	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	24.0	2111.0	85.0	-0.105	0.031	1000.0	-1000.0	-0.047	-1000.0
FOXM1 transcription factor network	24.0	1229.0	51.0	0.022	0.358	1000.0	-1000.0	-0.131	-1000.0
LPA4-mediated signaling events	23.0	284.0	12.0	-0.101	0.0	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	23.0	774.0	33.0	-0.166	0.097	1000.0	-1000.0	-0.032	-1000.0
HIF-1-alpha transcription factor network	22.0	1699.0	76.0	-0.108	0.141	1000.0	-1000.0	-0.094	-1000.0
Glucocorticoid receptor regulatory network	22.0	2528.0	114.0	-0.327	0.078	1000.0	-1000.0	-0.056	-1000.0
TCR signaling in naïve CD8+ T cells	22.0	2105.0	93.0	-0.062	0.032	1000.0	-1000.0	-0.058	-1000.0
Regulation of Androgen receptor activity	22.0	1582.0	70.0	-0.36	0.146	1000.0	-1000.0	-0.05	-1000.0
IL12-mediated signaling events	21.0	1871.0	87.0	-0.177	0.043	1000.0	-1000.0	-0.074	-1000.0
Syndecan-1-mediated signaling events	21.0	737.0	34.0	-0.093	0.154	1000.0	-1000.0	-0.046	-1000.0
Plasma membrane estrogen receptor signaling	21.0	1871.0	86.0	-0.11	0.038	1000.0	-1000.0	-0.056	-1000.0
ErbB4 signaling events	20.0	1422.0	69.0	-0.128	0.164	1000.0	-1000.0	-0.047	-1000.0
Nectin adhesion pathway	20.0	1295.0	63.0	-0.033	0.125	1000.0	-1000.0	-0.05	-1000.0
Wnt signaling	20.0	145.0	7.0	0.006	0.057	1000.0	-1000.0	-0.009	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	19.0	1039.0	54.0	-0.071	0.073	1000.0	-1000.0	-0.043	-1000.0
Glypican 1 network	19.0	927.0	48.0	-0.138	0.087	1000.0	-1000.0	-0.034	-1000.0
S1P1 pathway	19.0	700.0	36.0	-0.104	0.022	1000.0	-1000.0	-0.047	-1000.0
FAS signaling pathway (CD95)	18.0	853.0	47.0	-0.2	0.063	1000.0	-1000.0	-0.034	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	18.0	2168.0	120.0	-0.143	0.061	1000.0	-1000.0	-0.043	-1000.0
Caspase cascade in apoptosis	16.0	1228.0	74.0	-0.069	0.085	1000.0	-1000.0	-0.047	-1000.0
JNK signaling in the CD4+ TCR pathway	16.0	281.0	17.0	-0.035	0.031	1000.0	-1000.0	-0.037	-1000.0
Noncanonical Wnt signaling pathway	16.0	418.0	26.0	-0.054	0.057	1000.0	-1000.0	-0.039	-1000.0
TCGA08_p53	16.0	116.0	7.0	-0.029	0.022	1000.0	-1000.0	-0.014	-1000.0
Visual signal transduction: Rods	16.0	845.0	52.0	-0.041	0.094	1000.0	-1000.0	-0.036	-1000.0
p75(NTR)-mediated signaling	14.0	1857.0	125.0	-0.048	0.15	1000.0	-1000.0	-0.069	-1000.0
PDGFR-alpha signaling pathway	14.0	620.0	44.0	-0.131	0.046	1000.0	-1000.0	-0.038	-1000.0
Ephrin B reverse signaling	14.0	681.0	48.0	-0.058	0.063	1000.0	-1000.0	-0.03	-1000.0
IGF1 pathway	14.0	850.0	57.0	-0.056	0.059	1000.0	-1000.0	-0.049	-1000.0
Ras signaling in the CD4+ TCR pathway	14.0	239.0	17.0	-0.017	0.031	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PTP1B	13.0	1046.0	76.0	-0.048	0.057	1000.0	-1000.0	-0.034	-1000.0
S1P4 pathway	13.0	326.0	25.0	-0.028	0.032	1000.0	-1000.0	-0.03	-1000.0
Osteopontin-mediated events	12.0	469.0	38.0	-0.046	0.132	1000.0	-1000.0	-0.05	-1000.0
Aurora A signaling	12.0	721.0	60.0	-0.039	0.208	1000.0	-1000.0	-0.024	-1000.0
