E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.025 0.135 -9999.0 0.0 -0.401 13.0 13.0 KLHL20 -0.008 0.109 0.258 1.0 -0.3 10.0 11.0 CYFIP2 0.025 0.046 -9999.0 0.0 -0.506 1.0 1.0 Rac1/GDP -0.001 0.102 0.249 1.0 -0.275 7.0 8.0 ENAH -0.025 0.139 -9999.0 0.0 -0.4 15.0 15.0 AP1M1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.061 -9999.0 0.0 -0.506 2.0 2.0 CTNNB1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.074 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.032 0.059 -9999.0 0.0 -0.197 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.053 0.082 -9999.0 0.0 -0.285 7.0 7.0 RAPGEF1 -0.015 0.121 -9999.0 0.0 -0.381 10.0 10.0 CTNND1 0.015 0.096 -9999.0 0.0 -0.506 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.147 -9999.0 0.0 -0.41 15.0 15.0 CRK -0.015 0.127 -9999.0 0.0 -0.387 13.0 13.0 E-cadherin/gamma catenin/alpha catenin 0.017 0.123 -9999.0 0.0 -0.331 16.0 16.0 alphaE/beta7 Integrin 0.045 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.047 -9999.0 0.0 -0.506 1.0 1.0 Rap1/GTP/I-afadin 0.052 0.043 -9999.0 0.0 -0.285 2.0 2.0 DLG1 -0.019 0.11 -9999.0 0.0 -0.377 9.0 9.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.043 -9999.0 0.0 -0.251 2.0 2.0 MLLT4 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.054 0.044 -9999.0 0.0 -0.285 2.0 2.0 PI3K -0.01 0.057 -9999.0 0.0 -0.33 2.0 2.0 ARF6 0.024 0.062 -9999.0 0.0 -0.506 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.002 0.135 -9999.0 0.0 -0.387 16.0 16.0 TIAM1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.039 0.095 -9999.0 0.0 -0.269 12.0 12.0 AKT1 0.005 0.055 0.156 1.0 -0.21 4.0 5.0 PIK3R1 0.005 0.098 -9999.0 0.0 -0.506 5.0 5.0 CDH1 0.006 0.113 -9999.0 0.0 -0.506 7.0 7.0 RhoA/GDP 0.004 0.1 0.251 1.0 -0.275 6.0 7.0 actin cytoskeleton organization -0.003 0.081 0.179 2.0 -0.212 10.0 12.0 CDC42/GDP 0.002 0.103 0.251 1.0 -0.275 7.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.102 -9999.0 0.0 -0.266 20.0 20.0 ITGB7 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.042 0.101 -9999.0 0.0 -0.286 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.07 -9999.0 0.0 -0.266 7.0 7.0 mol:GDP -0.015 0.108 0.252 1.0 -0.315 7.0 8.0 CDC42/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.004 0.133 -9999.0 0.0 -0.506 10.0 10.0 p120 catenin/RhoA/GDP 0.006 0.109 0.257 1.0 -0.278 9.0 10.0 RAC1/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.037 -9999.0 0.0 -0.368 1.0 1.0 RHOA 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.008 0.076 0.166 1.0 -0.219 13.0 14.0 NME1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.027 0.14 -9999.0 0.0 -0.4 15.0 15.0 regulation of cell-cell adhesion 0.0 0.06 -9999.0 0.0 -0.197 1.0 1.0 WASF2 -0.004 0.045 -9999.0 0.0 -0.139 6.0 6.0 Rap1/GTP 0.009 0.081 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.12 -9999.0 0.0 -0.287 16.0 16.0 CCND1 -0.011 0.094 0.189 1.0 -0.275 13.0 14.0 VAV2 -0.045 0.229 -9999.0 0.0 -0.634 15.0 15.0 RAP1/GDP 0.012 0.091 0.266 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.026 0.136 -9999.0 0.0 -0.388 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.045 -9999.0 0.0 -0.506 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.024 0.109 -9999.0 0.0 -0.278 15.0 15.0 E-cadherin/beta catenin -0.004 0.08 -9999.0 0.0 -0.338 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.027 0.139 -9999.0 0.0 -0.4 15.0 15.0 PIK3CA 0.01 0.061 -9999.0 0.0 -0.506 2.0 2.0 Rac1/GTP -0.063 0.157 -9999.0 0.0 -0.486 13.0 13.0 E-cadherin/beta catenin/alpha catenin 0.039 0.082 -9999.0 0.0 -0.312 7.0 7.0 ITGAE 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.149 -9999.0 0.0 -0.418 15.0 15.0