Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.135 0.275 -9999.0 0.0 -0.564 42.0 42.0 IHH -0.014 0.089 -9999.0 0.0 -0.533 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.043 0.142 -9999.0 0.0 -0.32 29.0 29.0 LRPAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.043 0.141 0.318 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.114 0.234 -9999.0 0.0 -0.581 20.0 20.0 SMO -0.129 0.238 -9999.0 0.0 -0.597 21.0 21.0 AKT1 -0.089 0.211 -9999.0 0.0 -0.696 13.0 13.0 ARRB2 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.127 0.234 -9999.0 0.0 -0.586 21.0 21.0 STIL -0.076 0.156 -9999.0 0.0 -0.455 11.0 11.0 DHH N/PTCH2 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.049 0.162 -9999.0 0.0 -0.35 15.0 15.0 PIK3CA 0.01 0.061 -9999.0 0.0 -0.506 2.0 2.0 DHH 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.249 0.449 -9999.0 0.0 -0.955 43.0 43.0 determination of left/right symmetry -0.127 0.234 -9999.0 0.0 -0.586 21.0 21.0 PIK3R1 0.005 0.098 -9999.0 0.0 -0.506 5.0 5.0 skeletal system development -0.245 0.442 -9999.0 0.0 -0.942 43.0 43.0 IHH N/Hhip -0.054 0.156 -9999.0 0.0 -0.419 21.0 21.0 DHH N/Hhip -0.023 0.135 -9999.0 0.0 -0.368 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.127 0.234 -9999.0 0.0 -0.586 21.0 21.0 pancreas development -0.057 0.178 -9999.0 0.0 -0.506 20.0 20.0 HHAT -0.006 0.139 -9999.0 0.0 -0.506 11.0 11.0 PI3K 0.005 0.075 -9999.0 0.0 -0.368 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.052 0.183 -9999.0 0.0 -0.506 21.0 21.0 somite specification -0.127 0.234 -9999.0 0.0 -0.586 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.068 0.163 -9999.0 0.0 -0.453 11.0 11.0 SHH Np/Cholesterol/PTCH2 0.008 0.085 -9999.0 0.0 -0.284 12.0 12.0 SHH Np/Cholesterol/Megalin 0.002 0.091 -9999.0 0.0 -0.291 13.0 13.0 SHH -0.013 0.103 -9999.0 0.0 -0.368 12.0 12.0 catabolic process -0.069 0.172 -9999.0 0.0 -0.337 42.0 42.0 SMO/Vitamin D3 -0.102 0.203 -9999.0 0.0 -0.526 18.0 18.0 SHH Np/Cholesterol/Hhip -0.043 0.126 -9999.0 0.0 -0.294 29.0 29.0 LRP2 0.02 0.052 -9999.0 0.0 -0.506 1.0 1.0 receptor-mediated endocytosis -0.101 0.194 -9999.0 0.0 -0.504 18.0 18.0 SHH Np/Cholesterol/BOC -0.0 0.085 -9999.0 0.0 -0.284 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.086 -9999.0 0.0 -0.287 12.0 12.0 mesenchymal cell differentiation 0.043 0.125 0.293 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.069 0.162 -9999.0 0.0 -0.453 11.0 11.0 IHH N/PTCH2 0.015 0.06 -9999.0 0.0 -0.322 1.0 1.0 CDON 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.062 0.179 -9999.0 0.0 -0.339 42.0 42.0 Megalin/LRPAP1 0.034 0.043 -9999.0 0.0 -0.368 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.081 -9999.0 0.0 -0.283 12.0 12.0 PTCH1 -0.069 0.173 -9999.0 0.0 -0.338 42.0 42.0 HHIP -0.057 0.178 -9999.0 0.0 -0.506 20.0 20.0