Effects of Botulinum toxin	12.0	333.0	26.0	-0.036	0.031	1000.0	-1000.0	-0.016	-1000.0
BCR signaling pathway	12.0	1189.0	99.0	-0.088	0.053	1000.0	-1000.0	-0.066	-1000.0
EGFR-dependent Endothelin signaling events	12.0	263.0	21.0	-0.025	0.049	1000.0	-1000.0	-0.041	-1000.0
HIF-2-alpha transcription factor network	11.0	474.0	43.0	-0.075	0.078	1000.0	-1000.0	-0.056	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	852.0	74.0	-0.137	0.049	1000.0	-1000.0	-0.067	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	306.0	28.0	-0.11	0.043	1000.0	-1000.0	-0.027	-1000.0
Hedgehog signaling events mediated by Gli proteins	10.0	702.0	65.0	-0.528	0.055	1000.0	-1000.0	-0.055	-1000.0
mTOR signaling pathway	10.0	537.0	53.0	-0.018	0.089	1000.0	-1000.0	-0.038	-1000.0
Syndecan-4-mediated signaling events	10.0	693.0	67.0	-0.032	0.087	1000.0	-1000.0	-0.047	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1356.0	136.0	-0.206	0.146	1000.0	-1000.0	-0.05	-1000.0
Syndecan-2-mediated signaling events	9.0	645.0	69.0	-0.032	0.087	1000.0	-1000.0	-0.04	-1000.0
Retinoic acid receptors-mediated signaling	9.0	543.0	58.0	-0.156	0.045	1000.0	-1000.0	-0.035	-1000.0
LPA receptor mediated events	9.0	957.0	102.0	-0.061	0.041	1000.0	-1000.0	-0.062	-1000.0
ErbB2/ErbB3 signaling events	8.0	538.0	65.0	-0.039	0.033	1000.0	-1000.0	-0.049	-1000.0
Cellular roles of Anthrax toxin	8.0	348.0	39.0	-0.062	0.022	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	8.0	487.0	58.0	-0.018	0.119	1000.0	-1000.0	-0.04	-1000.0
Regulation of p38-alpha and p38-beta	8.0	442.0	54.0	-0.044	0.053	1000.0	-1000.0	-0.047	-1000.0
IL27-mediated signaling events	8.0	448.0	51.0	-0.069	0.029	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by STAT5	8.0	176.0	22.0	0.006	0.077	1000.0	-1000.0	-0.037	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	326.0	45.0	-0.02	0.051	1000.0	-1000.0	-0.05	-1000.0
EPHB forward signaling	7.0	673.0	85.0	-0.042	0.085	1000.0	-1000.0	-0.067	-1000.0
Insulin Pathway	7.0	533.0	74.0	-0.09	0.061	1000.0	-1000.0	-0.062	-1000.0
PDGFR-beta signaling pathway	7.0	708.0	97.0	-0.047	0.065	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling in keratinocytes	7.0	332.0	43.0	-0.05	0.064	1000.0	-1000.0	-0.036	-1000.0
IFN-gamma pathway	6.0	475.0	68.0	-0.026	0.067	1000.0	-1000.0	-0.058	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	553.0	83.0	-0.069	0.041	1000.0	-1000.0	-0.035	-1000.0
TCGA08_rtk_signaling	6.0	181.0	26.0	-0.062	0.08	1000.0	-1000.0	-0.008	-1000.0
Class I PI3K signaling events	6.0	468.0	73.0	-0.031	0.042	1000.0	-1000.0	-0.045	-1000.0
S1P3 pathway	6.0	260.0	42.0	-0.11	0.042	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by PRL	6.0	218.0	34.0	-0.036	0.063	1000.0	-1000.0	-0.05	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	173.0	34.0	-0.032	0.051	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	5.0	281.0	55.0	-0.001	0.06	1000.0	-1000.0	-0.045	-1000.0
Ceramide signaling pathway	5.0	417.0	76.0	-0.011	0.06	1000.0	-1000.0	-0.04	-1000.0
TRAIL signaling pathway	5.0	252.0	48.0	-0.036	0.06	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class II	4.0	302.0	75.0	-0.036	0.056	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	4.0	234.0	57.0	-0.042	0.088	1000.0	-1000.0	-0.043	-1000.0
Ephrin A  reverse signaling	4.0	34.0	7.0	0.0	0.03	1000.0	-1000.0	-0.007	-1000.0
Signaling events mediated by HDAC Class III	4.0	190.0	40.0	-0.078	0.041	1000.0	-1000.0	-0.031	-1000.0
IL1-mediated signaling events	4.0	286.0	62.0	-0.021	0.042	1000.0	-1000.0	-0.043	-1000.0
ceramide signaling pathway	4.0	226.0	49.0	-0.0	0.033	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class I	4.0	514.0	104.0	-0.043	0.055	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	310.0	76.0	-0.014	0.06	1000.0	-1000.0	-0.057	-1000.0
VEGFR1 specific signals	4.0	256.0	56.0	-0.131	0.057	1000.0	-1000.0	-0.053	-1000.0
Arf6 downstream pathway	3.0	136.0	43.0	-0.044	0.045	1000.0	-1000.0	-0.027	-1000.0
Insulin-mediated glucose transport	3.0	107.0	32.0	-0.009	0.043	1000.0	-1000.0	-0.032	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	212.0	68.0	-0.034	0.047	1000.0	-1000.0	-0.037	-1000.0
FoxO family signaling	3.0	254.0	64.0	-0.023	0.072	1000.0	-1000.0	-0.073	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	115.0	36.0	-0.041	0.042	1000.0	-1000.0	-0.028	-1000.0
Arf6 trafficking events	3.0	250.0	71.0	-0.052	0.04	1000.0	-1000.0	-0.031	-1000.0
Regulation of Telomerase	3.0	365.0	102.0	-0.042	0.068	1000.0	-1000.0	-0.046	-1000.0
p38 MAPK signaling pathway	3.0	146.0	44.0	-0.003	0.054	1000.0	-1000.0	-0.029	-1000.0
Canonical NF-kappaB pathway	2.0	108.0	39.0	-0.006	0.046	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	14.0	5.0	0.018	0.029	1000.0	-1000.0	0.008	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	89.0	37.0	-0.013	0.052	1000.0	-1000.0	-0.034	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	34.0	15.0	-0.011	0.022	1000.0	-1000.0	-0.036	-1000.0
Circadian rhythm pathway	1.0	29.0	22.0	-0.006	0.048	1000.0	-1000.0	-0.032	-1000.0
S1P5 pathway	1.0	23.0	17.0	-0.015	0.03	1000.0	-1000.0	-0.018	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	52.0	27.0	-0.009	0.053	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	1.0	31.0	20.0	-0.011	0.024	1000.0	-1000.0	-0.013	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.021	0.021	1000.0	-1000.0	-0.01	-1000.0
Arf1 pathway	1.0	76.0	54.0	-0.005	0.031	1000.0	-1000.0	-0.017	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	0.003	0.043	1000.0	-1000.0	-0.027	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	-0.009	0.022	1000.0	-1000.0	-0.03	-1000.0
Atypical NF-kappaB pathway	0.0	11.0	31.0	-0.008	0.023	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.021	0.041	1000.0	-1000.0	0.009	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	0.0	0.06	1000.0	-1000.0	0.0	-1000.0
Total	2435	157382	7203	-14.3645377294	9.62675606522	131000	-131000	-5.45321032792	-131000